Details for: GSPT2

Gene ID: 23708

Symbol: GSPT2

Ensembl ID: ENSG00000189369

Description: G1 to S phase transition 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.61
    Marker Score: 3,745
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.1
    Marker Score: 883
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,001
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,234
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,723
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.89
    Marker Score: 262
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.88
    Marker Score: 354
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,265
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.82
    Marker Score: 1,439
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 376
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.71
    Marker Score: 982
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.69
    Marker Score: 525
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.68
    Marker Score: 245
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,797
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.66
    Marker Score: 644
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.64
    Marker Score: 151
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.64
    Marker Score: 3,818
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.63
    Marker Score: 635
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.63
    Marker Score: 425
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.62
    Marker Score: 664
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.62
    Marker Score: 331
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.61
    Marker Score: 296
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6
    Marker Score: 1,212
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 377
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.58
    Marker Score: 318
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.57
    Marker Score: 610
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.56
    Marker Score: 595
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.55
    Marker Score: 314
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.54
    Marker Score: 1,134
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 432
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.53
    Marker Score: 748
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.53
    Marker Score: 177
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.52
    Marker Score: 346
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.51
    Marker Score: 341
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.51
    Marker Score: 1,378
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.49
    Marker Score: 1,823
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.48
    Marker Score: 517
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.47
    Marker Score: 142
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.47
    Marker Score: 1,286
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.47
    Marker Score: 4,750
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.46
    Marker Score: 579
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.46
    Marker Score: 3,005
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.46
    Marker Score: 555
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.45
    Marker Score: 545
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.44
    Marker Score: 414
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.44
    Marker Score: 5,760
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.44
    Marker Score: 151
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.44
    Marker Score: 411
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.43
    Marker Score: 1,749
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.43
    Marker Score: 258
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.42
    Marker Score: 287
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.42
    Marker Score: 250
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.42
    Marker Score: 491
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.41
    Marker Score: 704
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 189
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.41
    Marker Score: 192
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 167
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.4
    Marker Score: 226
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4
    Marker Score: 91
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.39
    Marker Score: 269
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.39
    Marker Score: 160
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.39
    Marker Score: 259
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.38
    Marker Score: 110
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.37
    Marker Score: 470
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.37
    Marker Score: 791
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.37
    Marker Score: 182
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.36
    Marker Score: 156
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.36
    Marker Score: 480
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.36
    Marker Score: 3,063
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.36
    Marker Score: 4,008
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.36
    Marker Score: 837
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.36
    Marker Score: 187
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.35
    Marker Score: 175
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.35
    Marker Score: 805
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.35
    Marker Score: 221
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.35
    Marker Score: 86
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.34
    Marker Score: 360
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.34
    Marker Score: 213
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.34
    Marker Score: 136
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5,254
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.33
    Marker Score: 116
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.33
    Marker Score: 184
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.32
    Marker Score: 2,097
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.32
    Marker Score: 732
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.32
    Marker Score: 202

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Cycle Regulation:** GSPT2 is involved in the transition from the G1 to S phase of the cell cycle, a critical step in DNA replication and cell division. 2. **Translation Termination:** GSPT2 is a GTP-binding protein that regulates the termination of protein synthesis, ensuring accurate translation termination and preventing aberrant protein production. 3. **Nonsense-Mediated Decay (NMD):** GSPT2 is a component of the NMD pathway, which detects and degrades aberrant mRNAs containing premature stop codons, thereby maintaining genome stability. 4. **Axon Guidance:** GSPT2 is involved in axon guidance, a process critical for the formation and maintenance of neural connections during development. **Pathways and Functions:** 1. **Cell Cycle Regulation:** GSPT2 interacts with other proteins to regulate the transition from the G1 to S phase, ensuring proper cell cycle progression. 2. **Translation Termination:** GSPT2 regulates the release of translation termination factors, ensuring accurate termination of protein synthesis. 3. **Nonsense-Mediated Decay (NMD):** GSPT2 is a key component of the NMD pathway, which detects and degrades aberrant mRNAs containing premature stop codons. 4. **Axon Guidance:** GSPT2 interacts with other proteins to regulate axon guidance, a process critical for neural development and maintenance. **Clinical Significance:** Dysregulation of the GSPT2 gene has been linked to various diseases, including: 1. **Cancer:** GSPT2 mutations have been identified in various types of cancer, including breast, lung, and colon cancer. 2. **Neurological Disorders:** GSPT2 mutations have been linked to neurological disorders, including Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Developmental Disorders:** GSPT2 mutations have been identified in individuals with developmental disorders, including autism spectrum disorder and intellectual disability. In conclusion, the GSPT2 gene plays a critical role in regulating cell cycle progression, translation termination, and nonsense-mediated decay. Its dysregulation has significant clinical implications, making it a potential target for therapeutic intervention in various diseases. Further research is needed to fully understand the functions of GSPT2 and its role in human disease.

Genular Protein ID: 2456265279

Symbol: ERF3B_HUMAN

Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

UniProtKB Accession Codes:

Q8IYD1 Q9H909 Q9NVY0 Q9NY44

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 2 SAM 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11524954

Title: Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo.

PubMed ID: 11524954

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15987998

Title: Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.

PubMed ID: 15987998

DOI: 10.1128/mcb.25.14.5801-5811.2005

PubMed ID: 16721809

Title: Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III.

PubMed ID: 16721809

DOI: 10.1002/ijc.22027

PubMed ID: 17562865

Title: Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway.

PubMed ID: 17562865

DOI: 10.1128/mcb.00035-07

PubMed ID: 18447585

Title: A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.

PubMed ID: 18447585

DOI: 10.1371/journal.pbio.0060111

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20418951

Title: Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein.

PubMed ID: 20418951

DOI: 10.1371/journal.pone.0010169

Sequence Information:

  • Length: 628
  • Mass: 68883
  • Checksum: 909FCDEF04EC89C9
  • Sequence:
    • MDSGSSSSDS APDCWDQVDM ESPGSAPSGD GVSSAVAEAQ REPLSSAFSR KLNVNAKPFV 
PNVHAAEFVP SFLRGPTQPP TLPAGSGSND ETCTGAGYPQ GKRMGRGAPV EPSREEPLVS 
LEGSNSAVTM ELSEPVVENG EVEMALEESW EHSKEVSEAE PGGGSSGDSG PPEESGQEMM 
EEKEEIRKSK SVIVPSGAPK KEHVNVVFIG HVDAGKSTIG GQIMFLTGMV DKRTLEKYER 
EAKEKNRETW YLSWALDTNQ EERDKGKTVE VGRAYFETER KHFTILDAPG HKSFVPNMIG 
GASQADLAVL VISARKGEFE TGFEKGGQTR EHAMLAKTAG VKHLIVLINK MDDPTVNWSI 
ERYEECKEKL VPFLKKVGFS PKKDIHFMPC SGLTGANIKE QSDFCPWYTG LPFIPYLDNL 
PNFNRSIDGP IRLPIVDKYK DMGTVVLGKL ESGSIFKGQQ LVMMPNKHNV EVLGILSDDT 
ETDFVAPGEN LKIRLKGIEE EEILPGFILC DPSNLCHSGR TFDVQIVIIE HKSIICPGYN 
AVLHIHTCIE EVEITALISL VDKKSGEKSK TRPRFVKQDQ VCIARLRTAG TICLETFKDF 
PQMGRFTLRD EGKTIAIGKV LKLVPEKD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.