Genular: Defining Cellular Identity and Function

Details for: Akt3

Gene ID: 23797

Symbol: Akt3

Ensembl ID: ENSMUSG00000019699

Description: thymoma viral proto-oncogene 3

Associated with

Adaptive immune system
(R-MMU-1280218)
Akt-mediated inactivation of foxo1a
(R-MMU-211163)
Akt phosphorylates targets in the cytosol
(R-MMU-198323)
Akt phosphorylates targets in the nucleus
(R-MMU-198693)
Cd28 co-stimulation
(R-MMU-389356)
Cd28 dependent pi3k/akt signaling
(R-MMU-389357)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Costimulation by the cd28 family
(R-MMU-388841)
Ctla4 inhibitory signaling
(R-MMU-389513)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Downregulation of erbb2:erbb3 signaling
(R-MMU-1358803)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-MMU-9634638)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Flt3 signaling
(R-MMU-9607240)
Foxo-mediated transcription
(R-MMU-9614085)
G-protein beta:gamma signalling
(R-MMU-397795)
G1/s transition
(R-MMU-69206)
G beta:gamma signalling through pi3kgamma
(R-MMU-392451)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gpcr downstream signalling
(R-MMU-388396)
Immune system
(R-MMU-168256)
Intracellular signaling by second messengers
(R-MMU-9006925)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Membrane trafficking
(R-MMU-199991)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Rab gefs exchange gtp for gdp on rabs
(R-MMU-8876198)
Rab regulation of trafficking
(R-MMU-9007101)
Regulation of beta-cell development
(R-MMU-186712)
Regulation of gene expression in beta cells
(R-MMU-210745)
Regulation of localization of foxo transcription factors
(R-MMU-9614399)
Regulation of pten stability and activity
(R-MMU-8948751)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Regulation of tp53 activity through association with co-factors
(R-MMU-6804759)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by erbb2
(R-MMU-1227986)
Signaling by gpcr
(R-MMU-372790)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
S phase
(R-MMU-69242)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegfr2 mediated vascular permeability
(R-MMU-5218920)
Vesicle-mediated transport
(R-MMU-5653656)
Atp binding
(GO:0005524)
Brain morphogenesis
(GO:0048854)
Cellular response to insulin stimulus
(GO:0032869)
Cytoplasm
(GO:0005737)
Homeostasis of number of cells within a tissue
(GO:0048873)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Mitochondrial genome maintenance
(GO:0000002)
Negative regulation of cellular senescence
(GO:2000773)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of artery morphogenesis
(GO:1905653)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell migration involved in sprouting angiogenesis
(GO:0090050)
Positive regulation of cell size
(GO:0045793)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of sodium ion transport
(GO:0010765)
Positive regulation of tor signaling
(GO:0032008)
Positive regulation of vascular endothelial cell proliferation
(GO:1905564)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase c binding
(GO:0005080)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)

Other Information

Proteins

RAC-gamma serine/threonine-protein kinase
Q8C6X4_MOUSE

Genular Protein ID: 2788489029

Symbol: AKT3_MOUSE

Name: RAC-gamma serine/threonine-protein kinase

UniProtKB Accession Codes:

Q9WUA6

Database IDs:

Citations:

PubMed ID: 10092583

Title: A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain.

PubMed ID: 10092583

DOI: 10.1074/jbc.274.14.9133

PubMed ID: 11387345

Title: Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain.

PubMed ID: 11387345

DOI: 10.1074/jbc.m104633200

PubMed ID: 15713641

Title: Role for Akt3/protein kinase Bgamma in attainment of normal brain size.

PubMed ID: 15713641

DOI: 10.1128/mcb.25.5.1869-1878.2005

PubMed ID: 18160256

Title: A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB.

PubMed ID: 18160256

DOI: 10.1016/j.cellsig.2007.11.004

PubMed ID: 18524868

Title: VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase.

PubMed ID: 18524868

DOI: 10.1096/fj.08-106468

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21159799

Title: A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice.

PubMed ID: 21159799

DOI: 10.1093/hmg/ddq544

PubMed ID: 21620960

Title: Akt signalling in health and disease.

PubMed ID: 21620960

DOI: 10.1016/j.cellsig.2011.05.004

PubMed ID: 24156551

Title: KCTD20, a relative of BTBD10, is a positive regulator of Akt.

PubMed ID: 24156551

DOI: 10.1186/1471-2091-14-27

Sequence Information:

Length: 479
Mass: 55714
Checksum: F08ACDF75743B8FB
Sequence:

MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ 
LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS 
PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK 
KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE 
RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA 
ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM 
EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP 
PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDDDGMDGM DNERRPHFPQ FSYSASGRE

Genular Protein ID: 3069957058

Symbol: Q8C6X4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C6X4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 198
Mass: 22644
Checksum: 242F9CDD03C7ABE9
Sequence:

DGHIKITDFG LCKEGITDAA TMKTFCGTPE YLAPEVLEDN DYGRAVDWWG LGVVMYEMMC 
GRLPFYNQDH EKLFELILME DIKFPRTLSS DAKSLLSGLL IKDPNKRLGG GPDDAKEIMR 
HSFFSGVNWQ DVYDKKLVPP FKPQVTSETD TRYFDEEFTA QTITITPPEK YDDEGMDGMD 
NERRPHFPQF SYSASGRE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Akt3

Associated with

Other Information

A human protein kinase B gamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. PubMed ID: 10092583

Two splice variants of PKB gamma have different regulatory capacity depending on the presence or absence of the regulatory phosphorylation site Ser-472 in the C-terminal hydrophobic domain. PubMed ID: 11387345

Role for Akt3/protein kinase Bgamma in attainment of normal brain size. PubMed ID: 15713641

A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. PubMed ID: 18160256

VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase. PubMed ID: 18524868

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. PubMed ID: 21159799

Akt signalling in health and disease. PubMed ID: 21620960

KCTD20, a relative of BTBD10, is a positive regulator of Akt. PubMed ID: 24156551

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073