FLRT3 | ENSG00000125848 | NCBI 23767

Details for: FLRT3

Gene ID: 23767

Symbol: FLRT3

Ensembl ID: ENSG00000125848

Description: fibronectin leucine rich transmembrane protein 3

Associated with

Developmental biology
(R-HSA-1266738)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Nervous system development
(R-HSA-9675108)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by robo receptors
(R-HSA-376176)
Signal transduction
(R-HSA-162582)
Axonal growth cone
(GO:0044295)
Axon guidance
(GO:0007411)
Axon terminus
(GO:0043679)
Cell-cell adhesion via plasma-membrane adhesion molecules
(GO:0098742)
Cell-cell junction
(GO:0005911)
Cell junction
(GO:0030054)
Chemorepellent activity
(GO:0045499)
Cytosol
(GO:0005829)
Embryonic morphogenesis
(GO:0048598)
Endoplasmic reticulum membrane
(GO:0005789)
Extracellular matrix
(GO:0031012)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Focal adhesion
(GO:0005925)
Glutamatergic synapse
(GO:0098978)
Growth cone membrane
(GO:0032584)
Head development
(GO:0060322)
Heart development
(GO:0007507)
Negative chemotaxis
(GO:0050919)
Neuron projection development
(GO:0031175)
Neuron projection extension
(GO:1990138)
Plasma membrane
(GO:0005886)
Positive regulation of synapse assembly
(GO:0051965)
Postsynaptic density
(GO:0014069)
Postsynaptic membrane
(GO:0045211)
Proepicardium cell migration involved in pericardium morphogenesis
(GO:0003345)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Response to axon injury
(GO:0048678)
Synapse assembly
(GO:0007416)
Synaptic membrane
(GO:0097060)
Synaptic membrane adhesion
(GO:0099560)

Other Information

Proteins

Leucine-rich repeat transmembrane protein FLRT3

Genular Protein ID: 736436640

Symbol: FLRT3_HUMAN

Name: Leucine-rich repeat transmembrane protein FLRT3

UniProtKB Accession Codes:

Q9NZU0 D3DW20 Q542Z9 Q96K39 Q96K42 Q96KB1 Q9P259

Database IDs:

Citations:

PubMed ID: 10644439

Title: Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins.

PubMed ID: 10644439

DOI: 10.1006/geno.1999.6033

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14706654

Title: FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth.

PubMed ID: 14706654

DOI: 10.1016/j.bbrc.2003.12.047

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26235030

Title: Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion.

PubMed ID: 26235030

DOI: 10.1016/j.str.2015.06.024

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 23643382

Title: Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism.

PubMed ID: 23643382

DOI: 10.1016/j.ajhg.2013.04.008

Sequence Information:

Length: 649
Mass: 73004
Checksum: 9EFF666C46181F08
Sequence:

MISAAWSIFL IGTKIGLFLQ VAPLSVMAKS CPSVCRCDAG FIYCNDRFLT SIPTGIPEDA 
TTLYLQNNQI NNAGIPSDLK NLLKVERIYL YHNSLDEFPT NLPKYVKELH LQENNIRTIT 
YDSLSKIPYL EELHLDDNSV SAVSIEEGAF RDSNYLRLLF LSRNHLSTIP WGLPRTIEEL 
RLDDNRISTI SSPSLQGLTS LKRLVLDGNL LNNHGLGDKV FFNLVNLTEL SLVRNSLTAA 
PVNLPGTNLR KLYLQDNHIN RVPPNAFSYL RQLYRLDMSN NNLSNLPQGI FDDLDNITQL 
ILRNNPWYCG CKMKWVRDWL QSLPVKVNVR GLMCQAPEKV RGMAIKDLNA ELFDCKDSGI 
VSTIQITTAI PNTVYPAQGQ WPAPVTKQPD IKNPKLTKDH QTTGSPSRKT ITITVKSVTS 
DTIHISWKLA LPMTALRLSW LKLGHSPAFG SITETIVTGE RSEYLVTALE PDSPYKVCMV 
PMETSNLYLF DETPVCIETE TAPLRMYNPT TTLNREQEKE PYKNPNLPLA AIIGGAVALV 
TIALLALVCW YVHRNGSLFS RNCAYSKGRR RKDDYAEAGT KKDNSILEIR ETSFQMLPIS 
NEPISKEEFV IHTIFPPNGM NLYKNNHSES SSNRSYRDSG IPDSDHSHS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FLRT3

Associated with

Other Information

Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins. PubMed ID: 10644439

Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10819331

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. PubMed ID: 16303743

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

FLRT3, a cell surface molecule containing LRR repeats and a FNIII domain, promotes neurite outgrowth. PubMed ID: 14706654

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structural basis of latrophilin-FLRT-UNC5 interaction in cell adhesion. PubMed ID: 26235030

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. PubMed ID: 21248752

Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. PubMed ID: 23643382