Details for: GABARAPL1
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.04
Marker Score: 3,677 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3
Marker Score: 6,342 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3
Marker Score: 2,555 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.7
Marker Score: 2,887 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.7
Marker Score: 2,543 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.67
Marker Score: 2,828 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.61
Marker Score: 5,311 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.57
Marker Score: 87,605 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.34
Marker Score: 6,684 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.31
Marker Score: 960 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.22
Marker Score: 3,680 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.09
Marker Score: 8,201 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 2
Marker Score: 595 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.98
Marker Score: 12,018 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.93
Marker Score: 480 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.92
Marker Score: 5,145 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.91
Marker Score: 480 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 1.89
Marker Score: 5,209 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.83
Marker Score: 4,618 - Cell Name: renal intercalated cell (CL0005010)
Fold Change: 1.83
Marker Score: 975 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.83
Marker Score: 5,128 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.82
Marker Score: 1,060 - Cell Name: keratocyte (CL0002363)
Fold Change: 1.81
Marker Score: 417 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.74
Marker Score: 7,521 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.74
Marker Score: 509 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.74
Marker Score: 2,564 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.74
Marker Score: 44,579 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.71
Marker Score: 2,420 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.69
Marker Score: 966 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.68
Marker Score: 2,438 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.68
Marker Score: 4,096 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 1.67
Marker Score: 1,408 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.65
Marker Score: 5,213 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.59
Marker Score: 3,629 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.59
Marker Score: 3,486 - Cell Name: lung macrophage (CL1001603)
Fold Change: 1.51
Marker Score: 1,723 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 1.5
Marker Score: 1,178 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.5
Marker Score: 2,665 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.5
Marker Score: 15,463 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.49
Marker Score: 1,175 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.49
Marker Score: 1,565 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.47
Marker Score: 6,171 - Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166,196 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.45
Marker Score: 986 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.42
Marker Score: 1,965 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.42
Marker Score: 5,043 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.42
Marker Score: 12,173 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.41
Marker Score: 86,718 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.41
Marker Score: 358 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.4
Marker Score: 472 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.4
Marker Score: 346 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.39
Marker Score: 732 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.36
Marker Score: 990 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.35
Marker Score: 524 - Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.35
Marker Score: 550 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 1.33
Marker Score: 1,147 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.32
Marker Score: 3,468 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.32
Marker Score: 29,575 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.32
Marker Score: 1,271 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.31
Marker Score: 12,431 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.31
Marker Score: 6,412 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.29
Marker Score: 409 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.29
Marker Score: 4,773 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.29
Marker Score: 2,179 - Cell Name: memory T cell (CL0000813)
Fold Change: 1.29
Marker Score: 553 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.29
Marker Score: 1,985 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.29
Marker Score: 4,565 - Cell Name: classical monocyte (CL0000860)
Fold Change: 1.26
Marker Score: 5,253 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.24
Marker Score: 1,338 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.24
Marker Score: 4,783 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.24
Marker Score: 1,453 - Cell Name: PP cell (CL0000696)
Fold Change: 1.24
Marker Score: 279 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.23
Marker Score: 634 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.23
Marker Score: 68,589 - Cell Name: B-1b B cell (CL0000821)
Fold Change: 1.22
Marker Score: 282 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.22
Marker Score: 704 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.22
Marker Score: 3,098 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.22
Marker Score: 1,368 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.22
Marker Score: 1,236 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.22
Marker Score: 830 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.21
Marker Score: 11,405 - Cell Name: B-1a B cell (CL0000820)
Fold Change: 1.21
Marker Score: 290 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.2
Marker Score: 1,449 - Cell Name: centrocyte (CL0009111)
Fold Change: 1.2
Marker Score: 286 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.2
Marker Score: 44,120 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.19
Marker Score: 1,241 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.19
Marker Score: 284 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.18
Marker Score: 2,855 - Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
Fold Change: 1.18
Marker Score: 536 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.17
Marker Score: 1,050 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.17
Marker Score: 546 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.16
Marker Score: 893 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.16
Marker Score: 365 - Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.15
Marker Score: 1,447 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 1.15
Marker Score: 501 - Cell Name: basal cell (CL0000646)
Fold Change: 1.15
Marker Score: 1,486 - Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.15
Marker Score: 476 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.14
Marker Score: 477 - Cell Name: Mueller cell (CL0000636)
Fold Change: 1.14
Marker Score: 1,585 - Cell Name: pre-B-I cell (CL0000956)
Fold Change: 1.14
Marker Score: 291
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4264757766
Symbol: GBRL1_HUMAN
Name: Early estrogen-regulated protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11374880
Title: A novel early estrogen-regulated gene gec1 encodes a protein related to GABARAP.
PubMed ID: 11374880
PubMed ID: 11414770
Title: Cloning, expression patterns, and chromosome localization of three human and two mouse homologues of GABA(A) receptor-associated protein.
PubMed ID: 11414770
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16431922
Title: GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor.
PubMed ID: 16431922
PubMed ID: 17580304
Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
PubMed ID: 17580304
PubMed ID: 20404487
Title: GABARAPL1 (GEC1) associates with autophagic vesicles.
PubMed ID: 20404487
PubMed ID: 20562859
Title: Network organization of the human autophagy system.
PubMed ID: 20562859
DOI: 10.1038/nature09204
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22948227
Title: MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
PubMed ID: 22948227
DOI: 10.4161/auto.21857
PubMed ID: 23043107
Title: ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.
PubMed ID: 23043107
PubMed ID: 22354992
Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
PubMed ID: 22354992
DOI: 10.1128/mcb.06717-11
PubMed ID: 22470510
Title: DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
PubMed ID: 22470510
PubMed ID: 23112293
Title: The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.
PubMed ID: 23112293
PubMed ID: 23690988
Title: Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1.
PubMed ID: 23690988
PubMed ID: 25127057
Title: TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
PubMed ID: 25127057
PubMed ID: 24668264
Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
PubMed ID: 24668264
PubMed ID: 26347139
Title: TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
PubMed ID: 26347139
PubMed ID: 26355087
Title: Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway.
PubMed ID: 26355087
DOI: 10.1128/jvi.01482-15
PubMed ID: 25684205
Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
PubMed ID: 25684205
PubMed ID: 26929408
Title: Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.
PubMed ID: 26929408
PubMed ID: 29458288
Title: Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.
PubMed ID: 29458288
PubMed ID: 29420192
Title: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
PubMed ID: 29420192
PubMed ID: 30661429
Title: Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.
PubMed ID: 30661429
PubMed ID: 31006538
Title: Intrinsically disordered protein TEX264 mediates ER-phagy.
PubMed ID: 31006538
PubMed ID: 31006537
Title: TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress.
PubMed ID: 31006537
PubMed ID: 31722778
Title: LIR motifs and the membrane-targeting domain are complementary in the function of RavZ.
PubMed ID: 31722778
PubMed ID: 32315611
Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.
PubMed ID: 32315611
PubMed ID: 34338405
Title: Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.
PubMed ID: 34338405
PubMed ID: 33909989
Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
PubMed ID: 33909989
PubMed ID: 28287329
Title: ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8.
PubMed ID: 28287329
Sequence Information:
- Length: 117
- Mass: 14044
- Checksum: 7F56E345255F564B
- Sequence:
MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.