Details for: SDF2L1

Gene ID: 23753

Symbol: SDF2L1

Ensembl ID: ENSG00000128228

Description: stromal cell derived factor 2 like 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.43
    Marker Score: 2,925
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.5
    Marker Score: 996
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.18
    Marker Score: 753
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.09
    Marker Score: 3,001
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 2.04
    Marker Score: 889
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.99
    Marker Score: 7,662
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.98
    Marker Score: 4,501
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.95
    Marker Score: 2,357
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.8
    Marker Score: 888
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.78
    Marker Score: 492
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.75
    Marker Score: 11,135
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.72
    Marker Score: 8,241
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.7
    Marker Score: 2,736
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.69
    Marker Score: 444
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.69
    Marker Score: 1,174
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.67
    Marker Score: 3,790
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.66
    Marker Score: 4,580
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.65
    Marker Score: 576
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.65
    Marker Score: 371
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.64
    Marker Score: 686
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.61
    Marker Score: 5,944
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.59
    Marker Score: 3,883
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.58
    Marker Score: 2,623
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.58
    Marker Score: 1,516
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.58
    Marker Score: 588
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.53
    Marker Score: 9,791
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.53
    Marker Score: 870
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.51
    Marker Score: 38,709
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.51
    Marker Score: 831
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.51
    Marker Score: 3,578
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.49
    Marker Score: 2,377
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.45
    Marker Score: 14,386
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.45
    Marker Score: 916
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.44
    Marker Score: 1,052
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.43
    Marker Score: 834
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.43
    Marker Score: 49,551
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.42
    Marker Score: 4,149
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.42
    Marker Score: 1,622
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.41
    Marker Score: 5,534
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.4
    Marker Score: 2,488
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.39
    Marker Score: 1,165
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.39
    Marker Score: 509
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.39
    Marker Score: 692
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.39
    Marker Score: 1,739
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.36
    Marker Score: 337
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.36
    Marker Score: 11,737
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.36
    Marker Score: 1,511
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.33
    Marker Score: 685
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.32
    Marker Score: 686
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.31
    Marker Score: 494
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.31
    Marker Score: 649
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.31
    Marker Score: 8,544
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.31
    Marker Score: 377
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.3
    Marker Score: 11,298
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.3
    Marker Score: 292
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.3
    Marker Score: 461
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.29
    Marker Score: 328
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.29
    Marker Score: 4,045
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.28
    Marker Score: 6,746
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.27
    Marker Score: 513
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.27
    Marker Score: 1,287
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.27
    Marker Score: 43,071
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.26
    Marker Score: 1,335
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.25
    Marker Score: 836
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.24
    Marker Score: 6,094
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.24
    Marker Score: 2,611
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.23
    Marker Score: 1,814
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.23
    Marker Score: 835
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.23
    Marker Score: 5,294
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.21
    Marker Score: 565
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.21
    Marker Score: 383
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.21
    Marker Score: 3,125
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.2
    Marker Score: 1,345
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.2
    Marker Score: 4,923
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2
    Marker Score: 286
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.2
    Marker Score: 3,778
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.19
    Marker Score: 278
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.18
    Marker Score: 295
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.17
    Marker Score: 295
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.17
    Marker Score: 1,047
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.17
    Marker Score: 553
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.16
    Marker Score: 2,207
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.16
    Marker Score: 666
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.16
    Marker Score: 912
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.16
    Marker Score: 1,016
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.16
    Marker Score: 982
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.15
    Marker Score: 498
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.15
    Marker Score: 3,086
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.14
    Marker Score: 1,077
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.14
    Marker Score: 387
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.14
    Marker Score: 1,683
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.14
    Marker Score: 301
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.14
    Marker Score: 724
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.14
    Marker Score: 276
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.14
    Marker Score: 2,076
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.13
    Marker Score: 2,859
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.13
    Marker Score: 472
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.13
    Marker Score: 461
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.13
    Marker Score: 6,855
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.12
    Marker Score: 468

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SDF2L1 is a member of the HSP70 family of molecular chaperones, which are essential for maintaining protein folding and preventing protein misfolding. Its ability to bind to misfolded proteins and assist in their refolding makes it an essential component of the endoplasmic reticulum (ER) chaperone complex. SDF2L1 also interacts with other proteins involved in apoptosis, such as BCL-2 family members, modulating the regulation of apoptotic processes. **Pathways and Functions:** SDF2L1 is involved in several signaling pathways, including: 1. **Protein folding and chaperone-mediated protein refolding**: SDF2L1 binds to misfolded proteins, assisting in their refolding and preventing protein aggregation. 2. **Endoplasmic reticulum (ER) homeostasis**: SDF2L1 is a component of the ER chaperone complex, maintaining ER homeostasis and preventing ER stress. 3. **Apoptosis regulation**: SDF2L1 interacts with BCL-2 family members, modulating the regulation of apoptotic processes. 4. **Cell signaling**: SDF2L1 modulates cell signaling pathways, including those involved in immune responses, tissue homeostasis, and cellular development. **Clinical Significance:** Understanding the role of SDF2L1 in protein folding, apoptosis, and cell signaling has significant implications for various diseases, including: 1. **Immunological disorders**: Dysregulation of SDF2L1 may contribute to autoimmune diseases, such as rheumatoid arthritis, and immunodeficiency disorders, such as primary immunodeficiency diseases. 2. **Cancer**: SDF2L1 may play a role in cancer development and progression, as it can modulate cell signaling pathways involved in tumor growth and metastasis. 3. **Neurodegenerative diseases**: SDF2L1 may be involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease, where protein misfolding and aggregation are key features. 4. **Infectious diseases**: SDF2L1 may play a role in the pathogenesis of infectious diseases, such as sepsis, where ER stress and apoptosis are key mechanisms. In conclusion, SDF2L1 is a multifaceted protein that plays a crucial role in maintaining protein homeostasis, regulating apoptotic processes, and modulating cell signaling pathways. Further research is needed to fully understand its role in various diseases and to explore its potential as a therapeutic target.

Genular Protein ID: 669395550

Symbol: SDF2L_HUMAN

Name: Stromal cell-derived factor 2-like protein 1

UniProtKB Accession Codes:

Q9HCN8 A2RUD3 Q9BRI5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11162531

Title: Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family.

PubMed ID: 11162531

DOI: 10.1006/bbrc.2000.4111

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12475965

Title: A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PubMed ID: 12475965

DOI: 10.1091/mbc.e02-05-0311

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 221
  • Mass: 23598
  • Checksum: D6F15E1EB48428EE
  • Sequence:
    • MWSAGRGGAA WPVLLGLLLA LLVPGGGAAK TGAELVTCGS VLKLLNTHHR VRLHSHDIKY 
GSGSGQQSVT GVEASDDANS YWRIRGGSEG GCPRGSPVRC GQAVRLTHVL TGKNLHTHHF 
PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS GQHWEREAAV RFQHVGTSVF LSVTGEQYGS 
PIRGQHEVHG MPSANTHNTW KAMEGIFIKP SVEPSAGHDE L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.