Details for: SHPK

Gene ID: 23729

Symbol: SHPK

Ensembl ID: ENSG00000197417

Description: sedoheptulokinase

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.05
    Marker Score: 6,317
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.79
    Marker Score: 625
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.04
    Marker Score: 1,973
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.04
    Marker Score: 1,084
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16,103
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20,180
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2,220
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,307
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1,830
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 314
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,278
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.86
    Marker Score: 360
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 686
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.74
    Marker Score: 661
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.71
    Marker Score: 6,723
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.69
    Marker Score: 5,906
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.68
    Marker Score: 522
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.68
    Marker Score: 186
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.68
    Marker Score: 273
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2,809
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.64
    Marker Score: 2,675
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.64
    Marker Score: 6,013
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.63
    Marker Score: 979
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.62
    Marker Score: 2,396
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.61
    Marker Score: 37,242
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.59
    Marker Score: 21,658
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 334
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.52
    Marker Score: 4,019
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.52
    Marker Score: 1,478
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.52
    Marker Score: 165
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7,752
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.52
    Marker Score: 19,595
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.51
    Marker Score: 386
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.5
    Marker Score: 344
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 238
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 326
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.49
    Marker Score: 9,721
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.46
    Marker Score: 212
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.41
    Marker Score: 182
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.4
    Marker Score: 1,672
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.4
    Marker Score: 117
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.37
    Marker Score: 144
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.37
    Marker Score: 205
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.36
    Marker Score: 354
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.35
    Marker Score: 1,359
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.33
    Marker Score: 2,212
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.32
    Marker Score: 338
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.32
    Marker Score: 84
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.32
    Marker Score: 341
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 77
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.3
    Marker Score: 319
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.29
    Marker Score: 221
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 149
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.28
    Marker Score: 277
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.27
    Marker Score: 312
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.27
    Marker Score: 143
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.27
    Marker Score: 63
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.27
    Marker Score: 323
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.26
    Marker Score: 439
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.25
    Marker Score: 1,193
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.25
    Marker Score: 85
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.24
    Marker Score: 161
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.24
    Marker Score: 561
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.24
    Marker Score: 130
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.23
    Marker Score: 58
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.23
    Marker Score: 476
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.23
    Marker Score: 175
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.22
    Marker Score: 233
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.21
    Marker Score: 218
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.21
    Marker Score: 318
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.21
    Marker Score: 140
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.2
    Marker Score: 189
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2
    Marker Score: 218
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.2
    Marker Score: 131
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.19
    Marker Score: 685
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.19
    Marker Score: 61
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.19
    Marker Score: 293
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.18
    Marker Score: 1,557
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.18
    Marker Score: 172
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 80

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Sedoheptulokinase is a carbohydrate kinase enzyme that belongs to the sedoheptulokinase family. It is characterized by its ability to catalyze the conversion of sedoheptulose-7-phosphate to sedoheptulose-6-phosphate. This enzyme is highly expressed in various tissues, including the kidney, liver, and immune cells, such as macrophages and T lymphocytes. Sedoheptulokinase has been identified in multiple cell types, including epithelial cells, endothelial cells, and stem cells, highlighting its broad tissue distribution. **Pathways and Functions:** Sedoheptulokinase is involved in several key metabolic pathways, including: 1. **Pentose Phosphate Pathway (PPP):** Sedoheptulokinase catalyzes the conversion of sedoheptulose-7-phosphate to sedoheptulose-6-phosphate, a critical step in the PPP. 2. **Glycerol Metabolism:** Sedoheptulokinase has been implicated in the regulation of glycerol metabolism, influencing the production of glycerol-3-phosphate. 3. **Antioxidant Defense:** The PPP, in which sedoheptulokinase plays a key role, is a major source of NADPH, which serves as a reducing agent in antioxidant defenses. 4. **Inflammatory Response:** Sedoheptulokinase has been shown to regulate macrophage activation and the response to inflammatory stimuli, highlighting its role in immune regulation. **Clinical Significance:** Dysregulation of sedoheptulokinase has been implicated in various diseases, including: 1. **Metabolic Disorders:** Sedoheptulokinase deficiency has been associated with impaired carbohydrate metabolism and insulin resistance. 2. **Inflammatory Diseases:** Abnormal sedoheptulokinase activity has been linked to inflammatory disorders, such as atherosclerosis and rheumatoid arthritis. 3. **Cancer:** Sedoheptulokinase has been implicated in cancer development and progression, possibly through its role in glycolysis and energy metabolism. In conclusion, sedoheptulokinase is a critical enzyme involved in carbohydrate metabolism and immune regulation. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this enzyme.

Genular Protein ID: 2316469479

Symbol: SHPK_HUMAN

Name: Carbohydrate kinase-like protein

UniProtKB Accession Codes:

Q9UHJ6 B2R640 Q8WUH3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 5 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 EPD 1 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 2 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10673275

Title: The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion.

PubMed ID: 10673275

DOI: 10.1101/gr.10.2.165

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18186520

Title: Sedoheptulokinase deficiency due to a 57-kb deletion in cystinosis patients causes urinary accumulation of sedoheptulose: elucidation of the CARKL gene.

PubMed ID: 18186520

DOI: 10.1002/humu.20685

PubMed ID: 22682222

Title: The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.

PubMed ID: 22682222

DOI: 10.1016/j.cmet.2012.04.023

PubMed ID: 25647543

Title: First two unrelated cases of isolated sedoheptulokinase deficiency: A benign disorder?

PubMed ID: 25647543

DOI: 10.1007/s10545-014-9809-1

Sequence Information:

  • Length: 478
  • Mass: 51505
  • Checksum: 0C930B380826AC1E
  • Sequence:
    • MAARPITLGI DLGTTSVKAA LLRAAPDDPS GFAVLASCAR AARAEAAVES AVAGPQGREQ 
DVSRILQALH ECLAALPRPQ LRSVVGIGVS GQMHGVVFWK TGQGCEWTEG GITPVFEPRA 
VSHLVTWQDG RCSSEFLASL PQPKSHLSVA TGFGCATIFW LLKYRPEFLK SYDAAGTIHD 
YVVAMLCGLP RPLMSDQNAA SWGYFNTQSQ SWNVETLRSS GFPVHLLPDI AEPGSVAGRT 
SHMWFEIPKG TQVGVALGDL QASVYSCMAQ RTDAVLNIST SVQLAASMPS GFQPAQTPDP 
TAPVAYFPYF NRTYLGVAAS LNGGNVLATF VHMLVQWMAD LGLEVEESTV YSRMIQAAVQ 
QRDTHLTITP TVLGERHLPD QLASVTRISS SDLSLGHVTR ALCRGIVQNL HSMLPIQQLQ 
EWGVERVMGS GSALSRNDVL KQEVQRAFPL PMSFGQDVDA AVGAALVMLR RHLNQKES

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.