Details for: GABARAPL1

Gene ID: 23710

Symbol: GABARAPL1

Ensembl ID: ENSG00000139112

Description: GABA type A receptor associated protein like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.04
    Marker Score: 3,677
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3
    Marker Score: 6,342
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3
    Marker Score: 2,555
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.7
    Marker Score: 2,887
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.7
    Marker Score: 2,543
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.67
    Marker Score: 2,828
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.61
    Marker Score: 5,311
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.57
    Marker Score: 87,605
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.34
    Marker Score: 6,684
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.31
    Marker Score: 960
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.22
    Marker Score: 3,680
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.09
    Marker Score: 8,201
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2
    Marker Score: 595
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.98
    Marker Score: 12,018
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.93
    Marker Score: 480
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.92
    Marker Score: 5,145
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.91
    Marker Score: 480
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.89
    Marker Score: 5,209
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.83
    Marker Score: 4,618
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.83
    Marker Score: 975
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.83
    Marker Score: 5,128
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.82
    Marker Score: 1,060
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.81
    Marker Score: 417
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.74
    Marker Score: 7,521
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.74
    Marker Score: 509
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.74
    Marker Score: 2,564
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.74
    Marker Score: 44,579
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.71
    Marker Score: 2,420
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.69
    Marker Score: 966
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.68
    Marker Score: 2,438
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.68
    Marker Score: 4,096
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.67
    Marker Score: 1,408
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.65
    Marker Score: 5,213
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.59
    Marker Score: 3,629
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.59
    Marker Score: 3,486
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.51
    Marker Score: 1,723
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.5
    Marker Score: 1,178
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.5
    Marker Score: 2,665
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.5
    Marker Score: 15,463
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.49
    Marker Score: 1,175
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.49
    Marker Score: 1,565
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.47
    Marker Score: 6,171
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166,196
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.45
    Marker Score: 986
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.42
    Marker Score: 1,965
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.42
    Marker Score: 5,043
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.42
    Marker Score: 12,173
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.41
    Marker Score: 86,718
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.41
    Marker Score: 358
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.4
    Marker Score: 472
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.4
    Marker Score: 346
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.39
    Marker Score: 732
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.36
    Marker Score: 990
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.35
    Marker Score: 524
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.35
    Marker Score: 550
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.33
    Marker Score: 1,147
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.32
    Marker Score: 3,468
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.32
    Marker Score: 29,575
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.32
    Marker Score: 1,271
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.31
    Marker Score: 12,431
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.31
    Marker Score: 6,412
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.29
    Marker Score: 409
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.29
    Marker Score: 4,773
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.29
    Marker Score: 2,179
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.29
    Marker Score: 553
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.29
    Marker Score: 1,985
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.29
    Marker Score: 4,565
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.26
    Marker Score: 5,253
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.24
    Marker Score: 1,338
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.24
    Marker Score: 4,783
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.24
    Marker Score: 1,453
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.24
    Marker Score: 279
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.23
    Marker Score: 634
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.23
    Marker Score: 68,589
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.22
    Marker Score: 282
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.22
    Marker Score: 704
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.22
    Marker Score: 3,098
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.22
    Marker Score: 1,368
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.22
    Marker Score: 1,236
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 830
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.21
    Marker Score: 11,405
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 1.21
    Marker Score: 290
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.2
    Marker Score: 1,449
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.2
    Marker Score: 286
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.2
    Marker Score: 44,120
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.19
    Marker Score: 1,241
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.19
    Marker Score: 284
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.18
    Marker Score: 2,855
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.18
    Marker Score: 536
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.17
    Marker Score: 1,050
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.17
    Marker Score: 546
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.16
    Marker Score: 893
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.16
    Marker Score: 365
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.15
    Marker Score: 1,447
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.15
    Marker Score: 501
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.15
    Marker Score: 1,486
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.15
    Marker Score: 476
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.14
    Marker Score: 477
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.14
    Marker Score: 1,585
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.14
    Marker Score: 291

