Details for: ALK

Gene ID: 238

Symbol: ALK

Ensembl ID: ENSG00000171094

Description: ALK receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 7.6002
    Cell Significance Index: 108.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2650
    Cell Significance Index: -15.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.2147
    Cell Significance Index: 1511.7200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 2.5376
    Cell Significance Index: 20.4900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.4745
    Cell Significance Index: 32.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4787
    Cell Significance Index: 1022.7200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9122
    Cell Significance Index: 56.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4816
    Cell Significance Index: 11.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4592
    Cell Significance Index: 92.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.2044
    Cell Significance Index: 29.7100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1656
    Cell Significance Index: 3.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0499
    Cell Significance Index: 92.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0490
    Cell Significance Index: 92.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0399
    Cell Significance Index: 61.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0099
    Cell Significance Index: 1.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0060
    Cell Significance Index: 3.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0101
    Cell Significance Index: -0.1500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0305
    Cell Significance Index: -1.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0362
    Cell Significance Index: -16.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0373
    Cell Significance Index: -27.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0389
    Cell Significance Index: -17.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0406
    Cell Significance Index: -22.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0431
    Cell Significance Index: -31.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0443
    Cell Significance Index: -33.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0536
    Cell Significance Index: -33.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0581
    Cell Significance Index: -32.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0736
    Cell Significance Index: -13.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0836
    Cell Significance Index: -24.0600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0955
    Cell Significance Index: -2.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1222
    Cell Significance Index: -8.2200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1309
    Cell Significance Index: -1.8300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1315
    Cell Significance Index: -2.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1393
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1446
    Cell Significance Index: -24.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1488
    Cell Significance Index: -2.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1547
    Cell Significance Index: -19.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1558
    Cell Significance Index: -32.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1626
    Cell Significance Index: -12.4800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1820
    Cell Significance Index: -2.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2035
    Cell Significance Index: -27.9400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2118
    Cell Significance Index: -4.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2160
    Cell Significance Index: -27.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2204
    Cell Significance Index: -6.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2275
    Cell Significance Index: -23.6900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2525
    Cell Significance Index: -3.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2756
    Cell Significance Index: -12.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2773
    Cell Significance Index: -28.3300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2894
    Cell Significance Index: -33.1600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2950
    Cell Significance Index: -3.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3082
    Cell Significance Index: -3.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3169
    Cell Significance Index: -17.7800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3279
    Cell Significance Index: -4.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3319
    Cell Significance Index: -12.5700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3447
    Cell Significance Index: -4.3500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3486
    Cell Significance Index: -8.9600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3939
    Cell Significance Index: -6.8100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4148
    Cell Significance Index: -13.1200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4200
    Cell Significance Index: -4.9000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.4348
    Cell Significance Index: -5.2000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.4550
    Cell Significance Index: -4.7400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4669
    Cell Significance Index: -30.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4958
    Cell Significance Index: -31.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5057
    Cell Significance Index: -26.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5130
    Cell Significance Index: -10.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5180
    Cell Significance Index: -24.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5504
    Cell Significance Index: -17.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5822
    Cell Significance Index: -19.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5869
    Cell Significance Index: -20.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5956
    Cell Significance Index: -27.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6034
    Cell Significance Index: -27.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6427
    Cell Significance Index: -18.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6707
    Cell Significance Index: -17.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6922
    Cell Significance Index: -35.9600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7269
    Cell Significance Index: -6.8900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7958
    Cell Significance Index: -15.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8047
    Cell Significance Index: -28.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8179
    Cell Significance Index: -28.4200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8319
    Cell Significance Index: -20.7500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8635
    Cell Significance Index: -10.7100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8674
    Cell Significance Index: -16.9300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.8706
    Cell Significance Index: -8.7700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.9013
    Cell Significance Index: -17.7400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9056
    Cell Significance Index: -33.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9420
    Cell Significance Index: -20.1400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.9623
    Cell Significance Index: -14.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9791
    Cell Significance Index: -28.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9796
    Cell Significance Index: -28.0800
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.9854
    Cell Significance Index: -12.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9889
    Cell Significance Index: -29.1300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.0004
    Cell Significance Index: -14.7700
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.0013
    Cell Significance Index: -11.4600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0298
    Cell Significance Index: -25.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.0538
    Cell Significance Index: -30.9500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -1.0940
    Cell Significance Index: -9.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0959
    Cell Significance Index: -27.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1031
    Cell Significance Index: -23.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.1080
    Cell Significance Index: -30.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Receptor Tyrosine Kinase**: ALK is a member of the receptor tyrosine kinase family, which consists of enzymes that phosphorylate tyrosine residues on target proteins, initiating downstream signaling cascades. 2. **Autophosphorylation**: ALK exhibits intrinsic autophosphorylation activity, allowing it to activate its own kinase activity and phosphorylate downstream targets. 3. **Dimerization**: ALK can form homodimers or heterodimers with other receptor tyrosine kinases, such as MET and AURKA, to regulate its activity and signaling output. 4. **Tissue Specificity**: ALK is highly expressed in epithelial cells of the alveolus of the lung, skeletal muscle fibers, and other cell types. **Pathways and Functions** 1. **Cell Proliferation and Differentiation**: ALK signaling regulates cell proliferation, differentiation, and survival by phosphorylating and activating downstream targets, including STAT3, PI3K, and MAPK. 2. **Apoptosis**: ALK can also regulate apoptosis by phosphorylating and activating pro-apoptotic proteins, such as BAX and BAK. 3. **Metabolic Regulation**: ALK signaling is involved in regulating energy homeostasis, lipid metabolism, and glucose homeostasis. 4. **Neurodevelopment**: ALK plays a critical role in neurodevelopment, particularly in the development of GABAergic cortical interneurons. **Clinical Significance** 1. **Cancer Therapy**: Mutations in the ALK gene have been identified in various cancers, including ALCL and NSCLC. Targeted therapies, such as ALK inhibitors (e.g., crizotinib, alectinib, brigatinib), have been developed to inhibit ALK signaling and improve patient outcomes. 2. **Lung Cancer**: ALK mutations are more frequently found in NSCLC patients with a history of smoking and in patients with adenocarcinoma. 3. **Lymphoma**: ALK mutations are also found in ALCL, a type of T-cell lymphoma. 4. **Neurological Disorders**: ALK signaling has been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. In conclusion, the ALK gene plays a crucial role in regulating cellular processes, including cell proliferation, differentiation, apoptosis, and metabolic regulation. Mutations in the ALK gene have significant clinical implications, particularly in the development of targeted therapies for cancer and other diseases. Further research is needed to fully elucidate the mechanisms of ALK signaling and its role in various diseases.

