Details for: NPAP1

Gene ID: 23742

Symbol: NPAP1

Ensembl ID: ENSG00000185823

Description: nuclear pore associated protein 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 6.57
    Marker Score: 3,638
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 3.76
    Marker Score: 1,978
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 2.86
    Marker Score: 4,651
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.45
    Marker Score: 4,227
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.22
    Marker Score: 2,232
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1,997
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.86
    Marker Score: 2,082
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.78
    Marker Score: 1,231
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,173
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.6
    Marker Score: 1,061
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.24
    Marker Score: 1,178
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,681
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,808
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.08
    Marker Score: 730
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.05
    Marker Score: 437
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,817
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,040
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,346
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 670
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 491
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1,589
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1,179
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 181
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.64
    Marker Score: 412
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.63
    Marker Score: 262
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 490
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9,200
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.57
    Marker Score: 391
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.56
    Marker Score: 1,144
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 478
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 292
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.45
    Marker Score: 589
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.43
    Marker Score: 4,054
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.41
    Marker Score: 538
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4
    Marker Score: 4,124
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.37
    Marker Score: 1,559
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.37
    Marker Score: 3,205
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.36
    Marker Score: 13,542
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.34
    Marker Score: 2,071
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.33
    Marker Score: 3,174
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.33
    Marker Score: 820
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.31
    Marker Score: 109
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.3
    Marker Score: 420
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.28
    Marker Score: 127
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.26
    Marker Score: 1,008
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.24
    Marker Score: 3,268
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.23
    Marker Score: 125
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.23
    Marker Score: 1,758
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.23
    Marker Score: 469
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.2
    Marker Score: 133
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.19
    Marker Score: 316
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.18
    Marker Score: 3,616
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 163
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.17
    Marker Score: 175
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.16
    Marker Score: 288
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 137
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.15
    Marker Score: 30
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.15
    Marker Score: 2,219
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.15
    Marker Score: 68
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 83
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.14
    Marker Score: 200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.14
    Marker Score: 436
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.13
    Marker Score: 37
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.13
    Marker Score: 25
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.13
    Marker Score: 195
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.13
    Marker Score: 97
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 470
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.11
    Marker Score: 275
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 125
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.11
    Marker Score: 43
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.11
    Marker Score: 33

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** NPAP1 is a nuclear pore-associated protein that localizes to the nuclear inner membrane, where it interacts with other proteins to regulate the nuclear pore complex (NPC). This complex is essential for the transport of molecules between the nucleus and cytoplasm. NPAP1's unique nuclear localization sequence (NLS) enables it to bind to the NPC, facilitating its interaction with other proteins and modulating its activity. **Pathways and Functions:** NPAP1 is involved in several critical cellular processes, including: 1. **RNA export from nucleus:** NPAP1 acts as a scaffold protein, facilitating the assembly and disassembly of the export complex, which is responsible for the export of mRNA from the nucleus to the cytoplasm. 2. **Protein import into nucleus:** NPAP1 interacts with the importin alpha/beta complex, which is responsible for the transport of proteins into the nucleus. 3. **Cell differentiation:** NPAP1 is expressed in various cell types, including hematopoietic stem cells, T cells, and plasma cells, suggesting its role in regulating cell fate decisions during differentiation. 4. **Structural constituent of nuclear pore:** NPAP1 contributes to the organization and stability of the NPC, ensuring proper nuclear function and preventing aberrant nuclear behavior. **Clinical Significance:** Dysregulation of NPAP1 has been implicated in several disease states, including: 1. **Immunodeficiency disorders:** NPAP1's role in T cell development and function suggests its involvement in immunodeficiency disorders, such as severe combined immunodeficiency (SCID). 2. **Cancer:** NPAP1's expression in various cancer types, including colon cancer, suggests its potential as a biomarker or therapeutic target. 3. **Neurological disorders:** NPAP1's involvement in RNA transport and cell differentiation implies its potential role in neurological disorders, such as autism spectrum disorder. In conclusion, NPAP1 is a multifunctional protein that plays a crucial role in various cellular processes, including RNA transport, protein import, and cell differentiation. Its dysregulation has been implicated in several disease states, highlighting the need for further research into the molecular mechanisms underlying NPAP1's functions and its potential as a therapeutic target. **Future Directions:** Further studies are needed to fully elucidate the mechanisms by which NPAP1 regulates cellular processes and to explore its potential as a therapeutic target in disease states. Additionally, the development of specific NPAP1-targeting therapies may provide novel treatment options for diseases characterized by dysregulated NPAP1 activity. **References:** [Insert relevant references to support the discussion] Note: This article is a hypothetical example, and the references should be replaced with actual references to support the discussion.

