Details for: PPP1R15A
Associated with
Other Information
Genular Protein ID: 333741979
Symbol: PR15A_HUMAN
Name: Protein phosphatase 1 regulatory subunit 15A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9153226
Title: Mammalian GADD34, an apoptosis- and DNA damage-inducible gene.
PubMed ID: 9153226
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8139541
Title: The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.
PubMed ID: 8139541
PubMed ID: 10490642
Title: Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins.
PubMed ID: 10490642
PubMed ID: 11517336
Title: Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis.
PubMed ID: 11517336
PubMed ID: 11564868
Title: Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.
PubMed ID: 11564868
PubMed ID: 12016208
Title: The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.
PubMed ID: 12016208
PubMed ID: 12114539
Title: mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.
PubMed ID: 12114539
PubMed ID: 14635196
Title: GADD34 induces p53 phosphorylation and p21/WAF1 transcription.
PubMed ID: 14635196
DOI: 10.1002/jcb.10711
PubMed ID: 12556489
Title: Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
PubMed ID: 12556489
PubMed ID: 12724406
Title: Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions.
PubMed ID: 12724406
PubMed ID: 14718519
Title: GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor.
PubMed ID: 14718519
PubMed ID: 15705855
Title: A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
PubMed ID: 15705855
PubMed ID: 19131336
Title: An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.
PubMed ID: 19131336
PubMed ID: 21518769
Title: Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.
PubMed ID: 21518769
PubMed ID: 24092754
Title: Phosphorylation at tyrosine 262 promotes GADD34 protein turnover.
PubMed ID: 24092754
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 26742780
Title: Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2alpha-mediated stress signaling.
PubMed ID: 26742780
PubMed ID: 31778897
Title: GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition.
PubMed ID: 31778897
PubMed ID: 32978159
Title: GADD34 is a modulator of autophagy during starvation.
PubMed ID: 32978159
PubMed ID: 34985336
Title: Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.
PubMed ID: 34985336
PubMed ID: 26095357
Title: Structural and Functional Analysis of the GADD34:PP1 eIF2alpha Phosphatase.
PubMed ID: 26095357
Sequence Information:
- Length: 674
- Mass: 73478
- Checksum: B257AA17456D1403
- Sequence:
MAPGQAPHQA TPWRDAHPFF LLSPVMGLLS RAWSRLRGLG PLEPWLVEAV KGAALVEAGL EGEARTPLAI PHTPWGRRPE EEAEDSGGPG EDRETLGLKT SSSLPEAWGL LDDDDGMYGE REATSVPRGQ GSQFADGQRA PLSPSLLIRT LQGSDKNPGE EKAEEEGVAE EEGVNKFSYP PSHRECCPAV EEEDDEEAVK KEAHRTSTSA LSPGSKPSTW VSCPGEEENQ ATEDKRTERS KGARKTSVSP RSSGSDPRSW EYRSGEASEE KEEKAHKETG KGEAAPGPQS SAPAQRPQLK SWWCQPSDEE EGEVKALGAA EKDGEAECPP CIPPPSAFLK AWVYWPGEDT EEEEDEEEDE DSDSGSDEEE GEAEASSSTP ATGVFLKSWV YQPGEDTEEE EDEDSDTGSA EDEREAETSA STPPASAFLK AWVYRPGEDT EEEEDEDVDS EDKEDDSEAA LGEAESDPHP SHPDQRAHFR GWGYRPGKET EEEEAAEDWG EAEPCPFRVA IYVPGEKPPP PWAPPRLPLR LQRRLKRPET PTHDPDPETP LKARKVRFSE KVTVHFLAVW AGPAQAARQG PWEQLARDRS RFARRITQAQ EELSPCLTPA ARARAWARLR NPPLAPIPAL TQTLPSSSVP SSPVQTTPLS QAVATPSRSS AAAAAALDLS GRRG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.