Details for: ALK
Associated with
Other Information
Genular Protein ID: 3021441610
Symbol: ALK_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9174053
Title: ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).
PubMed ID: 9174053
PubMed ID: 9053841
Title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.
PubMed ID: 9053841
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 8122112
Title: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
PubMed ID: 8122112
PubMed ID: 17625570
Title: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.
PubMed ID: 17625570
DOI: 10.1038/nature05945
PubMed ID: 11387242
Title: The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation.
PubMed ID: 11387242
PubMed ID: 11121404
Title: Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.
PubMed ID: 11121404
PubMed ID: 11278720
Title: Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.
PubMed ID: 11278720
PubMed ID: 12112524
Title: Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.
PubMed ID: 12112524
DOI: 10.1002/gcc.10033
PubMed ID: 11809760
Title: Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth.
PubMed ID: 11809760
PubMed ID: 12107166
Title: Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.
PubMed ID: 12107166
PubMed ID: 12122009
Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.
PubMed ID: 12122009
PubMed ID: 15226403
Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
PubMed ID: 15226403
DOI: 10.1242/jcs.01183
PubMed ID: 15938644
Title: Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity.
PubMed ID: 15938644
DOI: 10.1021/bi0472954
PubMed ID: 15908427
Title: Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.
PubMed ID: 15908427
PubMed ID: 16317043
Title: Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells.
PubMed ID: 16317043
DOI: 10.1242/jcs.02695
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 16161041
Title: Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.
PubMed ID: 16161041
DOI: 10.1002/ijc.21490
PubMed ID: 17274988
Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.
PubMed ID: 17274988
PubMed ID: 17681947
Title: Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.
PubMed ID: 17681947
PubMed ID: 16878150
Title: Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.
PubMed ID: 16878150
PubMed ID: 19459784
Title: Anaplastic lymphoma kinase: signalling in development and disease.
PubMed ID: 19459784
DOI: 10.1042/bj20090387
PubMed ID: 22327622
Title: Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.
PubMed ID: 22327622
DOI: 10.1038/nm.2673
PubMed ID: 25605972
Title: Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.
PubMed ID: 25605972
PubMed ID: 30061385
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).
PubMed ID: 30061385
PubMed ID: 33411331
Title: ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
PubMed ID: 33411331
PubMed ID: 20632993
Title: Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
PubMed ID: 20632993
DOI: 10.1042/bj20100609
PubMed ID: 20695522
Title: Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors.
PubMed ID: 20695522
DOI: 10.1021/bi1005514
PubMed ID: 20454865
Title: Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.
PubMed ID: 20454865
PubMed ID: 21575866
Title: CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
PubMed ID: 21575866
PubMed ID: 22932897
Title: The R1275Q neuroblastoma mutant and certain ATP-competitive inhibitors stabilize alternative activation loop conformations of anaplastic lymphoma kinase.
PubMed ID: 22932897
PubMed ID: 34646012
Title: Structural basis of cytokine-mediated activation of ALK family receptors.
PubMed ID: 34646012
PubMed ID: 34819673
Title: Mechanism for the activation of the anaplastic lymphoma kinase receptor.
PubMed ID: 34819673
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 18724359
Title: Identification of ALK as a major familial neuroblastoma predisposition gene.
PubMed ID: 18724359
DOI: 10.1038/nature07261
PubMed ID: 18923523
Title: Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.
PubMed ID: 18923523
DOI: 10.1038/nature07398
PubMed ID: 18923525
Title: Activating mutations in ALK provide a therapeutic target in neuroblastoma.
PubMed ID: 18923525
DOI: 10.1038/nature07397
PubMed ID: 21242967
Title: The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.
PubMed ID: 21242967
DOI: 10.1038/onc.2010.595
Sequence Information:
- Length: 1620
- Mass: 176442
- Checksum: 0733D6C4FD212F41
- Sequence:
MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP
Genular Protein ID: 2733380199
Symbol: B6D4Y2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 18923524
Title: Oncogenic mutations of ALK kinase in neuroblastoma.
PubMed ID: 18923524
DOI: 10.1038/nature07399
Sequence Information:
- Length: 1620
- Mass: 176454
- Checksum: B31ED6C4FD27284F
- Sequence:
MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL SKLRTSIIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.