Details for: PRKD3

Gene ID: 23683

Symbol: PRKD3

Ensembl ID: ENSG00000115825

Description: protein kinase D3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.02
    Marker Score: 1,055
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.93
    Marker Score: 4,836
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.8
    Marker Score: 1,048
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.75
    Marker Score: 2,124
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.68
    Marker Score: 1,002
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.56
    Marker Score: 565
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.48
    Marker Score: 1,994
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.46
    Marker Score: 6,095
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.41
    Marker Score: 4,179
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.38
    Marker Score: 829
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.37
    Marker Score: 408
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.37
    Marker Score: 832
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.35
    Marker Score: 1,328
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.34
    Marker Score: 473
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.32
    Marker Score: 1,425
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.29
    Marker Score: 1,608
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.24
    Marker Score: 615
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.22
    Marker Score: 1,773
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.2
    Marker Score: 1,194
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.18
    Marker Score: 1,357
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.17
    Marker Score: 2,561
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.16
    Marker Score: 10,186
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.16
    Marker Score: 2,228
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.13
    Marker Score: 660
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.11
    Marker Score: 2,024
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1
    Marker Score: 322
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1
    Marker Score: 347
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.08
    Marker Score: 1,308
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.08
    Marker Score: 36,619
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.07
    Marker Score: 1,158
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.05
    Marker Score: 358
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.05
    Marker Score: 250
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.03
    Marker Score: 1,143
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.03
    Marker Score: 1,792
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.01
    Marker Score: 244
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,636
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47,860
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.99
    Marker Score: 2,832
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.98
    Marker Score: 343
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,383
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.98
    Marker Score: 475
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.98
    Marker Score: 548
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.97
    Marker Score: 641
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.97
    Marker Score: 393
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,386
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.93
    Marker Score: 890
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.93
    Marker Score: 706
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.93
    Marker Score: 980
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.93
    Marker Score: 996
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.93
    Marker Score: 519
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.92
    Marker Score: 16,392
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.91
    Marker Score: 219
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.91
    Marker Score: 447
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.9
    Marker Score: 810
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.9
    Marker Score: 486
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,682
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.89
    Marker Score: 346
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.89
    Marker Score: 1,772
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.88
    Marker Score: 370
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.87
    Marker Score: 201
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.87
    Marker Score: 752
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.87
    Marker Score: 199
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.85
    Marker Score: 193
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.85
    Marker Score: 203
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.84
    Marker Score: 239
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.84
    Marker Score: 583
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.84
    Marker Score: 17,836
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.84
    Marker Score: 746
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.82
    Marker Score: 9,256
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 328
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.81
    Marker Score: 4,648
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.81
    Marker Score: 349
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.8
    Marker Score: 200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8
    Marker Score: 910
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.8
    Marker Score: 710
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.8
    Marker Score: 1,033
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.8
    Marker Score: 173
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.79
    Marker Score: 12,744
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.79
    Marker Score: 452
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.79
    Marker Score: 323
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.79
    Marker Score: 1,970
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.79
    Marker Score: 209
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.78
    Marker Score: 193
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 595
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.78
    Marker Score: 181
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.78
    Marker Score: 2,761
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.77
    Marker Score: 197
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.77
    Marker Score: 670
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,252
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1,568
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.77
    Marker Score: 427
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.76
    Marker Score: 288
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.76
    Marker Score: 200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.76
    Marker Score: 1,173
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.76
    Marker Score: 167
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.76
    Marker Score: 429

