Details for: KCNE4

Gene ID: 23704

Symbol: KCNE4

Ensembl ID: ENSG00000152049

Description: potassium voltage-gated channel subfamily E regulatory subunit 4

Associated with

  • Cardiac conduction
    (R-HSA-5576891)
  • Muscle contraction
    (R-HSA-397014)
  • Phase 2 - plateau phase
    (R-HSA-5576893)
  • Phase 3 - rapid repolarisation
    (R-HSA-5576890)
  • Apical plasma membrane
    (GO:0016324)
  • Delayed rectifier potassium channel activity
    (GO:0005251)
  • Membrane repolarization during action potential
    (GO:0086011)
  • Membrane repolarization during ventricular cardiac muscle cell action potential
    (GO:0098915)
  • Monoatomic ion channel complex
    (GO:0034702)
  • Negative regulation of delayed rectifier potassium channel activity
    (GO:1902260)
  • Potassium channel regulator activity
    (GO:0015459)
  • Potassium ion export across plasma membrane
    (GO:0097623)
  • Protein binding
    (GO:0005515)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Transmembrane transporter binding
    (GO:0044325)
  • Ventricular cardiac muscle cell action potential
    (GO:0086005)
  • Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
    (GO:1902282)

Other Information

Genular Protein ID: 3988464530

Symbol: KCNE4_HUMAN

Name: MinK-related peptide 3

UniProtKB Accession Codes:

Q8WWG9 A5H1P5 B7Z275 Q53SM4 Q96CC4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 Ensembl 1 GO 11 GeneCards 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12096056

Title: KCNE4 is an inhibitory subunit to the KCNQ1 channel.

PubMed ID: 12096056

DOI: 10.1113/jphysiol.2002.017301

PubMed ID: 19687231

Title: Distinct subdomains of the KCNQ1 S6 segment determine channel modulation by different KCNE subunits.

PubMed ID: 19687231

DOI: 10.1085/jgp.200910234

PubMed ID: 20533308

Title: Impact of KCNE subunits on KCNQ1 (Kv7.1) channel membrane surface targeting.

PubMed ID: 20533308

DOI: 10.1002/jcp.22265

PubMed ID: 27162025

Title: Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.

PubMed ID: 27162025

DOI: 10.1096/fj.201600467r

Sequence Information:

  • Length: 221
  • Mass: 23806
  • Checksum: F601434C18E82CFE
  • Sequence:
    • MHFLTIYPNC SSGVVRAQSR TEQKNPLGLD DLGIQNLGQT VSLAPAVEAA SMLKMEPLNS 
THPGTAASSS PLESRAAGGG SGNGNEYFYI LVVMSFYGIF LIGIMLGYMK SKRREKKSSL 
LLLYKDEERL WGEAMKPLPV VSGLRSVQVP LMLNMLQESV APALSCTLCS MEGDSVSSES 
SSPDVHLTIQ EEGADDELEE TSETPLNESS EGSSENIHQN S

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.