Details for: TMEM245

Gene ID: 23731

Symbol: TMEM245

Ensembl ID: ENSG00000106771

Description: transmembrane protein 245

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.67
    Marker Score: 82,949
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.4
    Marker Score: 14,181
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.57
    Marker Score: 2,112
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.57
    Marker Score: 10,755
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.44
    Marker Score: 3,283
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.16
    Marker Score: 5,448
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.13
    Marker Score: 47,559
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.11
    Marker Score: 617
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.04
    Marker Score: 1,570
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.04
    Marker Score: 4,469
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.01
    Marker Score: 1,736
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.93
    Marker Score: 2,337
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.91
    Marker Score: 28,545
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.88
    Marker Score: 115,821
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.86
    Marker Score: 12,112
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.84
    Marker Score: 67,927
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.84
    Marker Score: 7,627
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.83
    Marker Score: 1,434
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.83
    Marker Score: 2,017
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.82
    Marker Score: 38,947
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.81
    Marker Score: 7,362
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.81
    Marker Score: 68,602
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.8
    Marker Score: 16,971
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.8
    Marker Score: 6,963
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.8
    Marker Score: 60,828
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.8
    Marker Score: 35,792
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.79
    Marker Score: 1,903
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.78
    Marker Score: 15,272
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.77
    Marker Score: 13,569
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.75
    Marker Score: 16,650
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.74
    Marker Score: 2,003
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.71
    Marker Score: 27,482
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.71
    Marker Score: 7,911
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.67
    Marker Score: 17,194
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.65
    Marker Score: 5,402
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.63
    Marker Score: 1,653
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.62
    Marker Score: 1,548
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.62
    Marker Score: 1,742
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.6
    Marker Score: 4,300
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.59
    Marker Score: 888
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.56
    Marker Score: 3,001
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.55
    Marker Score: 2,194
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.52
    Marker Score: 2,134
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.51
    Marker Score: 903
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2,287
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.43
    Marker Score: 530
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.42
    Marker Score: 1,474
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.41
    Marker Score: 3,205
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.4
    Marker Score: 1,683
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.37
    Marker Score: 434
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.37
    Marker Score: 3,280
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.37
    Marker Score: 721
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.36
    Marker Score: 2,258
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.35
    Marker Score: 13,565
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.33
    Marker Score: 774
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.31
    Marker Score: 3,096
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.31
    Marker Score: 646
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.31
    Marker Score: 7,021
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.29
    Marker Score: 8,317
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.29
    Marker Score: 908
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.28
    Marker Score: 751
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.28
    Marker Score: 538
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.28
    Marker Score: 1,546
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.27
    Marker Score: 324
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.27
    Marker Score: 1,583
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.27
    Marker Score: 1,865
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.24
    Marker Score: 463
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.24
    Marker Score: 5,334
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.21
    Marker Score: 839
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18,848
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.2
    Marker Score: 4,262
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.2
    Marker Score: 396
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.2
    Marker Score: 1,170
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.19
    Marker Score: 536
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.18
    Marker Score: 609
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.17
    Marker Score: 1,233
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.16
    Marker Score: 565
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.16
    Marker Score: 10,052
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.14
    Marker Score: 6,011
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.14
    Marker Score: 4,482
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.14
    Marker Score: 988
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.14
    Marker Score: 8,586
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.14
    Marker Score: 262
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.13
    Marker Score: 385
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1,458
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.12
    Marker Score: 2,370
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.12
    Marker Score: 417
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.12
    Marker Score: 757
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.12
    Marker Score: 1,398
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.11
    Marker Score: 2,553
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.11
    Marker Score: 303
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.1
    Marker Score: 38,142
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.09
    Marker Score: 1,570
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.08
    Marker Score: 5,833
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.08
    Marker Score: 6,412
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.08
    Marker Score: 929
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.08
    Marker Score: 406
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.08
    Marker Score: 3,702
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.08
    Marker Score: 1,218
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.07
    Marker Score: 215