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PRKD3 is a serine/threonine kinase enzyme that belongs to the protein kinase D family. It is primarily localized to the plasma membrane and cytosol, where it interacts with various signaling molecules to regulate cellular responses. The gene is highly expressed in multiple cell types, including rod bipolar cells, skeletal muscle fibers, and immune cells such as microglia and B cells. PRKD3's expression is also observed in certain cancer cells, suggesting its potential role in tumorigenesis. **Pathways and Functions:** PRKD3 is involved in multiple signaling pathways, including: 1. **Diacylglycerol-dependent serine/threonine kinase activity**: PRKD3 is activated by diacylglycerol, a second messenger molecule produced in response to various stimuli, including growth factors and hormones. 2. **Protein kinase C-activating G protein-coupled receptor signaling pathway**: PRKD3 interacts with protein kinase C (PKC) to regulate the activity of G protein-coupled receptors (GPCRs), which are involved in various cellular processes, including cell proliferation and differentiation. 3. **Sphingolipid biosynthetic process**: PRKD3 is involved in the regulation of sphingolipid metabolism, which is critical for cell signaling, membrane trafficking, and cell survival. 4. **Intracellular signal transduction**: PRKD3 plays a role in regulating various signaling pathways, including the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) pathways. **Functions:** PRKD3's functions can be summarized as follows: 1. **Cell signaling**: PRKD3 regulates various signaling pathways, including those involved in cell proliferation, differentiation, and survival. 2. **Lipid metabolism**: PRKD3 is involved in the regulation of sphingolipid metabolism, which is critical for cell signaling and membrane trafficking. 3. **Immune responses**: PRKD3 is expressed in immune cells, including microglia and B cells, and plays a role in regulating immune responses. 4. **Cell proliferation**: PRKD3 is involved in regulating cell proliferation, particularly in cancer cells. **Clinical Significance:** PRKD3's dysregulation has been implicated in various diseases, including: 1. **Cancer**: PRKD3's overexpression has been observed in certain cancer types, suggesting its potential role in tumorigenesis. 2. **Neurodegenerative diseases**: PRKD3's involvement in lipid metabolism and signaling pathways suggests its potential role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Immune disorders**: PRKD3's expression in immune cells and its involvement in immune responses suggest its potential role in immune disorders, such as multiple sclerosis and rheumatoid arthritis. In conclusion, PRKD3 is a multifunctional protein kinase that plays a critical role in various cellular processes, including signal transduction, metabolism, and cell survival. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the gene's functions and clinical significance.

Genular Protein ID: 400956723

Symbol: KPCD3_HUMAN

Name: Serine/threonine-protein kinase D3

UniProtKB Accession Codes:

O94806 D6W587 Q53TR7 Q8NEL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10231560

Title: PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu.

PubMed ID: 10231560

DOI: 10.1016/s0167-4889(99)00040-3

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18076381

Title: Selective binding of phorbol esters and diacylglycerol by individual C1 domains of the PKD family.

PubMed ID: 18076381

DOI: 10.1042/bj20071334

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 890
  • Mass: 100471
  • Checksum: 66D5E7E7235064F5
  • Sequence:
    • MSANNSPPSA QKSVLPTAIP AVLPAASPCS SPKTGLSARL SNGSFSAPSL TNSRGSVHTV 
SFLLQIGLTR ESVTIEAQEL SLSAVKDLVC SIVYQKFPEC GFFGMYDKIL LFRHDMNSEN 
ILQLITSADE IHEGDLVEVV LSALATVEDF QIRPHTLYVH SYKAPTFCDY CGEMLWGLVR 
QGLKCEGCGL NYHKRCAFKI PNNCSGVRKR RLSNVSLPGP GLSVPRPLQP EYVALPSEES 
HVHQEPSKRI PSWSGRPIWM EKMVMCRVKV PHTFAVHSYT RPTICQYCKR LLKGLFRQGM 
QCKDCKFNCH KRCASKVPRD CLGEVTFNGE PSSLGTDTDI PMDIDNNDIN SDSSRGLDDT 
EEPSPPEDKM FFLDPSDLDV ERDEEAVKTI SPSTSNNIPL MRVVQSIKHT KRKSSTMVKE 
GWMVHYTSRD NLRKRHYWRL DSKCLTLFQN ESGSKYYKEI PLSEILRISS PRDFTNISQG 
SNPHCFEIIT DTMVYFVGEN NGDSSHNPVL AATGVGLDVA QSWEKAIRQA LMPVTPQASV 
CTSPGQGKDH KDLSTSISVS NCQIQENVDI STVYQIFADE VLGSGQFGIV YGGKHRKTGR 
DVAIKVIDKM RFPTKQESQL RNEVAILQNL HHPGIVNLEC MFETPERVFV VMEKLHGDML 
EMILSSEKSR LPERITKFMV TQILVALRNL HFKNIVHCDL KPENVLLASA EPFPQVKLCD 
FGFARIIGEK SFRRSVVGTP AYLAPEVLRS KGYNRSLDMW SVGVIIYVSL SGTFPFNEDE 
DINDQIQNAA FMYPPNPWRE ISGEAIDLIN NLLQVKMRKR YSVDKSLSHP WLQDYQTWLD 
LREFETRIGE RYITHESDDA RWEIHAYTHN LVYPKHFIMA PNPDDMEEDP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.