Details for: ALK

Gene ID: 238

Symbol: ALK

Ensembl ID: ENSG00000171094

Description: ALK receptor tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 4.94
    Marker Score: 2217
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.79
    Marker Score: 9493
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.79
    Marker Score: 41791
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.6
    Marker Score: 10797
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.51
    Marker Score: 4763
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.44
    Marker Score: 3432.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.34
    Marker Score: 10818
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.11
    Marker Score: 77855
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.11
    Marker Score: 8150
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.94
    Marker Score: 2419
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.79
    Marker Score: 3634
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.53
    Marker Score: 1888
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.51
    Marker Score: 32200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.51
    Marker Score: 29977
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.43
    Marker Score: 1579
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.41
    Marker Score: 1060
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.35
    Marker Score: 564
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.34
    Marker Score: 3149
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.33
    Marker Score: 878
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 799
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.28
    Marker Score: 20094
  • Cell Name: monocyte (CL0000576)
    Fold Change: 1.28
    Marker Score: 1665
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.24
    Marker Score: 5033
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.14
    Marker Score: 991
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.13
    Marker Score: 11631
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.08
    Marker Score: 603
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48012
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1
    Marker Score: 272
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.97
    Marker Score: 294
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.96
    Marker Score: 7345
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.95
    Marker Score: 330
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5342
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.91
    Marker Score: 285
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.89
    Marker Score: 231
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.88
    Marker Score: 33445
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.86
    Marker Score: 329
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.84
    Marker Score: 401
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.84
    Marker Score: 5049
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.8
    Marker Score: 352
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.78
    Marker Score: 1207
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.76
    Marker Score: 1027
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.76
    Marker Score: 384
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 692
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.75
    Marker Score: 25251
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.74
    Marker Score: 4903
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.71
    Marker Score: 2959
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.71
    Marker Score: 344
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.71
    Marker Score: 259
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.69
    Marker Score: 2905.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.68
    Marker Score: 201.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.68
    Marker Score: 380
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 446
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.67
    Marker Score: 809
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.61
    Marker Score: 1117
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.59
    Marker Score: 5090.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.59
    Marker Score: 2081
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.57
    Marker Score: 5423
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.57
    Marker Score: 980
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 234
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.56
    Marker Score: 324
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.56
    Marker Score: 34144
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.54
    Marker Score: 313
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.49
    Marker Score: 156
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.48
    Marker Score: 1380
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.47
    Marker Score: 4447
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.46
    Marker Score: 169
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.45
    Marker Score: 128
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.45
    Marker Score: 405
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.45
    Marker Score: 183
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 430
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.44
    Marker Score: 273
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.44
    Marker Score: 701.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.42
    Marker Score: 290
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.42
    Marker Score: 519
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.41
    Marker Score: 990
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.41
    Marker Score: 1185
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4
    Marker Score: 118
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.4
    Marker Score: 191
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.38
    Marker Score: 371
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.38
    Marker Score: 831
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.35
    Marker Score: 88
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.35
    Marker Score: 7864
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.35
    Marker Score: 126
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.34
    Marker Score: 967

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - ALK is a transmembrane receptor with seven extracellular repeats and a cytoplasmic juxtamembrane domain. - It is expressed in a variety of cell types, including epithelial cells of the lung, skeletal muscle fibers, and neurons. - It is typically activated by various growth factors, such as EGF, TGF-β, and PDGF. **Pathways and functions:** - ALK signaling pathway is involved in cell growth, differentiation, proliferation, and survival. - It is a key regulator of epithelial cell growth and differentiation. - It is also involved in the regulation of skeletal muscle fiber growth and metabolism. - It plays a role in the development and survival of neurons. **Clinical significance:** - ALK mutations are associated with various human cancers, including lung cancer, breast cancer, and colon cancer. - ALK inhibitors are currently being investigated as potential cancer therapies. - Inhibition of ALK signaling has been shown to inhibit cancer growth and metastasis. **Additional notes:** - ALK is a kinase that is frequently mutated in cancer. - Many ALK inhibitors are selective for mutant ALK proteins. - The development of ALK inhibitors has led to the development of new cancer treatments.

