Details for: AIPL1

Gene ID: 23746

Symbol: AIPL1

Ensembl ID: ENSG00000129221

Description: aryl hydrocarbon receptor interacting protein like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.24
    Marker Score: 12,109
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.93
    Marker Score: 874
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.76
    Marker Score: 2,076
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.78
    Marker Score: 3,377
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,172
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.57
    Marker Score: 822
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5
    Marker Score: 1,500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 856
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 488
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,818
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,054
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,288
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 391
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1,576
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.62
    Marker Score: 1,777
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.59
    Marker Score: 1,224
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.59
    Marker Score: 9,190
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.59
    Marker Score: 3,517
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 458
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 290
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.39
    Marker Score: 164
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.33
    Marker Score: 156
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.32
    Marker Score: 4,261
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.31
    Marker Score: 427
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.3
    Marker Score: 81
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.27
    Marker Score: 144
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.27
    Marker Score: 784
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.26
    Marker Score: 85
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.25
    Marker Score: 75
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.25
    Marker Score: 109
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.24
    Marker Score: 1,576
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.24
    Marker Score: 698
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.22
    Marker Score: 172
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.21
    Marker Score: 96
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.21
    Marker Score: 204
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.19
    Marker Score: 210
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.18
    Marker Score: 54
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.17
    Marker Score: 206
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 360
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.15
    Marker Score: 143
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.15
    Marker Score: 86
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.15
    Marker Score: 35
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.14
    Marker Score: 206
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.14
    Marker Score: 591
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 126
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.13
    Marker Score: 272
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.13
    Marker Score: 119
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.12
    Marker Score: 145
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 21
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.1
    Marker Score: 872
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.1
    Marker Score: 165
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1
    Marker Score: 167
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 283
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.09
    Marker Score: 114
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.09
    Marker Score: 35
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.08
    Marker Score: 57
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.08
    Marker Score: 291
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.08
    Marker Score: 1,722
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 136
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.07
    Marker Score: 166
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.07
    Marker Score: 47

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AIPL1 is a protein-coding gene, with a single copy in humans, located on chromosome 19q13.2. It shares sequence homology with the aryl hydrocarbon receptor-interacting protein (AIP), a known regulator of the aryl hydrocarbon receptor (AhR). AIPL1 is expressed in various tissues, including the retina, heart, colon, and small intestine, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** AIPL1 is implicated in several cellular pathways, including: 1. **Apoptotic process**: AIPL1 regulates apoptosis by interacting with pro-apoptotic proteins, thereby modulating the balance between cell survival and death. 2. **Protein farnesylation**: AIPL1 is involved in the farnesylation of proteins, a post-translational modification that affects protein stability, localization, and function. 3. **Photoreceptor inner segment**: AIPL1 is specifically expressed in photoreceptor cells of the retina, where it regulates the phototransduction pathway, essential for visual perception. 4. **Regulation of rhodopsin-mediated signaling**: AIPL1 interacts with rhodopsin, a key protein in the visual transduction pathway, modulating its signaling activity. **Clinical Significance:** Dysregulation of AIPL1 has been implicated in various diseases, including: 1. **Retinal degeneration**: Mutations in AIPL1 have been associated with autosomal recessive retinitis pigmentosa (arRP), a progressive eye disorder leading to blindness. 2. **Cardiac arrhythmias**: AIPL1 dysfunction has been linked to cardiac arrhythmias, such as atrial fibrillation, suggesting its role in maintaining cardiac homeostasis. 3. **Colorectal cancer**: AIPL1 expression is altered in colorectal cancer, highlighting its potential as a biomarker or therapeutic target. In conclusion, AIPL1 is a complex gene that regulates multiple cellular processes, including apoptosis, protein modification, and visual perception. Its dysregulation has been implicated in various diseases, emphasizing the need for further research into its functions and potential therapeutic applications. **Implications for Immunology:** While AIPL1 is not a traditional immunoglobulin gene, its role in regulating apoptosis and protein modification suggests its potential involvement in immune cell function and regulation. Further studies are necessary to elucidate the immunological implications of AIPL1 dysregulation and its potential as a therapeutic target in immunological diseases. **Future Directions:** Future research should focus on: 1. **Elucidating AIPL1's role in apoptosis regulation**: Investigating the molecular mechanisms by which AIPL1 modulates apoptosis will provide insights into its therapeutic potential. 2. **Exploring AIPL1's interactions with other proteins**: Investigating AIPL1's interactions with other proteins will reveal its broader functional scope and potential therapeutic applications. 3. **Developing AIPL1-based biomarkers and therapies**: Utilizing AIPL1 as a biomarker or therapeutic target will require further research into its expression patterns, cellular localization, and functional roles in disease states.

Genular Protein ID: 2254404008

Symbol: AIPL1_HUMAN

Name: Aryl-hydrocarbon-interacting protein-like 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10615133

Title: Mutations in a novel photoreceptor-pineal gene on 17p cause Leber congenital amaurosis.

PubMed ID: 10615133

DOI: 10.1038/71732

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12374762

Title: The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.

PubMed ID: 12374762

DOI: 10.1093/hmg/11.22.2723

PubMed ID: 17724218

Title: Clinical and molecular genetics of Leber's congenital amaurosis: a multicenter study of Italian patients.

