Details for: EID1

Gene ID: 23741

Symbol: EID1

Ensembl ID: ENSG00000255302

Description: EP300 interacting inhibitor of differentiation 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.79
    Marker Score: 50,023
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.48
    Marker Score: 4,204
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.37
    Marker Score: 6,329
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.33
    Marker Score: 3,138
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.32
    Marker Score: 21,604
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.24
    Marker Score: 4,223
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.07
    Marker Score: 18,231
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.06
    Marker Score: 4,716
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.04
    Marker Score: 4,175
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.97
    Marker Score: 7,783
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.94
    Marker Score: 3,626
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.93
    Marker Score: 2,083
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.91
    Marker Score: 2,083
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.9
    Marker Score: 8,285
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.9
    Marker Score: 1,823
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.89
    Marker Score: 28,601
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.87
    Marker Score: 5,732
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.85
    Marker Score: 4,678
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.83
    Marker Score: 32,906
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.81
    Marker Score: 20,902
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.79
    Marker Score: 2,981
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.78
    Marker Score: 5,659
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.78
    Marker Score: 1,828
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.75
    Marker Score: 31,006
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.73
    Marker Score: 5,699
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.73
    Marker Score: 11,762
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.72
    Marker Score: 3,053
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.69
    Marker Score: 1,536
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.69
    Marker Score: 927
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.69
    Marker Score: 10,401
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.67
    Marker Score: 4,873
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.65
    Marker Score: 3,680
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.64
    Marker Score: 11,017
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.64
    Marker Score: 2,482
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.64
    Marker Score: 91,355
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.63
    Marker Score: 2,815
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.63
    Marker Score: 1,561
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.62
    Marker Score: 3,795
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.62
    Marker Score: 7,017
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.61
    Marker Score: 26,292
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.6
    Marker Score: 10,633
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.6
    Marker Score: 4,414
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.59
    Marker Score: 981
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.59
    Marker Score: 6,525
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.59
    Marker Score: 2,782
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.57
    Marker Score: 6,040
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.56
    Marker Score: 143,053
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.55
    Marker Score: 609
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.54
    Marker Score: 1,842
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.54
    Marker Score: 6,920
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.52
    Marker Score: 752
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.51
    Marker Score: 10,744
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.5
    Marker Score: 1,182
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.48
    Marker Score: 7,821
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.47
    Marker Score: 2,215
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.46
    Marker Score: 789
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.46
    Marker Score: 2,372
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.45
    Marker Score: 2,487
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.44
    Marker Score: 4,134
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.44
    Marker Score: 603
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.43
    Marker Score: 2,270
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.42
    Marker Score: 2,085
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.42
    Marker Score: 24,497
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.41
    Marker Score: 542
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.4
    Marker Score: 877
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.4
    Marker Score: 830
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.4
    Marker Score: 883
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.39
    Marker Score: 2,538
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.38
    Marker Score: 1,073
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.38
    Marker Score: 1,588
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.38
    Marker Score: 9,170
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.37
    Marker Score: 20,631
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.37
    Marker Score: 2,767
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.37
    Marker Score: 3,352
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.37
    Marker Score: 1,383
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.37
    Marker Score: 2,079
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.36
    Marker Score: 2,566
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.36
    Marker Score: 80,198
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.36
    Marker Score: 1,717
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.35
    Marker Score: 5,984
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.34
    Marker Score: 1,212
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.33
    Marker Score: 2,192
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.33
    Marker Score: 1,826
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.33
    Marker Score: 14,866
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.32
    Marker Score: 1,000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.32
    Marker Score: 1,195
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.32
    Marker Score: 534
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.32
    Marker Score: 669
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.31
    Marker Score: 2,313
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.31
    Marker Score: 998
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.31
    Marker Score: 15,029
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.29
    Marker Score: 855
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.28
    Marker Score: 605
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.28
    Marker Score: 8,457
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.27
    Marker Score: 644
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.27
    Marker Score: 764
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.27
    Marker Score: 3,611
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.27
    Marker Score: 1,431
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.27
    Marker Score: 2,655
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.26
    Marker Score: 1,327

