FKBP8 | ENSG00000105701 | NCBI 23770

Details for: FKBP8

Gene ID: 23770

Symbol: FKBP8

Ensembl ID: ENSG00000105701

Description: FKBP prolyl isomerase 8

Associated with

Deubiquitination
(R-HSA-5688426)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Ub-specific processing proteases
(R-HSA-5689880)
Apoptotic process
(GO:0006915)
Bmp signaling pathway
(GO:0030509)
Calmodulin binding
(GO:0005516)
Camera-type eye development
(GO:0043010)
Cytosol
(GO:0005829)
Disordered domain specific binding
(GO:0097718)
Dorsal/ventral neural tube patterning
(GO:0021904)
Endomembrane system
(GO:0012505)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitochondrial envelope
(GO:0005740)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Multicellular organism growth
(GO:0035264)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of protein phosphorylation
(GO:0001933)
Neuron fate specification
(GO:0048665)
Peptidyl-prolyl cis-trans isomerase activity
(GO:0003755)
Positive regulation of bmp signaling pathway
(GO:0030513)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein folding
(GO:0006457)
Protein folding chaperone
(GO:0044183)
Protein localization to mitochondrion
(GO:0070585)
Regulation of autophagy of mitochondrion
(GO:1903146)
Regulation of gene expression
(GO:0010468)
Smoothened signaling pathway
(GO:0007224)

Other Information

Proteins

Peptidyl-prolyl cis-trans isomerase FKBP8
B2R8G6_HUMAN

Genular Protein ID: 1288037272

Symbol: FKBP8_HUMAN

Name: Peptidyl-prolyl cis-trans isomerase FKBP8

UniProtKB Accession Codes:

Q14318 C8C9T5 Q53GU3 Q7Z349 Q86YK6

Database IDs:

Citations:

PubMed ID: 12510191

Title: Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.

PubMed ID: 12510191

DOI: 10.1038/ncb894

PubMed ID: 15105374

Title: FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.

PubMed ID: 15105374

DOI: 10.1242/dev.01122

PubMed ID: 18385096

Title: Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells.

PubMed ID: 18385096

DOI: 10.1167/iovs.07-1121

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 7543869

Title: Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs.

PubMed ID: 7543869

DOI: 10.1016/0378-1119(95)00216-s

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16176796

Title: Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2.

PubMed ID: 16176796

DOI: 10.1016/j.bbrc.2005.09.023

PubMed ID: 15990872

Title: Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.

PubMed ID: 15990872

DOI: 10.1038/sj.emboj.7600739

PubMed ID: 15757646

Title: A reassessment of the inhibitory capacity of human FKBP38 on calcineurin.

PubMed ID: 15757646

DOI: 10.1016/j.febslet.2004.12.098

PubMed ID: 15733859

Title: The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38).

PubMed ID: 15733859

DOI: 10.1016/j.febslet.2005.01.053

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17090549

Title: Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.

PubMed ID: 17090549

DOI: 10.1074/jbc.m606181200

PubMed ID: 16844119

Title: Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells.

PubMed ID: 16844119

DOI: 10.1016/j.febslet.2006.07.002

PubMed ID: 18459960

Title: Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse.

PubMed ID: 18459960

DOI: 10.1111/j.1365-2443.2008.01194.x

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25621951

Title: USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

PubMed ID: 25621951

DOI: 10.1038/ncb3097

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28169297

Title: Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction.

PubMed ID: 28169297

DOI: 10.1038/ncomms13876

PubMed ID: 16604427

Title: Solution structure of the FK506-binding domain of human FKBP38.

PubMed ID: 16604427

DOI: 10.1007/s10858-006-0018-6

PubMed ID: 20140889

Title: A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding.

PubMed ID: 20140889

DOI: 10.1002/jmr.1020

Sequence Information:

Length: 412
Mass: 44562
Checksum: 887C25ADE71EBA8D
Sequence:

MASCAEPSEP SAPLPAGVPP LEDFEVLDGV EDAEGEEEEE EEEEEEDDLS ELPPLEDMGQ 
PPAEEAEQPG ALAREFLAAM EPEPAPAPAP EEWLDILGNG LLRKKTLVPG PPGSSRPVKG 
QVVTVHLQTS LENGTRVQEE PELVFTLGDC DVIQALDLSV PLMDVGETAM VTADSKYCYG 
PQGRSPYIPP HAALCLEVTL KTAVDGPDLE MLTGQERVAL ANRKRECGNA HYQRADFVLA 
ANSYDLAIKA ITSSAKVDMT FEEEAQLLQL KVKCLNNLAA SQLKLDHYRA ALRSCSLVLE 
HQPDNIKALF RKGKVLAQQG EYSEAIPILR AALKLEPSNK TIHAELSKLV KKHAAQRSTE 
TALYRKMLGN PSRLPAKCPG KGAWSIPWKW LFGATAVALG GVALSVVIAA RN

Genular Protein ID: 4030448697

Symbol: B2R8G6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R8G6

Database IDs:

Sequence Information:

Length: 356
Mass: 38495
Checksum: 2457DBE1C32DB80E
Sequence:

MGQPPAEEAE QPGALAREFL AAMEPEPAPA PAPEEWLDIL GNGLLRKKTL VPGPPGSSRP 
VKGQVVTVHL QTSLENGTRV QEEPELVFTL GDCDVIQALD LSVPLMDVGE TAMVTADSKY 
CYGPQGSRSP YIPPHAALCL EVTLKTAVDG PDLEMLTGQE RVALANRKRE CGNAHYQRAD 
FVLAANSYDL AIKAITSSAK VDMTFEEEAQ LLQLKVKCLN NLAASQLKLD HYRAALRSCS 
LVLEHQPDNI KALFRKGKVL AQQGEYSEAI PILRAALKLE PSNKTIHAEL SKLVKKHAAQ 
RSTETALYRK MLGNPSRLPA KCPGKGAWSI PWKWLFGATA VALGGVALSV VIAARN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FKBP8

Associated with

Other Information

Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. PubMed ID: 12510191

FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues. PubMed ID: 15105374

Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells. PubMed ID: 18385096

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs. PubMed ID: 7543869

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2. PubMed ID: 16176796

Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin. PubMed ID: 15990872

A reassessment of the inhibitory capacity of human FKBP38 on calcineurin. PubMed ID: 15757646

The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). PubMed ID: 15733859

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression. PubMed ID: 17090549

Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells. PubMed ID: 16844119

Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse. PubMed ID: 18459960

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria. PubMed ID: 25621951

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction. PubMed ID: 28169297

Solution structure of the FK506-binding domain of human FKBP38. PubMed ID: 16604427

A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding. PubMed ID: 20140889