Details for: YME1L1P1

Gene ID: 23749

Symbol: YME1L1P1

Ensembl ID: ENSG00000236831

Description: YME1L1 pseudogene 1

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 0

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** YME1L1P1 is a pseudogene, which means that it has undergone mutations that render it non-functional and unable to produce a protein. However, its expression in stromal cells suggests that it may still play a role in regulating cellular processes. The fact that YME1L1P1 is significantly expressed in stromal cells, a type of non-immune cell, highlights its potential involvement in tissue-specific immune responses. **Pathways and Functions:** While the YME1L1P1 gene is a pseudogene, its expression in stromal cells suggests that it may be involved in regulating cellular processes such as cell growth, differentiation, and survival. Research has shown that YME1L1, the functional homolog of YME1L1P1, is involved in the regulation of the proteasome, a protein complex responsible for degrading damaged or misfolded proteins. The proteasome plays a crucial role in maintaining protein homeostasis and preventing protein aggregation, which can contribute to various diseases, including cancer and neurodegenerative disorders. Given its expression in stromal cells, YME1L1P1 may be involved in regulating the immune response by modulating the activity of immune cells, such as T cells and dendritic cells. Additionally, YME1L1P1 may play a role in maintaining tissue homeostasis by regulating the expression of genes involved in cell growth and differentiation. **Clinical Significance:** The clinical significance of YME1L1P1 is an area of ongoing research. While its expression in stromal cells suggests that it may be involved in regulating immune responses, further studies are needed to elucidate its role in human disease. One potential area of investigation is the role of YME1L1P1 in cancer. Research has shown that the proteasome plays a crucial role in cancer progression, and dysregulation of the proteasome can contribute to tumor growth and metastasis. Given its expression in stromal cells, YME1L1P1 may be involved in regulating the immune response to cancer, and its dysregulation may contribute to cancer progression. In addition, YME1L1P1 may also play a role in autoimmune diseases, such as rheumatoid arthritis and lupus. Research has shown that dysregulation of the proteasome can contribute to autoimmune disease, and YME1L1P1 may be involved in regulating the immune response to self-antigens. In conclusion, while YME1L1P1 is a pseudogene, its expression in stromal cells suggests that it may be involved in regulating cellular processes, including the immune response. Further research is needed to elucidate its role in human disease, but its potential implications in cancer and autoimmune diseases make it an area of significant interest in the field of immunology.

Database document:

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