GSPT2 | ENSG00000189369 | NCBI 23708

Details for: GSPT2

Gene ID: 23708

Symbol: GSPT2

Ensembl ID: ENSG00000189369

Description: G1 to S phase transition 2

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Eukaryotic translation termination
(R-HSA-72764)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Nervous system development
(R-HSA-9675108)
Nonsense-mediated decay (nmd)
(R-HSA-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-HSA-975957)
Nonsense mediated decay (nmd) independent of the exon junction complex (ejc)
(R-HSA-975956)
Regulation of expression of slits and robos
(R-HSA-9010553)
Signaling by robo receptors
(R-HSA-376176)
Cell cycle
(GO:0007049)
Cytosol
(GO:0005829)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Translation
(GO:0006412)
Translational termination
(GO:0006415)
Translation release factor activity
(GO:0003747)
Translation release factor complex
(GO:0018444)

Other Information

Proteins

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

Genular Protein ID: 2456265279

Symbol: ERF3B_HUMAN

Name: Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

UniProtKB Accession Codes:

Q8IYD1 Q9H909 Q9NVY0 Q9NY44

Database IDs:

Citations:

PubMed ID: 11524954

Title: Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo.

PubMed ID: 11524954

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15987998

Title: Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation.

PubMed ID: 15987998

DOI: 10.1128/mcb.25.14.5801-5811.2005

PubMed ID: 16721809

Title: Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III.

PubMed ID: 16721809

DOI: 10.1002/ijc.22027

PubMed ID: 17562865

Title: Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway.

PubMed ID: 17562865

DOI: 10.1128/mcb.00035-07

PubMed ID: 18447585

Title: A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay.

PubMed ID: 18447585

DOI: 10.1371/journal.pbio.0060111

PubMed ID: 19417104

Title: SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.

PubMed ID: 19417104

DOI: 10.1101/gad.1767209

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20418951

Title: Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein.

PubMed ID: 20418951

DOI: 10.1371/journal.pone.0010169

Sequence Information:

Length: 628
Mass: 68883
Checksum: 909FCDEF04EC89C9
Sequence:

MDSGSSSSDS APDCWDQVDM ESPGSAPSGD GVSSAVAEAQ REPLSSAFSR KLNVNAKPFV 
PNVHAAEFVP SFLRGPTQPP TLPAGSGSND ETCTGAGYPQ GKRMGRGAPV EPSREEPLVS 
LEGSNSAVTM ELSEPVVENG EVEMALEESW EHSKEVSEAE PGGGSSGDSG PPEESGQEMM 
EEKEEIRKSK SVIVPSGAPK KEHVNVVFIG HVDAGKSTIG GQIMFLTGMV DKRTLEKYER 
EAKEKNRETW YLSWALDTNQ EERDKGKTVE VGRAYFETER KHFTILDAPG HKSFVPNMIG 
GASQADLAVL VISARKGEFE TGFEKGGQTR EHAMLAKTAG VKHLIVLINK MDDPTVNWSI 
ERYEECKEKL VPFLKKVGFS PKKDIHFMPC SGLTGANIKE QSDFCPWYTG LPFIPYLDNL 
PNFNRSIDGP IRLPIVDKYK DMGTVVLGKL ESGSIFKGQQ LVMMPNKHNV EVLGILSDDT 
ETDFVAPGEN LKIRLKGIEE EEILPGFILC DPSNLCHSGR TFDVQIVIIE HKSIICPGYN 
AVLHIHTCIE EVEITALISL VDKKSGEKSK TRPRFVKQDQ VCIARLRTAG TICLETFKDF 
PQMGRFTLRD EGKTIAIGKV LKLVPEKD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GSPT2

Associated with

Other Information

Identification of a novel termination release factor eRF3b expressing the eRF3 activity in vitro and in vivo. PubMed ID: 11524954

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation. PubMed ID: 15987998

Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III. PubMed ID: 16721809

Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway. PubMed ID: 17562865

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. PubMed ID: 18447585

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. PubMed ID: 19417104

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein. PubMed ID: 20418951