Genular: Defining Cellular Identity and Function

Details for: Aplnr

Gene ID: 23796

Symbol: Aplnr

Ensembl ID: ENSMUSG00000044338

Description: apelin receptor

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Adult heart development
(GO:0007512)
Angiogenesis
(GO:0001525)
Aorta development
(GO:0035904)
Apelin receptor activity
(GO:0060182)
Atrioventricular valve development
(GO:0003171)
Blood vessel development
(GO:0001568)
Coronary vasculature development
(GO:0060976)
Endocardial cushion formation
(GO:0003272)
Gastrulation
(GO:0007369)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Heart development
(GO:0007507)
Heart looping
(GO:0001947)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of camp-mediated signaling
(GO:0043951)
Negative regulation of gene expression
(GO:0010629)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903589)
Positive regulation of inhibitory g protein-coupled receptor phosphorylation
(GO:1904325)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Regulation of body fluid levels
(GO:0050878)
Regulation of gap junction assembly
(GO:1903596)
Regulation of gene expression
(GO:0010468)
Signal transduction
(GO:0007165)
Vascular associated smooth muscle cell differentiation
(GO:0035886)
Vasculature development
(GO:0001944)
Vasculogenesis
(GO:0001570)
Venous blood vessel development
(GO:0060841)
Ventricular septum morphogenesis
(GO:0060412)

Other Information

Proteins

Apelin receptor

Genular Protein ID: 317653331

Symbol: APJ_MOUSE

Name: Apelin receptor

UniProtKB Accession Codes:

Q9WV08 Q3TZS9

Database IDs:

Citations:

PubMed ID: 10473142

Title: Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ.

PubMed ID: 10473142

DOI: 10.1016/s0925-4773(99)00081-7

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 28854362

Title: Loss of Apela peptide in mice causes low penetrance embryonic lethality and defects in early mesodermal derivatives.

PubMed ID: 28854362

DOI: 10.1016/j.celrep.2017.08.014

PubMed ID: 26611206

Title: Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.

PubMed ID: 26611206

DOI: 10.1007/s00395-015-0521-6

PubMed ID: 28371822

Title: ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage.

PubMed ID: 28371822

DOI: 10.1093/cvr/cvx061

PubMed ID: 28890073

Title: Alternative progenitor cells compensate to rebuild the coronary vasculature in Elabela- and Apj-deficient hearts.

PubMed ID: 28890073

DOI: 10.1016/j.devcel.2017.08.008

PubMed ID: 28663440

Title: ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

PubMed ID: 28663440

DOI: 10.1126/science.aam6607

Sequence Information:

Length: 377
Mass: 42266
Checksum: AA443A7800A24E0B
Sequence:

MEDDGYNYYG ADNQSECDYA DWKPSGALIP AIYMLVFLLG TTGNGLVLWT VFRTSREKRR 
SADIFIASLA VADLTFVVTL PLWATYTYRE FDWPFGTFSC KLSSYLIFVN MYASVFCLTG 
LSFDRYLAIV RPVANARLRL RVSGAVATAV LWVLAALLAV PVMVFRSTDA SENGTKIQCY 
MDYSMVATSN SEWAWEVGLG VSSTAVGFVV PFTIMLTCYF FIAQTIAGHF RKERIEGLRK 
RRRLLSIIVV LVVTFALCWM PYHLVKTLYM LGSLLHWPCD FDIFLMNVFP YCTCISYVNS 
CLNPFLYAFF DPRFRQACTS MLCCDQSGCK GTPHSSSAEK SASYSSGHSQ GPGPNMGKGG 
EQMHEKSIPY SQETLVD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aplnr

Associated with

Other Information

Amino acid sequence and embryonic expression of msr/apj, the mouse homolog of Xenopus X-msr and human APJ. PubMed ID: 10473142

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Loss of Apela peptide in mice causes low penetrance embryonic lethality and defects in early mesodermal derivatives. PubMed ID: 28854362

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart. PubMed ID: 26611206

ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage. PubMed ID: 28371822

Alternative progenitor cells compensate to rebuild the coronary vasculature in Elabela- and Apj-deficient hearts. PubMed ID: 28890073

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. PubMed ID: 28663440