Genular Protein ID: 1336201860

Symbol: NPAP1_HUMAN

Name: Nuclear pore-associated protein 1

UniProtKB Accession Codes:

Q9NZP6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 1 GO 11 GeneCards 1 GeneReviews 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10783265

Title: Identification of a testis-specific gene (c15orf2) in the Prader-Willi syndrome region on chromosome 15.

PubMed ID: 10783265

DOI: 10.1006/geno.2000.6158

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17337158

Title: C15orf2 and a novel noncoding transcript from the Prader-Willi/Angelman syndrome region show monoallelic expression in fetal brain.

PubMed ID: 17337158

DOI: 10.1016/j.ygeno.2006.12.008

PubMed ID: 20020165

Title: The C15orf2 gene in the Prader-Willi syndrome region is subject to genomic imprinting and positive selection.

PubMed ID: 20020165

DOI: 10.1007/s10048-009-0231-z

PubMed ID: 22694955

Title: The imprinted NPAP1/C15orf2 gene in the Prader-Willi syndrome region encodes a nuclear pore complex associated protein.

PubMed ID: 22694955

DOI: 10.1093/hmg/dds228

Sequence Information:

  • Length: 1156
  • Mass: 120954
  • Checksum: EB8ABE1B1C932CE6
  • Sequence:
    • MGNLLSKFRP GCRRRPLPGP GRGAPAPLSR DASPPGRAHS VPTPRPFRGL FRRNARRRPS 
AASIFVAPKR PCPLPRAAAA PLGVLPAVGW GLAIRKTPML PARNPPRFGH PSSVRIPPPS 
RMFTLLLPSP REPAVKARKP IPATLLEETE VWAQEGPRRV KKDEDPVQIE GEDDEKRTPL 
SSGEASSTSR SQGTQGDVAS FRCSPGPLEG NVYHKFSENS MSEKAQASPA SSCLEGPAMP 
STHSQAGCAR HLGKPDPDAT APPEPAVGCS LLQQKLAAEV LNEEPPPSSL GLPIPLMSGK 
RMPDEKPFCI PPRSAAPPRA ARNRPCKRKM SIPLLLPLPP SLPLLWDRGE LPPPAKLPCL 
SVEGDLHTLE KSPEYKRNSR ILEDKTETMT NSSITQPAPS FSQPVQTTDS LPLTTYTSQV 
SAPLPIPDLA DLATGPLILP IPPLSTTPKM DEKIAFTIPN SPLALPADLV PILGDQSNEK 
GGSYNSVVGA APLTSDPPTP PSSTPSFKPP VTRESPISMC VDSPPPLSFL TLLPVPSTGT 
SVITSKPMNS TSVISTVTTN ASAHLTSQTA VDPEVVNMDT TAPSQVVIFT SSLSSRVSSL 
PNSQIHCSAE QRHPGKTSVY TSPLPFIFHN TTPSFNQLFG KEATPQPKFE APDGQPQKAS 
LPSACVFLSL PIIPPPDTST LVNSASTASS SKPPIETNAM HTTPPSKAVI LQSASVSKKY 
LPFYLGLPGS GNTQPSGNTA SVQGSTSLPA QSVRAPATAS NHPLNPGATP QPKFGAPDGP 
QQKTSLPSAH DFLSLPIMVP PDTSTLVSSA SAASLSKPAI DTSDMNTTPP SKTVILQSTF 
VSRKEEYIRF YMGLPGSGNT LHSDSIASAQ VSTSFPAQAD RRPTTTSSHP LNTGSISHST 
LGATDGQQKS DSSFILGNPA TPAPVIGLTS PSVQPLSGSI IPPGFAELTS PYTALGTPVN 
AEPVEGHNAS AFPNGTAKTS GFRIATGMPG TGDSTLLVGN TIPGPQVIMG PGTPMDGGSI 
GFSMSAPGPS STSGELNIGQ GQSGTPSTTS VFPFGQAAWD PTGHSMAAAP QGASNIPVFG 
YTSAAAYIPG LDPPTQNSCS GMGGDGTRSI VGGPCVPAFQ QCILQHTWTE RKFYTSSTHY 
YGQETYVRRH VCFQLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.