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Epithelial cell-specific expression**: EID1 is significantly expressed in epithelial cells, including mesodermal cells, glycinergic neurons, and supporting cells, highlighting its role in tissue-specific regulation. 2. **Histone acetyltransferase binding**: EID1 interacts with histone acetyltransferases (HATs), which are enzymes responsible for acetylating histones, thereby regulating chromatin structure and gene expression. 3. **Transcriptional repression**: EID1 acts as a transcriptional corepressor, inhibiting the activity of RNA polymerase II and negatively regulating DNA-templated transcription. 4. **Cell cycle regulation**: EID1 is involved in the regulation of the cell cycle, particularly in the G2/M phase transition, where it modulates the activity of cyclin-dependent kinases. **Pathways and Functions:** 1. **Histone acetylation pathway**: EID1 interacts with HATs, regulating histone acetylation and, subsequently, chromatin structure and gene expression. 2. **Transcriptional regulation**: EID1 acts as a transcriptional corepressor, inhibiting the activity of RNA polymerase II and negatively regulating DNA-templated transcription. 3. **Cell cycle regulation**: EID1 modulates the activity of cyclin-dependent kinases, influencing the G2/M phase transition and cell cycle progression. 4. **Cytoplasmic ribonucleoprotein granule pathway**: EID1 is involved in the regulation of cytoplasmic ribonucleoprotein granules, which are involved in RNA processing and translation. **Clinical Significance:** 1. **Cancer**: Dysregulation of EID1 has been implicated in various cancers, including lung, breast, and colon cancer, where it contributes to tumor progression and metastasis. 2. **Neurological disorders**: EID1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it may contribute to the regulation of gene expression and neuronal function. 3. **Autoimmune diseases**: EID1 may play a role in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it influences the regulation of immune responses and inflammation. 4. **Developmental disorders**: EID1 is involved in the regulation of embryonic development and may contribute to developmental disorders, such as Down syndrome and congenital heart defects. In conclusion, EID1 is a multifunctional gene that plays a crucial role in various cellular processes, including cell cycle regulation, differentiation, and transcriptional control. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of EID1 and its potential as a therapeutic target.

Genular Protein ID: 1193770

Symbol: EID1_HUMAN

Name: EP300-interacting inhibitor of differentiation 1

UniProtKB Accession Codes:

Q9Y6B2 B2RD11 Q8N7I4 Q9BZT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 20 Ensembl 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11073990

Title: A novel Rb- and p300-binding protein inhibits transactivation by MyoD.

PubMed ID: 11073990

DOI: 10.1128/mcb.20.23.8903-8915.2000

PubMed ID: 11223246

Title: Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein.

PubMed ID: 11223246

DOI: 10.1016/s0378-1119(00)00585-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11073989

Title: Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle.

PubMed ID: 11073989

DOI: 10.1128/mcb.20.23.8889-8902.2000

PubMed ID: 15837424

Title: Selective ablation of retinoblastoma protein function by the RET finger protein.

PubMed ID: 15837424

DOI: 10.1016/j.molcel.2005.03.009

Sequence Information:

  • Length: 187
  • Mass: 20876
  • Checksum: A2815FA78ED0736D
  • Sequence:
    • MSEMAELSEL YEESSDLQMD VMPGEGDLPQ MEVGSGSREL SLRPSRSGAQ QLEEEGPMEE 
EEAQPMAAPE GKRSLANGPN AGEQPGQVAG ADFESEDEGE EFDDWEDDYD YPEEEQLSGA 
GYRVSAALEE ADKMFLRTRE PALDGGFQMH YEKTPFDQLA FIEELFSLMV VNRLTEELGC 
DEIIDRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.