PLA2G15 | ENSG00000103066 | NCBI 23659

Details for: PLA2G15

Gene ID: 23659

Symbol: PLA2G15

Ensembl ID: ENSG00000103066

Description: phospholipase A2 group XV

Associated with

Glycerophospholipid biosynthesis
(R-HSA-1483206)
Hydrolysis of lpc
(R-HSA-1483115)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Phospholipid metabolism
(R-HSA-1483257)
1-acyl-2-lysophosphatidylserine acylhydrolase activity
(GO:0052740)
Acylglycerol o-acyltransferase activity
(GO:0016411)
Calcium-independent phospholipase a2 activity
(GO:0047499)
Ceramide metabolic process
(GO:0006672)
Diacylglycerol biosynthetic process
(GO:0006651)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fatty acid catabolic process
(GO:0009062)
Glycerophospholipid metabolic process
(GO:0006650)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysophospholipase activity
(GO:0004622)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Nucleoplasm
(GO:0005654)
O-acyltransferase activity
(GO:0008374)
Phosphatidylcholine catabolic process
(GO:0034638)
Phosphatidylcholine metabolic process
(GO:0046470)
Phosphatidylethanolamine catabolic process
(GO:0046338)
Phosphatidylglycerol metabolic process
(GO:0046471)
Phosphatidyl phospholipase b activity
(GO:0102545)
Phosphatidylserine 1-acylhydrolase activity
(GO:0052739)
Phosphatidylserine metabolic process
(GO:0006658)
Phospholipase a1 activity
(GO:0008970)
Phospholipid binding
(GO:0005543)
Phospholipid metabolic process
(GO:0006644)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Phospholipase A2 group XV

Genular Protein ID: 3900711290

Symbol: PAG15_HUMAN

Name: Phospholipase A2 group XV

UniProtKB Accession Codes:

Q8NCC3 B3KMF3 B4DUD1 Q53GZ1 Q9NPQ6 Q9UG04 Q9Y2B3

Database IDs:

Citations:

PubMed ID: 10092508

Title: Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.

PubMed ID: 10092508

DOI: 10.1006/bbrc.1999.0411

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 11790796

Title: Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase.

PubMed ID: 11790796

DOI: 10.1074/jbc.m111977200

PubMed ID: 20410020

Title: The measurement of lysosomal phospholipase A2 activity in plasma.

PubMed ID: 20410020

DOI: 10.1194/jlr.d007146

PubMed ID: 23958596

Title: Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme.

PubMed ID: 23958596

DOI: 10.1194/jlr.m041640

PubMed ID: 29724779

Title: Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2.

PubMed ID: 29724779

DOI: 10.1194/jlr.m084012

PubMed ID: 25727495

Title: Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase.

PubMed ID: 25727495

DOI: 10.1038/ncomms7250

PubMed ID: 30830753

Title: Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2.

PubMed ID: 30830753

DOI: 10.1021/acs.biochem.8b01124

Sequence Information:

Length: 412
Mass: 46658
Checksum: 1FEA8A5783AF050A
Sequence:

MGLHLRPYRV GLLPDGLLFL LLLLMLLADP ALPAGRHPPV VLVPGDLGNQ LEAKLDKPTV 
VHYLCSKKTE SYFTIWLNLE LLLPVIIDCW IDNIRLVYNK TSRATQFPDG VDVRVPGFGK 
TFSLEFLDPS KSSVGSYFHT MVESLVGWGY TRGEDVRGAP YDWRRAPNEN GPYFLALREM 
IEEMYQLYGG PVVLVAHSMG NMYTLYFLQR QPQAWKDKYI RAFVSLGAPW GGVAKTLRVL 
ASGDNNRIPV IGPLKIREQQ RSAVSTSWLL PYNYTWSPEK VFVQTPTINY TLRDYRKFFQ 
DIGFEDGWLM RQDTEGLVEA TMPPGVQLHC LYGTGVPTPD SFYYESFPDR DPKICFGDGD 
GTVNLKSALQ CQAWQSRQEH QVLLQELPGS EHIEMLANAT TLAYLKRVLL GP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PLA2G15

Associated with

Other Information

Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase. PubMed ID: 10092508

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Cloning and characterization of a lysosomal phospholipase A2, 1-O-acylceramide synthase. PubMed ID: 11790796

The measurement of lysosomal phospholipase A2 activity in plasma. PubMed ID: 20410020

Role of N-glycosylation of human lysosomal phospholipase A2 for the formation of catalytically active enzyme. PubMed ID: 23958596

Determinants of pH profile and acyl chain selectivity in lysosomal phospholipase A2. PubMed ID: 29724779

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase. PubMed ID: 25727495

Structural Basis of Lysosomal Phospholipase A2 Inhibition by Zn2. PubMed ID: 30830753