Genular Protein ID: 3021441610

Symbol: ALK_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 28 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 6 OrthoDB 1 PANTHER 2 PDB 77 PDBsum 77 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 11 RefSeq 1 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9174053

Title: ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).

PubMed ID: 9174053

DOI: 10.1038/sj.onc.1201062

PubMed ID: 9053841

Title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.

PubMed ID: 9053841

DOI: 10.1038/sj.onc.1200849

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 8122112

Title: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

PubMed ID: 8122112

DOI: 10.1126/science.8122112

PubMed ID: 17625570

Title: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.

PubMed ID: 17625570

DOI: 10.1038/nature05945

PubMed ID: 11387242

Title: The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation.

PubMed ID: 11387242

DOI: 10.1096/fj.00-0678fje

PubMed ID: 11121404

Title: Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.

PubMed ID: 11121404

DOI: 10.1074/jbc.m007333200

PubMed ID: 11278720

Title: Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.

PubMed ID: 11278720

DOI: 10.1074/jbc.m010660200

PubMed ID: 12112524

Title: Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.

PubMed ID: 12112524

DOI: 10.1002/gcc.10033

PubMed ID: 11809760

Title: Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth.

PubMed ID: 11809760

DOI: 10.1074/jbc.m112354200

PubMed ID: 12107166

Title: Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.

PubMed ID: 12107166

DOI: 10.1074/jbc.m203963200

PubMed ID: 12122009

Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.

PubMed ID: 12122009

DOI: 10.1074/jbc.m205749200

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 15938644

Title: Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity.

PubMed ID: 15938644

DOI: 10.1021/bi0472954

PubMed ID: 15908427

Title: Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.

