Genular: Defining Cellular Identity and Function

Details for: Aloxe3

Gene ID: 23801

Symbol: Aloxe3

Ensembl ID: ENSMUSG00000020892

Description: arachidonate lipoxygenase 3

Associated with

Arachidonic acid metabolism
(R-MMU-2142753)
Fatty acid metabolism
(R-MMU-8978868)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-MMU-2142712)
Arachidonic acid metabolic process
(GO:0019369)
Bicellular tight junction assembly
(GO:0070830)
Catalytic activity
(GO:0003824)
Ceramide biosynthetic process
(GO:0046513)
Cytoplasm
(GO:0005737)
Dioxygenase activity
(GO:0051213)
Epidermis development
(GO:0008544)
Establishment of skin barrier
(GO:0061436)
Fat cell differentiation
(GO:0045444)
Fatty acid metabolic process
(GO:0006631)
Hepoxilin a3 synthase activity
(GO:0051120)
Hepoxilin biosynthetic process
(GO:0051122)
Hydroperoxy icosatetraenoate dehydratase activity
(GO:0106256)
Hydroperoxy icosatetraenoate isomerase activity
(GO:0106255)
Intramolecular hydroxytransferase activity
(GO:0050486)
Iron ion binding
(GO:0005506)
Isomerase activity
(GO:0016853)
Linoleic acid metabolic process
(GO:0043651)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxygenase pathway
(GO:0019372)
Lyase activity
(GO:0016829)
Metal ion binding
(GO:0046872)
Oxidoreductase activity
(GO:0016491)
Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
(GO:0016702)
Peroxisome proliferator activated receptor signaling pathway
(GO:0035357)
Sensory perception of pain
(GO:0019233)
Sphingolipid metabolic process
(GO:0006665)

Other Information

Proteins

Hydroperoxy icosatetraenoate dehydratase
Q14B96_MOUSE

Genular Protein ID: 1856252863

Symbol: LOXE3_MOUSE

Name: Hydroperoxy icosatetraenoate dehydratase

UniProtKB Accession Codes:

Q9WV07 B1ASX3

Database IDs:

Citations:

PubMed ID: 10366447

Title: cDNA cloning, genomic structure and chromosomal localization of a novel epidermis-type lipoxygenase.

PubMed ID: 10366447

DOI: 10.1006/geno.1999.5816

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 17045234

Title: Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.

PubMed ID: 17045234

DOI: 10.1016/j.abb.2006.09.002

PubMed ID: 20530198

Title: Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity.

PubMed ID: 20530198

DOI: 10.1128/mcb.01806-08

PubMed ID: 22832496

Title: Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation.

PubMed ID: 22832496

DOI: 10.1038/jid.2012.250

Sequence Information:

Length: 711
Mass: 80473
Checksum: 85A75EE2AFF3000E
Sequence:

MAVYRLCVTT GSYLKAGTLD NIYATLVGTC GESPKQKLDR VGRDFASGSV QKYKVRCEAE 
LGEILLLRLH KERFAFFCKD PWYCSRICVT APDGSAVHFP CYQWIDGYCT VELRPGTART 
ICQDSLPLLL DHRKRELQAR QECYRWKIFA PGFPRMVDVS SFQEMESDKK FALTKTVPCA 
EQDDNSGNRY LPGFPMKIDI PSLLHMEPNI RYSATKTASL IFNALPASFG MKIRGLLDRK 
GSWKRLDDIR NIFWCHKTFT SEYVTEHWCE DSFFGYQYLN GVNPVMLHCL SSLPSKLPVT 
NDMVAPLLGP GTCLQTELER GHIFLADYWI LAEAPVHCIN GLQQYVTAPL CLLWLNPQGV 
LLPLAIQLSQ TPGPESPIFL PTDCELDWLL AKTWVRNSEF LVHENNTHFL CTHLLCEAFS 
MATLRQLPLC HPVYKLLLPH TRYTLQVNTI ARATLLNPDG LVDKVTSIGR QGLIYLMSTG 
LAHFTYTDFC LPDSIRARGV LTIPNYHYRD DGLKIWAAIE RFVSEIVSYY YPSDASVQQD 
CELQAWVGEI FAQAFLGRES SGFPSRLCTP GELVKYLTAI IFNCSAQHAA VNSGQHDFGA 
WMPNAPSSMR QPPPQTKGDT TMKSYLDTLP EVNTTCRNLL LFWLVSQEPK DQRPLGTYPD 
EHFTEEAPRQ SIAAFQNCLA QISKDIRERN QSLALPYAYL DPPLIENSVS I

Genular Protein ID: 1391033912

Symbol: Q14B96_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q14B96

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 711
Mass: 80531
Checksum: 652193C7C64550E0
Sequence:

MAVYRLCVTT GSYLKAGTLD NIYATLVGTC GESPKQKLDR VGRDFASGSV QKYKVRCEAE 
LGEILLLRLH KERFAFFCKD PWYCSRICVT APDGSAVHFP CYQWIDGYCT VELRPGTART 
ICQDSLPLLL DHRKRELRAR QECYRWKIFA PGFPRMVDVS SFQEMESDKK FALTKTVPCA 
EQDDNSGNRY LPGFPMKIDI PSLLHMEPNI RYSATKTASL IFNALPASFG MKIRGLLDRK 
GSWKRLDDIR NIFWCHKTFT SEYVTEHWCE DSFFGYQYLN GVNPVMLHCL SSLPSKLPVT 
NDMVAPLLGP GTCLQTELER GHIFLADYWI LAEAPVHCIN SLQQYVTAPL CLLWLNPQGV 
LLPLAIQLSQ TPGPESPIFL PTDCELDWLL AKTWVRNSEF LVHENNTHFL CTHLLCEAFS 
MATLRQLPLC HPVYKLLLPH TRYTLQVNTI ARATLLNPDG LVDKVTSIGR QGLIYLMSTG 
LAHFTYTDFC LPDSIRARGV LTIPNYHYRD DGLKIWAAIE RFVSEIVSYY YPSDASVQQD 
CELQAWVGEI FAQAFLGRES SGFPSRLCTP GELVKYLTAI IFNCSAQHAA VNSGQHDFGA 
WMPNAPSSMR QPPPQTKGDT TMKSYLDTLP EVNTTCRNLL LFWLVSQEPK DQRPLGTYPD 
EHFTEEAPRQ SIAAFQNCLA QISKDIRERN QSLALPYAYL DPPLIENSVS I

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Aloxe3

Associated with

Other Information

cDNA cloning, genomic structure and chromosomal localization of a novel epidermis-type lipoxygenase. PubMed ID: 10366447

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. PubMed ID: 17045234

Epidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity. PubMed ID: 20530198

Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation. PubMed ID: 22832496