Genular Protein ID: 3021441610

Symbol: ALK_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UM73 A6P4T4 A6P4V4 Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 EMBL 8 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 99 PDBsum 77 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 11 RefSeq 1 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9174053

Title: ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK).

PubMed ID: 9174053

DOI: 10.1038/sj.onc.1201062

PubMed ID: 9053841

Title: Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system.

PubMed ID: 9053841

DOI: 10.1038/sj.onc.1200849

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 8122112

Title: Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

PubMed ID: 8122112

DOI: 10.1126/science.8122112

PubMed ID: 17625570

Title: Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer.

PubMed ID: 17625570

DOI: 10.1038/nature05945

PubMed ID: 11387242

Title: The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation.

PubMed ID: 11387242

DOI: 10.1096/fj.00-0678fje

PubMed ID: 11121404

Title: Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway.

PubMed ID: 11121404

DOI: 10.1074/jbc.m007333200

PubMed ID: 11278720

Title: Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin.

PubMed ID: 11278720

DOI: 10.1074/jbc.m010660200

PubMed ID: 12112524

Title: Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor.

PubMed ID: 12112524

DOI: 10.1002/gcc.10033

PubMed ID: 11809760

Title: Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth.

PubMed ID: 11809760

DOI: 10.1074/jbc.m112354200

PubMed ID: 12107166

Title: Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase.

PubMed ID: 12107166

DOI: 10.1074/jbc.m203963200

PubMed ID: 12122009

Title: Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types.

PubMed ID: 12122009

DOI: 10.1074/jbc.m205749200

PubMed ID: 15226403

Title: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.

PubMed ID: 15226403

DOI: 10.1242/jcs.01183

PubMed ID: 15938644

Title: Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity.

PubMed ID: 15938644

DOI: 10.1021/bi0472954

PubMed ID: 15908427

Title: Differential induction of glioblastoma migration and growth by two forms of pleiotrophin.

PubMed ID: 15908427

DOI: 10.1074/jbc.m502614200

PubMed ID: 16317043

Title: Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells.

PubMed ID: 16317043

DOI: 10.1242/jcs.02695

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16161041

Title: Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor.

PubMed ID: 16161041

DOI: 10.1002/ijc.21490

PubMed ID: 17274988

Title: ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

PubMed ID: 17274988

DOI: 10.1016/j.febslet.2007.01.039

PubMed ID: 17681947

Title: Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation.

PubMed ID: 17681947

DOI: 10.1074/jbc.m704505200

PubMed ID: 16878150

Title: Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase.

PubMed ID: 16878150

DOI: 10.1038/sj.onc.1209840

PubMed ID: 19459784

Title: Anaplastic lymphoma kinase: signalling in development and disease.

PubMed ID: 19459784

DOI: 10.1042/bj20090387

PubMed ID: 22327622

Title: Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.

PubMed ID: 22327622

DOI: 10.1038/nm.2673

PubMed ID: 25605972

Title: Heparin is an activating ligand of the orphan receptor tyrosine kinase ALK.

PubMed ID: 25605972

DOI: 10.1126/scisignal.2005916

PubMed ID: 30061385

Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-alpha).

PubMed ID: 30061385

DOI: 10.1073/pnas.1807881115

PubMed ID: 33411331

Title: ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.

PubMed ID: 33411331

DOI: 10.15252/embj.2020105784

PubMed ID: 20632993

Title: Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.

PubMed ID: 20632993

DOI: 10.1042/bj20100609

PubMed ID: 20695522

Title: Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors.

PubMed ID: 20695522

DOI: 10.1021/bi1005514

PubMed ID: 20454865

Title: Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2.

PubMed ID: 20454865

DOI: 10.1007/s10969-010-9091-x

PubMed ID: 21575866

Title: CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.

PubMed ID: 21575866

DOI: 10.1016/j.ccr.2011.04.004

PubMed ID: 22932897

Title: The R1275Q neuroblastoma mutant and certain ATP-competitive inhibitors stabilize alternative activation loop conformations of anaplastic lymphoma kinase.

