IL17RA | ENSG00000177663 | NCBI 23765

Details for: IL17RA

Gene ID: 23765

Symbol: IL17RA

Ensembl ID: ENSG00000177663

Description: interleukin 17 receptor A

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interleukin-17 signaling
(R-HSA-448424)
Sars-cov-2 activates/modulates innate and adaptive immune responses
(R-HSA-9705671)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Signaling by interleukins
(R-HSA-449147)
Viral infection pathways
(R-HSA-9824446)
Cell surface receptor signaling pathway
(GO:0007166)
Defense response to fungus
(GO:0050832)
Extracellular region
(GO:0005576)
Fibroblast activation
(GO:0072537)
Granulocyte chemotaxis
(GO:0071621)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Interleukin-17 receptor activity
(GO:0030368)
Interleukin-17-mediated signaling pathway
(GO:0097400)
Interleukin-17a-mediated signaling pathway
(GO:0038173)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine (c-x-c motif) ligand 1 production
(GO:2000340)
Positive regulation of cytokine production involved in inflammatory response
(GO:1900017)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interleukin-5 production
(GO:0032754)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-13 production
(GO:0032736)
Positive regulation of interleukin-23 production
(GO:0032747)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Response to virus
(GO:0009615)
Signaling receptor binding
(GO:0005102)
T-helper 17 type immune response
(GO:0072538)

Other Information

Proteins

CDw217

Genular Protein ID: 2662239636

Symbol: I17RA_HUMAN

Name: CDw217

UniProtKB Accession Codes:

Q96F46 O43844 Q20WK1

Database IDs:

Citations:

PubMed ID: 9367539

Title: Molecular characterization of the human interleukin (Il)-17 receptor.

PubMed ID: 9367539

DOI: 10.1006/cyto.1997.0240

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16785495

Title: Interleukin 17 signals through a heteromeric receptor complex.

PubMed ID: 16785495

DOI: 10.4049/jimmunol.177.1.36

PubMed ID: 17911633

Title: Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F.

PubMed ID: 17911633

DOI: 10.4049/jimmunol.179.8.5462

PubMed ID: 18684971

Title: The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex.

PubMed ID: 18684971

DOI: 10.4049/jimmunol.181.4.2799

PubMed ID: 21993848

Title: IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.

PubMed ID: 21993848

DOI: 10.1038/ni.2156

PubMed ID: 24084331

Title: Identification of a soluble isoform of human IL-17RA generated by alternative splicing.

PubMed ID: 24084331

DOI: 10.1016/j.cyto.2013.09.012

PubMed ID: 24120361

Title: An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis.

PubMed ID: 24120361

DOI: 10.1016/j.immuni.2013.09.002

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32187518

Title: Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.

PubMed ID: 32187518

DOI: 10.1016/j.immuni.2020.02.004

PubMed ID: 33060197

Title: Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

PubMed ID: 33060197

DOI: 10.1126/science.abe9403

PubMed ID: 33723527

Title: Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway.

PubMed ID: 33723527

DOI: 10.1016/j.isci.2021.102293

PubMed ID: 19838198

Title: Structural basis of receptor sharing by interleukin 17 cytokines.

PubMed ID: 19838198

DOI: 10.1038/ni.1813

PubMed ID: 23695682

Title: Crystal structures of interleukin 17A and its complex with IL-17 receptor A.

PubMed ID: 23695682

DOI: 10.1038/ncomms2880

PubMed ID: 28827714

Title: The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.

PubMed ID: 28827714

DOI: 10.1038/s41598-017-08360-9

PubMed ID: 21350122

Title: Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity.

PubMed ID: 21350122

DOI: 10.1126/science.1200439

Sequence Information:

Length: 866
Mass: 96122
Checksum: 88AF626A83F3FF70
Sequence:

MGAARSPPSA VPGPLLGLLL LLLGVLAPGG ASLRLLDHRA LVCSQPGLNC TVKNSTCLDD 
SWIHPRNLTP SSPKDLQIQL HFAHTQQGDL FPVAHIEWTL QTDASILYLE GAELSVLQLN 
TNERLCVRFE FLSKLRHHHR RWRFTFSHFV VDPDQEYEVT VHHLPKPIPD GDPNHQSKNF 
LVPDCEHARM KVTTPCMSSG SLWDPNITVE TLEAHQLRVS FTLWNESTHY QILLTSFPHM 
ENHSCFEHMH HIPAPRPEEF HQRSNVTLTL RNLKGCCRHQ VQIQPFFSSC LNDCLRHSAT 
VSCPEMPDTP EPIPDYMPLW VYWFITGISI LLVGSVILLI VCMTWRLAGP GSEKYSDDTK 
YTDGLPAADL IPPPLKPRKV WIIYSADHPL YVDVVLKFAQ FLLTACGTEV ALDLLEEQAI 
SEAGVMTWVG RQKQEMVESN SKIIVLCSRG TRAKWQALLG RGAPVRLRCD HGKPVGDLFT 
AAMNMILPDF KRPACFGTYV VCYFSEVSCD GDVPDLFGAA PRYPLMDRFE EVYFRIQDLE 
MFQPGRMHRV GELSGDNYLR SPGGRQLRAA LDRFRDWQVR CPDWFECENL YSADDQDAPS 
LDEEVFEEPL LPPGTGIVKR APLVREPGSQ ACLAIDPLVG EEGGAAVAKL EPHLQPRGQP 
APQPLHTLVL AAEEGALVAA VEPGPLADGA AVRLALAGEG EACPLLGSPG AGRNSVLFLP 
VDPEDSPLGS STPMASPDLL PEDVREHLEG LMLSLFEQSL SCQAQGGCSR PAMVLTDPHT 
PYEEEQRQSV QSDQGYISRS SPQPPEGLTE MEEEEEEEQD PGKPALPLSP EDLESLRSLQ 
RQLLFRQLQK NSGWDTMGSE SEGPSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IL17RA

Associated with

Other Information

Molecular characterization of the human interleukin (Il)-17 receptor. PubMed ID: 9367539

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signal peptide prediction based on analysis of experimentally verified cleavage sites. PubMed ID: 15340161

Interleukin 17 signals through a heteromeric receptor complex. PubMed ID: 16785495

Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. PubMed ID: 17911633

The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. PubMed ID: 18684971

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. PubMed ID: 21993848

Identification of a soluble isoform of human IL-17RA generated by alternative splicing. PubMed ID: 24084331

An ACT1 mutation selectively abolishes interleukin-17 responses in humans with chronic mucocutaneous candidiasis. PubMed ID: 24120361

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling. PubMed ID: 32187518

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. PubMed ID: 33060197

Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. PubMed ID: 33723527

Structural basis of receptor sharing by interleukin 17 cytokines. PubMed ID: 19838198

Crystal structures of interleukin 17A and its complex with IL-17 receptor A. PubMed ID: 23695682

The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties. PubMed ID: 28827714

Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunity. PubMed ID: 21350122