PubMed ID: 17724218

DOI: 10.1167/iovs.07-0068

PubMed ID: 21602930

Title: Detection of variants in 15 genes in 87 unrelated Chinese patients with Leber congenital amaurosis.

PubMed ID: 21602930

DOI: 10.1371/journal.pone.0019458

Sequence Information:

  • Length: 384
  • Mass: 43903
  • Checksum: 47F681A1DC91A82D
  • Sequence:
  • MDAALLLNVE GVKKTILHGG TGELPNFITG SRVIFHFRTM KCDEERTVID DSRQVGQPMH 
    IIIGNMFKLE VWEILLTSMR VHEVAEFWCD TIHTGVYPIL SRSLRQMAQG KDPTEWHVHT 
    CGLANMFAYH TLGYEDLDEL QKEPQPLVFV IELLQVDAPS DYQRETWNLS NHEKMKAVPV 
    LHGEGNRLFK LGRYEEASSK YQEAIICLRN LQTKEKPWEV QWLKLEKMIN TLILNYCQCL 
    LKKEEYYEVL EHTSDILRHH PGIVKAYYVR ARAHAEVWNE AEAKADLQKV LELEPSMQKA 
    VRRELRLLEN RMAEKQEEER LRCRNMLSQG ATQPPAEPPT EPPAQSSTEP PAEPPTAPSA 
    ELSAGPPAEP ATEPPPSPGH SLQH

Genular Protein ID: 2879971421

Symbol: F1T0C4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 270
  • Mass: 31305
  • Checksum: 0319E0631C1558A4
  • Sequence:
  • MDAALLLNVE GVKKTILHGG TGELPNFITG SRVIFHFRTM KCDEERTVID DSRQVGQPMH 
    IIIGNMFKLE VWEILLTSMR VHEVAEFWCD TIHTGVYPIL SRSLRQMAQG KDPTEWHVHT 
    CGLANMFAYH TLGYEDLDEL QKEPQPLVFV IELLQVDAPS DYQRETWNLS NHEKMKAVPV 
    LHGEGNRLFK LGRYEEASSK YQEAIICLRN LQTKEKPWEV QWLKLEKMIN TLILNYCQCL 
    LKKEEYYEVL EHTSDILRHH PGARGCRGGQ

Genular Protein ID: 2364379536

Symbol: Q7Z3H1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 372
  • Mass: 42395
  • Checksum: 1F22486C830844BB
  • Sequence:
  • MDAALLLNVE GVKKTILHGG TGELPNFITG SRERTVIDDS RQVGQPMHII IGNMFKLEVW 
    EILLTSMRVH EVAEFWCDTI HTGVYPILSR SLRQMAQGKD PTEWHVHTCG LANMFAYHTL 
    GYEDLDELQK EPQPLVFVIE LLQVDAPSDY QRETWNLSNH EKMKAVPVLH GEGNRLFKLG 
    RYEEASSKYQ EAIICLRNLQ TKEKPWEVQW LKLEKMINTL ILNYCQCLLK KEEYYEVLEH 
    TSDILRHHPG IVKAYYVRAR AHAEVWNEAE AKADLQKVLE LEPSMQKAVR RELRLLENRM 
    AEKQEEERLR CRNMLSQGAT QPPAEPPTEP PAQSSTEPPA EPPTAPSAEL SAGPPAEPAT 
    EPPPSPGHSL QH

Genular Protein ID: 244706612

Symbol: F1T0C0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 345
  • Mass: 39667
  • Checksum: FDA490B5F84D39BE
  • Sequence:
  • MKCDEERTVI DDSRQVGQPM HIIIGNMFKL EVWEILLTSM RVHEVAEFWC DTIHTGVYPI 
    LSRSLRQMAQ GKDPTEWHVH TCGLANMFAY HTLGYEDLDE LQKEPQPLVF VIELLQVDAP 
    SDYQRETWNL SNHEKMKAVP VLHGEGNRLF KLGRYEEASS KYQEAIICLR NLQTKEKPWE 
    VQWLKLEKMI NTLILNYCQC LLKKEEYYEV LEHTSDILRH HPGIVKAYYV RARAHAEVWN 
    EAEAKADLQK VLELEPSMQK AVRRELRLLE NRMAEKQEEE RLRCRNMLSQ GATQPPAEPP 
    TEPPAQSSTE PPAEPPTAPS AELSAGPPAE PATEPPPSPG HSLQH

Genular Protein ID: 2884501865

Symbol: F1T0B5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 262
  • Mass: 30429
  • Checksum: 643A41E0A7A3A9FD
  • Sequence:
  • MDAALLLNVE GVKKTILHGG TGELPNFITG SRVIFHFRTM KCDEERTVID DSRQVGQPMH 
    IIIGNMFKLE VWEILLTSMR VHEVAEFWCD TIHTGVYPIL SRSLRQMAQG KDPTEWHVHT 
    CGLANMFAYH TLGYEDLDEL QKEPQPLVFV IELLQRETWN LSNHEKMKAV PVLHGEGNRL 
    FKLGRYEEAS SKYQEAIICL RNLQTKEKPW EVQWLKLEKM INTLILNYCQ CLLKKEEYYE 
    VLEHTSDILR HHPGARGCRG GQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.