PubMed ID: 22932897

DOI: 10.1074/jbc.m112.391425

PubMed ID: 34646012

Title: Structural basis of cytokine-mediated activation of ALK family receptors.

PubMed ID: 34646012

DOI: 10.1038/s41586-021-03959-5

PubMed ID: 34819673

Title: Mechanism for the activation of the anaplastic lymphoma kinase receptor.

PubMed ID: 34819673

DOI: 10.1038/s41586-021-04140-8

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18724359

Title: Identification of ALK as a major familial neuroblastoma predisposition gene.

PubMed ID: 18724359

DOI: 10.1038/nature07261

PubMed ID: 18923523

Title: Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma.

PubMed ID: 18923523

DOI: 10.1038/nature07398

PubMed ID: 18923525

Title: Activating mutations in ALK provide a therapeutic target in neuroblastoma.

PubMed ID: 18923525

DOI: 10.1038/nature07397

PubMed ID: 21242967

Title: The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.

PubMed ID: 21242967

DOI: 10.1038/onc.2010.595

Sequence Information:

  • Length: 1620
  • Mass: 176442
  • Checksum: 0733D6C4FD212F41
  • Sequence:
    • MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 
PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 
RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 
GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 
FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ 
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 
YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 
ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC 
NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP 
APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL 
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 
NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 
KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE 
DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 
AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 
PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 
CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 
SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 
DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA 
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 
GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 
EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 
ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA 
PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS 
SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP

Genular Protein ID: 2733380199

Symbol: B6D4Y2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B6D4Y2

Database IDs:

ARBA 4 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 GO 5 Gene3D 3 Genevisible 1 GenomeRNAi 1 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 3 RuleBase 1 SAM 2 SMART 2 SUPFAM 3

Citations:

PubMed ID: 18923524

Title: Oncogenic mutations of ALK kinase in neuroblastoma.

PubMed ID: 18923524

DOI: 10.1038/nature07399

Sequence Information:

  • Length: 1620
  • Mass: 176454
  • Checksum: B31ED6C4FD27284F
  • Sequence:
    • MGAIGLLWLL PLLLSTAAVG SGMGTGQRAG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 
PSLFRVYARD LLLPPSSSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPAPAEA 
RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 
GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNMPSPSPDY 
FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRIPSEEASQ 
MDLLDGPGAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 
YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 
ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQM CRKLPVGFYC 
NFEDGFCGWT QGTLSPHTPQ WQVRTLKDAR FQDHQDHALL LSTTDVPASE SATVTSATFP 
APIKSSPCEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWMVLPL 
LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 
NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 
KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDM LYILVGQQGE 
DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 
AAGGGGRAYG AKTDTFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLQEGA 
TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 
PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDPE SHKVICFCDH GTVLAEDGVS 
CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 
SKLRTSIIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSGMPN 
DPSPLQVAVK TLPEVCSEQD ELDFLMEALI ISKFNHQNIV RCIGVSLQSL PRFILLELMA 
GGDLKSFLRE TRPRPSQPSS LAMLDLLHVA RDIACGCQYL EENHFIHRDI AARNCLLTCP 
GPGRVAKIGD FGMARDIYRA SYYRKGGCAM LPVKWMPPEA FMEGIFTSKT DTWSFGVLLW 
EIFSLGYMPY PSKSNQEVLE FVTSGGRMDP PKNCPGPVYR IMTQCWQHQP EDRPNFAIIL 
ERIEYCTQDP DVINTALPIE YGPLVEEEEK VPVRPKDPEG VPPLLVSQQA KREEERSPAA 
PPPLPTTSSG KAAKKPTAAE ISVRVPRGPA VEGGHVNMAF SQSNPPSELH KVHGSRNKPT 
SLWNPTYGSW FTEKPTKKNN PIAKKEPHDR GNLGLEGSCT VPPNVATGRL PGASLLLEPS 
SLTANMKEVP LFRLRHFPCG NVNYGYQQQG LPLEAATAPG AGHYEDTILK SKNSMNQPGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.