PubMed ID: 15908427

DOI: 10.1074/jbc.m502614200

PubMed ID: 16317043

Title: Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells.

PubMed ID: 16317043

DOI: 10.1242/jcs.02695

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16161041

Title: Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.

PubMed ID: 16161041

DOI: 10.1002/ijc.21490

PubMed ID: 17274988

Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

PubMed ID: 17274988

DOI: 10.1016/j.febslet.2007.01.039

PubMed ID: 17681947

Title: Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.

PubMed ID: 17681947

DOI: 10.1074/jbc.m704505200

PubMed ID: 16878150

Title: Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.

PubMed ID: 16878150

DOI: 10.1038/sj.onc.1209840

PubMed ID: 19459784

Title: Anaplastic lymphoma kinase: signalling in development and disease.

PubMed ID: 19459784

DOI: 10.1042/bj20090387

PubMed ID: 22327622

Title: Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.

PubMed ID: 22327622

DOI: 10.1038/nm.2673

PubMed ID: 25605972

Title: Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.

PubMed ID: 25605972

DOI: 10.1126/scisignal.2005916

PubMed ID: 30061385

Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).

PubMed ID: 30061385

DOI: 10.1073/pnas.1807881115

PubMed ID: 33411331

Title: ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.

PubMed ID: 33411331

DOI: 10.15252/embj.2020105784

PubMed ID: 20632993

Title: Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

PubMed ID: 20632993

DOI: 10.1042/bj20100609

PubMed ID: 20695522

Title: Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors.

PubMed ID: 20695522

DOI: 10.1021/bi1005514

PubMed ID: 20454865

Title: Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.

PubMed ID: 20454865

DOI: 10.1007/s10969-010-9091-x

PubMed ID: 21575866

Title: CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.

PubMed ID: 21575866

DOI: 10.1016/j.ccr.2011.04.004

PubMed ID: 22932897

Title: The R1275Q neuroblastoma mutant and certain ATP-competitive inhibitors stabilize alternative activation loop conformations of anaplastic lymphoma kinase.

PubMed ID: 22932897

DOI: 10.1074/jbc.m112.391425

PubMed ID: 34646012

Title: Structural basis of cytokine-mediated activation of ALK family receptors.

PubMed ID: 34646012

DOI: 10.1038/s41586-021-03959-5

PubMed ID: 34819673

Title: Mechanism for the activation of the anaplastic lymphoma kinase receptor.

PubMed ID: 34819673

DOI: 10.1038/s41586-021-04140-8

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18724359

Title: Identification of ALK as a major familial neuroblastoma predisposition gene.

PubMed ID: 18724359

DOI: 10.1038/nature07261

PubMed ID: 18923523

Title: Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.

PubMed ID: 18923523

DOI: 10.1038/nature07398

PubMed ID: 18923525

Title: Activating mutations in ALK provide a therapeutic target in neuroblastoma.

PubMed ID: 18923525

DOI: 10.1038/nature07397

PubMed ID: 21242967

Title: The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.

PubMed ID: 21242967

DOI: 10.1038/onc.2010.595

Sequence Information:

  • Length: 1620
  • Mass: 176442
  • Checksum: 0733D6C4FD212F41
  • Sequence:
    • MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 
PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 
RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 
GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 
FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ 
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 
YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 
ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC 
NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP 
APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL 
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 
NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 
KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE 
DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 
AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 
PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 
CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 
SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 
DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA 
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 
GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 
EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 
ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA 
PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS 
SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP

Genular Protein ID: 2733380199

Symbol: B6D4Y2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B6D4Y2

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 7 Gene3D 3 InterPro 12 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 3 RuleBase 1 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 18923524

Title: Oncogenic mutations of ALK kinase in neuroblastoma.

PubMed ID: 18923524

DOI: 10.1038/nature07399

Sequence Information:

  • Length: 1620
  • Mass: 176454
  • Checksum: B31ED6C4FD27284F
  • Sequence:
    • MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 
PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 
RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 
GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 
FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ 
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 
YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 
ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC 
NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP 
APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL 
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 
NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 
KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE 
DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 
AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 
PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 
CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 
SKLRTSIIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 
DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA 
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 
GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 
EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 
ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA 
PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS 
SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.