Details for: TMEFF2

Gene ID: 23671

Symbol: TMEFF2

Ensembl ID: ENSG00000144339

Description: transmembrane protein with EGF like and two follistatin like domains 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 6.97
    Marker Score: 37,422
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 5.28
    Marker Score: 178,302
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.24
    Marker Score: 69,661
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 5.07
    Marker Score: 26,623
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 4.95
    Marker Score: 16,599
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 4.94
    Marker Score: 11,361
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.49
    Marker Score: 2,015
  • Cell Name: granule cell (CL0000120)
    Fold Change: 4.03
    Marker Score: 30,408
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.74
    Marker Score: 8,945
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.83
    Marker Score: 3,979
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.78
    Marker Score: 55,318
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.75
    Marker Score: 21,113
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.69
    Marker Score: 7,680
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.67
    Marker Score: 3,221
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.6
    Marker Score: 12,050
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.59
    Marker Score: 4,916
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.55
    Marker Score: 38,136
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.52
    Marker Score: 3,393
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.49
    Marker Score: 8,842
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.38
    Marker Score: 90,342
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.36
    Marker Score: 4,293
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.22
    Marker Score: 1,067
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.21
    Marker Score: 49,320
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.21
    Marker Score: 4,564
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2
    Marker Score: 8,508
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.18
    Marker Score: 1,504
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.15
    Marker Score: 20,208
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.06
    Marker Score: 8,520
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 125,834
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.99
    Marker Score: 1,986
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.97
    Marker Score: 20,310
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,308
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.9
    Marker Score: 70,015
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.87
    Marker Score: 629
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16,056
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.87
    Marker Score: 2,261
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.8
    Marker Score: 7,320
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.68
    Marker Score: 975
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.68
    Marker Score: 2,074
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.63
    Marker Score: 2,517
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,165
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.58
    Marker Score: 2,647
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.5
    Marker Score: 1,679
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.47
    Marker Score: 565
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165,854
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.43
    Marker Score: 800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.37
    Marker Score: 2,790
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.28
    Marker Score: 606
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,373
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 485
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.15
    Marker Score: 689
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,792
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.13
    Marker Score: 4,709
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.07
    Marker Score: 1,201
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.03
    Marker Score: 603
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.02
    Marker Score: 324
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,782
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,008
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.98
    Marker Score: 699
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.94
    Marker Score: 464
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,314
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.93
    Marker Score: 6,162
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.92
    Marker Score: 3,548
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.9
    Marker Score: 690
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9
    Marker Score: 5,413
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.8
    Marker Score: 537
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.8
    Marker Score: 503
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.8
    Marker Score: 3,323
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.78
    Marker Score: 417
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.78
    Marker Score: 199
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.75
    Marker Score: 437
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 235
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,193
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.73
    Marker Score: 702
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.71
    Marker Score: 246
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.7
    Marker Score: 418
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.69
    Marker Score: 331
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.68
    Marker Score: 778
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.65
    Marker Score: 1,870
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.64
    Marker Score: 796
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.58
    Marker Score: 346
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.57
    Marker Score: 628
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.56
    Marker Score: 271
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEFF2 is a transmembrane protein consisting of two follistatin-like domains and an EGF-like domain. Its unique structure allows it to interact with various ligands and receptors, influencing cellular behavior. The follistatin-like domains are known to bind to follistatin, a protein that regulates the activity of activin, a member of the TGF-β superfamily. This interaction can modulate cell growth, differentiation, and survival. The EGF-like domain, on the other hand, is involved in cell signaling, promoting cell migration, proliferation, and differentiation. **Pathways and Functions:** TMEFF2 is involved in several cellular pathways, including: 1. **Cell differentiation**: TMEFF2 regulates the differentiation of various cell types, including neurons, cardiac muscle cells, and macroglial cells. 2. **Negative regulation of cell migration**: TMEFF2 inhibits cell migration by interacting with integrins, which are essential for cell adhesion and migration. 3. **Negative regulation of integrin biosynthetic process**: TMEFF2 modulates the expression of integrins, which are crucial for cell migration and adhesion. 4. **Negative regulation of stress fiber assembly**: TMEFF2 regulates the assembly of stress fibers, which are essential for cell migration and contraction. 5. **Protein binding**: TMEFF2 interacts with various proteins, including follistatin, integrins, and growth factors, to regulate cellular behavior. **Clinical Significance:** TMEFF2 has been identified as a significant player in various diseases, including: 1. **Neurological disorders**: TMEFF2 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it regulates neuronal differentiation and survival. 2. **Cardiovascular diseases**: TMEFF2 has been linked to cardiovascular diseases, including atherosclerosis and cardiac hypertrophy, where it regulates cell migration and differentiation. 3. **Cancer**: TMEFF2 has been identified as a potential oncogene, where it regulates cell proliferation, migration, and invasion. In conclusion, TMEFF2 is a complex transmembrane protein that plays a significant role in regulating cellular behavior, including cell differentiation, migration, and survival. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the immunological significance of TMEFF2.

Genular Protein ID: 986016170

Symbol: TEFF2_HUMAN

Name: Tomoregulin-2

UniProtKB Accession Codes:

Q9UIK5 Q2FA44 Q4ZFW4 Q53H90 Q53RE1 Q8N2R5 Q9NR15 Q9NSS5 Q9P2Y9 Q9UK65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10903839

Title: Identification and characterization of TMEFF2, a novel survival factor for hippocampal and mesencephalic neurons.

PubMed ID: 10903839

DOI: 10.1006/geno.2000.6228

PubMed ID: 10987305

Title: The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells.

PubMed ID: 10987305

PubMed ID: 11668495

Title: TENB2, a proteoglycan identified in prostate cancer that is associated with disease progression and androgen independence.

PubMed ID: 11668495

DOI: 10.1002/ijc.1450

PubMed ID: 16439095

Title: A truncated isoform of TMEFF2 encodes a secreted protein in prostate cancer cells.

PubMed ID: 16439095

DOI: 10.1016/j.ygeno.2005.12.004

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10600548

Title: A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 in MKN28 gastric cancer cells.

PubMed ID: 10600548

DOI: 10.1006/bbrc.1999.1873

PubMed ID: 11120884

Title: HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers.

PubMed ID: 11120884

DOI: 10.1073/pnas.98.1.265

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16805794

Title: Tomoregulin-2 is found extensively in plaques in Alzheimer's disease brain.

PubMed ID: 16805794

DOI: 10.1111/j.1471-4159.2006.03801.x

PubMed ID: 17942404

Title: Phorbol ester-induced shedding of the prostate cancer marker transmembrane protein with epidermal growth factor and two follistatin motifs 2 is mediated by the disintegrin and metalloproteinase-17.

PubMed ID: 17942404

DOI: 10.1074/jbc.m702170200

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

Sequence Information:

  • Length: 374
  • Mass: 41428
  • Checksum: 44452F680FEBDCDB
  • Sequence:
    • MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD 
DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA 
CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC 
VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG 
HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC 
EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH 
YSSDNTTRAS TRLI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.