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Autophagy-related functions:** GABARAPL1 is implicated in the regulation of autophagy, a process that involves the formation and maturation of autophagosomes, which are double-membraned structures responsible for engulfing and degrading cellular components. 2. **Cellular localization:** GABARAPL1 is primarily localized to the cytosol and endoplasmic reticulum, where it interacts with other autophagy-related proteins to regulate autophagosome formation and maturation. 3. **Protein interactions:** GABARAPL1 interacts with various proteins, including GBRL1, a protein involved in the regulation of estrogen signaling, highlighting the gene's potential role in cellular responses to hormonal cues. 4. **Expression in different cell types:** GABARAPL1 is expressed in a wide range of cell types, including neurons, muscle cells, epithelial cells, and fibroblasts, underscoring its importance in maintaining cellular homeostasis across different tissues. **Pathways and Functions:** 1. **Autophagosome formation and maturation:** GABARAPL1 is involved in the regulation of autophagosome formation and maturation, which is critical for the degradation and recycling of cellular components. 2. **Cellular response to nitrogen starvation:** GABARAPL1 is also implicated in the cellular response to nitrogen starvation, a condition that can lead to autophagy and cellular stress. 3. **GABA receptor binding:** GABARAPL1 interacts with GABA receptors, which are critical for neuronal function and synaptic transmission. 4. **Glycophagy and macroautophagy:** GABARAPL1 is involved in glycophagy, a process that involves the degradation of glycans, and macroautophagy, a process that involves the degradation of large cellular components. **Clinical Significance:** 1. **Autophagy-related disorders:** Alterations in GABARAPL1 expression have been linked to autophagy-related disorders, including neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 2. **Cancer:** GABARAPL1 has been implicated in cancer, where it may play a role in the regulation of autophagy and cellular metabolism. 3. **Neurological disorders:** GABARAPL1 has been linked to neurological disorders, including epilepsy and schizophrenia, where it may play a role in the regulation of neuronal function and synaptic transmission. 4. **Protein homeostasis:** GABARAPL1 is involved in maintaining protein homeostasis, which is critical for cellular function and survival. In conclusion, GABARAPL1 is a critical gene that plays a vital role in autophagy and cellular regulation. Its dysregulation has been linked to various diseases, highlighting the need for further research into the functions and mechanisms of this gene.

Genular Protein ID: 4264757766

Symbol: GBRL1_HUMAN

Name: Early estrogen-regulated protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11374880

Title: A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP.

PubMed ID: 11374880

DOI: 10.1006/bbrc.2001.4908

PubMed ID: 11414770

Title: Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.

PubMed ID: 11414770

DOI: 10.1006/geno.2001.6555

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16431922

Title: GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor.

PubMed ID: 16431922

DOI: 10.1074/jbc.m509805200

PubMed ID: 17580304

Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

PubMed ID: 17580304

DOI: 10.1074/jbc.m702824200

PubMed ID: 20404487

Title: GABARAPL1 (GEC1) associates with autophagic vesicles.

PubMed ID: 20404487

DOI: 10.4161/auto.6.4.11819

PubMed ID: 20562859

Title: Network organization of the human autophagy system.

PubMed ID: 20562859

DOI: 10.1038/nature09204

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22948227

Title: MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.

PubMed ID: 22948227

DOI: 10.4161/auto.21857

PubMed ID: 23043107

Title: ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.

PubMed ID: 23043107

DOI: 10.1074/jbc.m112.378109

PubMed ID: 22354992

Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.

PubMed ID: 22354992

DOI: 10.1128/mcb.06717-11

PubMed ID: 22470510

Title: DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.

PubMed ID: 22470510

DOI: 10.1371/journal.pone.0034034

PubMed ID: 23112293

Title: The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.

PubMed ID: 23112293

DOI: 10.1126/science.1227026

PubMed ID: 23690988

Title: Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1.

PubMed ID: 23690988

DOI: 10.1371/journal.pone.0063133

PubMed ID: 25127057

Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

PubMed ID: 25127057

DOI: 10.1016/j.devcel.2014.06.013

PubMed ID: 24668264

Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

PubMed ID: 24668264

DOI: 10.1002/embr.201338003

PubMed ID: 26347139

Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

PubMed ID: 26347139

DOI: 10.1083/jcb.201503023

PubMed ID: 26355087

Title: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway.

PubMed ID: 26355087

DOI: 10.1128/jvi.01482-15

PubMed ID: 25684205

Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

PubMed ID: 25684205

DOI: 10.1016/j.molcel.2014.12.040

PubMed ID: 26929408

Title: Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.

PubMed ID: 26929408

DOI: 10.1074/jbc.m116.715474

PubMed ID: 29458288

Title: Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.

PubMed ID: 29458288

DOI: 10.1080/15548627.2018.1437341

PubMed ID: 29420192

Title: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.

PubMed ID: 29420192

DOI: 10.1083/jcb.201708039

PubMed ID: 30661429

Title: Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.

PubMed ID: 30661429

DOI: 10.1080/15548627.2019.1569925

PubMed ID: 31006538

Title: Intrinsically disordered protein TEX264 mediates ER-phagy.

PubMed ID: 31006538

DOI: 10.1016/j.molcel.2019.03.033

PubMed ID: 31006537

Title: TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress.

PubMed ID: 31006537

DOI: 10.1016/j.molcel.2019.03.034

PubMed ID: 31722778

Title: LIR motifs and the membrane-targeting domain are complementary in the function of RavZ.

PubMed ID: 31722778

DOI: 10.5483/bmbrep.2019.52.12.211

PubMed ID: 32315611

Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.

PubMed ID: 32315611

DOI: 10.1016/j.devcel.2020.03.018

PubMed ID: 34338405

Title: Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.

PubMed ID: 34338405

DOI: 10.15252/embr.202052289

PubMed ID: 33909989

Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.

PubMed ID: 33909989

DOI: 10.1016/j.molcel.2021.03.020

PubMed ID: 28287329

Title: ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.

PubMed ID: 28287329

DOI: 10.1080/15548627.2017.1287651

Sequence Information:

  • Length: 117
  • Mass: 14044
  • Checksum: 7F56E345255F564B
  • Sequence:
  • MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF 
    YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.