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane structure:** TMEM245 is a transmembrane protein, consisting of a hydrophobic transmembrane domain and a cytoplasmic tail, which may interact with other proteins or signaling pathways. 2. **Widespread expression:** TMEM245 is significantly expressed in various epithelial cells, including those of the adrenal gland, respiratory tract, placenta, lens, kidney, and heart. 3. **Cellular localization:** TMEM245 is primarily localized to the apical or basolateral surface of epithelial cells, suggesting a role in regulating cellular interactions and signaling. **Pathways and Functions:** 1. **Cell-cell communication:** TMEM245 may play a role in facilitating cell-cell communication through interactions with other transmembrane proteins or signaling molecules. 2. **Epithelial barrier function:** TMEM245 may contribute to maintaining the integrity of epithelial barriers, such as the blood-lens barrier or the respiratory epithelium. 3. **Regulation of ion and water transport:** TMEM245 may be involved in regulating ion and water transport across epithelial cells, which is essential for maintaining proper fluid balance and electrolyte homeostasis. 4. **Signaling pathways:** TMEM245 may interact with signaling pathways, such as the PI3K/AKT or MAPK/ERK pathways, to regulate cellular processes, including proliferation, differentiation, and survival. **Clinical Significance:** 1. **Adrenal gland disorders:** Abnormal expression of TMEM245 in adrenal gland cells may contribute to disorders such as adrenal insufficiency or Cushing's syndrome. 2. **Respiratory diseases:** Altered expression of TMEM245 in respiratory epithelial cells may be linked to diseases such as chronic obstructive pulmonary disease (COPD) or asthma. 3. **Ophthalmic disorders:** TMEM245 expression in lens cells may be involved in the pathogenesis of cataracts or other lens-related disorders. 4. **Cardiac function:** TMEM245 may play a role in regulating cardiac function, particularly in the regulation of ion and water transport across cardiac myocytes. In conclusion, TMEM245 is a transmembrane protein with a complex and multifaceted role in human physiology. Further investigation into its functions and clinical significance is necessary to fully understand its implications in various diseases and disorders.

Genular Protein ID: 2455645405

Symbol: TM245_HUMAN

Name: Transmembrane protein 245

UniProtKB Accession Codes:

Q9H330 B4DSW7 Q5JTQ5 Q5SS43 Q6ZME3 Q8NDJ5 Q96CG6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10564813

Title: Cloning, genomic organization and expression of a putative human transmembrane protein related to the Caenorhabditis elegans M01F1.4 gene.

PubMed ID: 10564813

DOI: 10.1016/s0378-1119(99)00432-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 879
  • Mass: 97357
  • Checksum: AD26DE952B1D94AE
  • Sequence:
    • MADGGGPKDA PSLRSSPGPA PRVPRAVGPS GGGGETPRTA ALALRFDKPI KQAFYNTGAV 
LFVCLCCGAA VLVYFILEAF LRPLLWAVLC GTFLHPFKSS LTRLGRHWLQ RLHRAHTPIV 
LAALLLPLCF VDYGVEALGE QALRRRRLLL LLGAGGPLLY GLYCLGSYLG VQVLLVHAAT 
LICRGLDYFS SLWIWTLVVG YVLTVSFKWN ASTERYLRAV SIPVWIILLF HLASLAGSWR 
IPVFLVIVFL MSVGTLYEKQ NGKESSGAEL PGQVISMAAS TLANLAISIT GYESSSEDQP 
STQPAEAVDR GESAPTLSTS PSPSSPSPTS PSPTLGRRRP EIGTFLRKKK TSDIYFVSLV 
WAIVVMQIWL NLWIVQLLPV PIAVWILKKL VIHFGVVDFL EKRYHVWWGI IESFLKERQG 
ALAPWPIVGL GKFLLKVDSK LWHWLNKKMI IWLEKMLDKI ISIFIIFLLV IGTLLLALLL 
TAKVHQESVH MIEVTSNLIN ETLANHPEWA NWLPEAQVVQ RALNSAANNV YQYGREWITH 
KLHKILGDKV NNTAVIEKQV LELWDRLYHS WFVKNVTHSG RHKGQKLHVS RQNSWLGDIL 
DWQDIVSFVH ENIETFLSIL ESLWIVMSRN VSLLFTTVTT LLTILFYSGT ALLNFVLSLI 
IFLTTLFYLL SSSDEYYKPV KWVISLTPLS QPGPSSNIIG QSVEEAIRGV FDASLKMAGF 
YGLYTWLTHT MFGINIVFIP SALAAILGAV PFLGTYWAAV PAVLDLWLTQ GLGCKAILLL 
IFHLLPTYFV DTAIYSDISG GGHPYLTGLA VAGGAYYLGL EGAIIGPILL CILVVASNIY 
SAMLVSPTNS VPTPNQTPWP AQPQRTFRDI SEDLKSSVG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.