SLC7A11 | ENSG00000151012 | NCBI 23657

Details for: SLC7A11

Gene ID: 23657

Symbol: SLC7A11

Ensembl ID: ENSG00000151012

Description: solute carrier family 7 member 11

Associated with

Amino acid transport across the plasma membrane
(R-HSA-352230)
Basigin interactions
(R-HSA-210991)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Hemostasis
(R-HSA-109582)
Keap1-nfe2l2 pathway
(R-HSA-9755511)
Nfe2l2 regulating anti-oxidant/detoxification enzymes
(R-HSA-9818027)
Nuclear events mediated by nfe2l2
(R-HSA-9759194)
Slc-mediated transmembrane transport
(R-HSA-425407)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-HSA-425393)
Transport of small molecules
(R-HSA-382551)
Adult behavior
(GO:0030534)
Amino acid transmembrane transport
(GO:0003333)
Apical part of cell
(GO:0045177)
Astrocyte projection
(GO:0097449)
Brush border membrane
(GO:0031526)
Cell surface
(GO:0009986)
Cellular response to oxidative stress
(GO:0034599)
Cystine:glutamate antiporter activity
(GO:0015327)
Dipeptide import across plasma membrane
(GO:0140206)
Glutathione metabolic process
(GO:0006749)
Glutathione transmembrane transport
(GO:0034775)
Intracellular glutamate homeostasis
(GO:0090461)
L-amino acid transmembrane transporter activity
(GO:0015179)
L-cystine transport
(GO:0015811)
L-glutamate import across plasma membrane
(GO:0098712)
L-glutamate transmembrane transport
(GO:0015813)
L-kynurenine transmembrane transport
(GO:0140924)
L-kynurenine transmembrane transporter activity
(GO:0140926)
Lens fiber cell differentiation
(GO:0070306)
Limb development
(GO:0060173)
Lung alveolus development
(GO:0048286)
Membrane
(GO:0016020)
Microvillus membrane
(GO:0031528)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of ferroptosis
(GO:0110076)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Protein binding
(GO:0005515)
Regulation of ampa glutamate receptor clustering
(GO:1904717)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of cysteine metabolic process
(GO:1901494)
Regulation of glutamate metabolic process
(GO:2000211)
Regulation of glutathione biosynthetic process
(GO:1903786)
Regulation of melanin biosynthetic process
(GO:0048021)
Regulation of neutrophil apoptotic process
(GO:0033029)
Regulation of protein transport
(GO:0051223)
Regulation of synapse organization
(GO:0050807)
Response to nicotine
(GO:0035094)
Response to organic cyclic compound
(GO:0014070)
Response to redox state
(GO:0051775)
Response to toxic substance
(GO:0009636)
Striatum development
(GO:0021756)
Ventricular system development
(GO:0021591)
Visual learning
(GO:0008542)

Other Information

Proteins

Amino acid transport system xc-

Genular Protein ID: 2166882840

Symbol: XCT_HUMAN

Name: Amino acid transport system xc-

UniProtKB Accession Codes:

Q9UPY5 A8K2U4

Database IDs:

Citations:

PubMed ID: 11213471

Title: Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-.

PubMed ID: 11213471

DOI: 10.1089/ars.2000.2.4-665

PubMed ID: 11417227

Title: Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-.

PubMed ID: 11417227

DOI: 10.1007/s004240100537

PubMed ID: 11133847

Title: Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.

PubMed ID: 11133847

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14722095

Title: Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway.

PubMed ID: 14722095

DOI: 10.1074/jbc.m309866200

PubMed ID: 15151999

Title: Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.

PubMed ID: 15151999

DOI: 10.1074/jbc.m402428200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 34120018

Title: N-acetylcysteine, xCT and suppression of Maxi-chloride channel activity in human placenta.

PubMed ID: 34120018

DOI: 10.1016/j.placenta.2021.05.009

PubMed ID: 35245456

Title: Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling.

PubMed ID: 35245456

DOI: 10.1016/j.molcel.2022.02.007

PubMed ID: 34880232

Title: Molecular basis for redox control by the human cystine/glutamate antiporter system xc.

PubMed ID: 34880232

DOI: 10.1038/s41467-021-27414-1

PubMed ID: 35352032

Title: The structure of erastin-bound xCT-4F2hc complexreveals molecular mechanisms underlying erastin-induced ferroptosis.

PubMed ID: 35352032

DOI: 10.1038/s41422-022-00642-w

Sequence Information:

Length: 501
Mass: 55423
Checksum: 3EF2648B94A9F59E
Sequence:

MVRKPVVSTI SKGGYLQGNV NGRLPSLGNK EPPGQEKVQL KRKVTLLRGV SIIIGTIIGA 
GIFISPKGVL QNTGSVGMSL TIWTVCGVLS LFGALSYAEL GTTIKKSGGH YTYILEVFGP 
LPAFVRVWVE LLIIRPAATA VISLAFGRYI LEPFFIQCEI PELAIKLITA VGITVVMVLN 
SMSVSWSARI QIFLTFCKLT AILIIIVPGV MQLIKGQTQN FKDAFSGRDS SITRLPLAFY 
YGMYAYAGWF YLNFVTEEVE NPEKTIPLAI CISMAIVTIG YVLTNVAYFT TINAEELLLS 
NAVAVTFSER LLGNFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 
RKHTPLPAVI VLHPLTMIML FSGDLDSLLN FLSFARWLFI GLAVAGLIYL RYKCPDMHRP 
FKVPLFIPAL FSFTCLFMVA LSLYSDPFST GIGFVITLTG VPAYYLFIIW DKKPRWFRIM 
SEKITRTLQI ILEVVPEEDK L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SLC7A11

Associated with

Other Information

Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-. PubMed ID: 11213471

Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-. PubMed ID: 11417227

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells. PubMed ID: 11133847

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway. PubMed ID: 14722095

Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility. PubMed ID: 15151999

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-acetylcysteine, xCT and suppression of Maxi-chloride channel activity in human placenta. PubMed ID: 34120018

Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling. PubMed ID: 35245456

Molecular basis for redox control by the human cystine/glutamate antiporter system xc. PubMed ID: 34880232

The structure of erastin-bound xCT-4F2hc complexreveals molecular mechanisms underlying erastin-induced ferroptosis. PubMed ID: 35352032