Genular: Defining Cellular Identity and Function

Details for: Amfr

Gene ID: 23802

Symbol: Amfr

Ensembl ID: ENSMUSG00000031751

Description: autocrine motility factor receptor

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Metabolism of proteins
(R-MMU-392499)
N-glycan trimming in the er and calnexin/calreticulin cycle
(R-MMU-532668)
Post-translational protein modification
(R-MMU-597592)
Bat3 complex binding
(GO:1904288)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Derlin-1 retrotranslocation complex
(GO:0036513)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Erad pathway
(GO:0036503)
Golgi apparatus
(GO:0005794)
Growth cone
(GO:0030426)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Neuronal cell body
(GO:0043025)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Nucleotide binding
(GO:0000166)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein-containing complex
(GO:0032991)
Protein-folding chaperone binding
(GO:0051087)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein k27-linked ubiquitination
(GO:0044314)
Protein k48-linked ubiquitination
(GO:0070936)
Protein polyubiquitination
(GO:0000209)
Regulation of srebp signaling pathway
(GO:2000638)
Signaling receptor activity
(GO:0038023)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-specific protease binding
(GO:1990381)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin binding
(GO:0043130)
Ubiquitin ligase complex
(GO:0000151)
Ubiquitin protein ligase activity
(GO:0061630)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

E3 ubiquitin-protein ligase AMFR
Q3TCI2_MOUSE

Genular Protein ID: 3871257451

Symbol: AMFR_MOUSE

Name: E3 ubiquitin-protein ligase AMFR

UniProtKB Accession Codes:

Q9R049 Q8K008 Q99LH5

Database IDs:

Citations:

PubMed ID: 10456327

Title: The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.

PubMed ID: 10456327

DOI: 10.1016/s0014-5793(99)00966-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12650607

Title: Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation.

PubMed ID: 12650607

DOI: 10.1023/a:1022594503657

PubMed ID: 16987818

Title: The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation.

PubMed ID: 16987818

DOI: 10.1074/jbc.m603355200

PubMed ID: 16709668

Title: The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor.

PubMed ID: 16709668

DOI: 10.1073/pnas.0602747103

PubMed ID: 17114649

Title: Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

PubMed ID: 17114649

DOI: 10.1074/mcp.m600046-mcp200

PubMed ID: 18216283

Title: Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508.

PubMed ID: 18216283

DOI: 10.1091/mbc.e07-06-0601

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22863805

Title: Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis.

PubMed ID: 22863805

DOI: 10.1016/j.cmet.2012.06.014

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

Sequence Information:

Length: 643
Mass: 73105
Checksum: 7119277725982F79
Sequence:

MPLLFLERFP WPSLRTYTGL SGLALLGTIV SAYRALSQPE DGSGEPEPLT APLQPEALAP 
ARLTAGGPRA RDVAQYLLSD SLFVWVLVNT ACCVLMLVAK LIQCIVFGPL RVSERQHLKD 
KFWNFIFYKF IFIFGVLNVQ TVEEVVMWCL WFAGLVFLHL MVQLCKDRFE YLSFSPTTPM 
SSHGRVLSLL IAMLLSCCGL AVVCCVTGYT HGMHTLAFMA AESLLVTVRT AHVILRYVIH 
LWDLNHEGTW EGKGTYVYYT DFVMELALLS LDLMHHIHML LFGNIWLSMA SLVIFMQLRY 
LFHEVQRRIR RHKNYLRVVG NMEARFAVAT PEELAVNNDD CAICWDSMQA ARKLPCGHLF 
HNSCLRSWLE QDTSCPTCRM SLNIADGSRA REDHQGENLD ENLVPVAAAE GRPRLNQHNH 
FFHFDGSRIA SWLPSFSVEV MHTTNILGIT QASNSQLNAM AHQIQEMFPQ VPYHLVLQDL 
QMTRSVEITT DNILEGRIQV PFPTQRSDSL RPALNSPVER PSPDLEEGEA SVQTERVPLD 
LSPRLEETLD FSEVELEPIE VEDFEARGSR FSKSADERQR MLVQRKDDLL QQARKRFLNK 
SSEDDGASER LLPSEGTSSD PVTLRRRMLA AAAERRLQRQ RTT

Genular Protein ID: 3062593662

Symbol: Q3TCI2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TCI2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 639
Mass: 72753
Checksum: 22FF6303EEA033F1
Sequence:

MPLLFLERFP WPSLRTYTGL SGLALLGTIV SAYRALSQPE DGSGEPEPLT APLQPEARLT 
AGGPRARDVA QYLLSDSLFV WVLVNTACCV LMLVAKLIQC IVFGPLRVSE RQHLKDKFWN 
FIFYKFIFIF GVLNVQTVEE VVMWCLWFAG LVFLHLMVQL CKDRFEYLSF SPTTPMSSHG 
RVLSLLIAML LSCCGLAVVC CVTGYTHGMH TLAFMAAESL LVTVRTAHVI LRYVIHLWDL 
NHEGTWEGKG TYVYYTDFVM ELALLSLDLM HHIHMLLFGN IWLSMASLVI FMQLRYLFHE 
VQRRIRRHKN YLRVVGNMEA RFAVATPEEL AVNNDDCAIC WDSMQAARKL PCGHLFHNSC 
LRSWLEQDTS CPTCRMSLNI ADGSRAREDH QGENLDENLV PVAAAEGRPR LNQHNHFFHF 
DGSRIASWLP SFSVEVMHTT NILGITQASN SQLNAMAHQI QEMFPQVPYH LVLQDLQMTR 
SVEITTDNIL EGRIQVPFPT QRSDSLRPAL NSPVERPSPD LEEGEASVQT ERVPLDLSPR 
LEETLDFSEV ELEPIEVEDF EARGSRFSKS ADERQRMLVQ RKDDLLQQAR KRFLNKSSED 
DGASERLLPS EGTSSDPVTL RRRMLAAAAE RRLQRQRTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Amfr

Associated with

Other Information

The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. PubMed ID: 10456327

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Overexpression of autocrine motility factor receptor (AMFR) in NIH3T3 fibroblasts induces cell transformation. PubMed ID: 12650607

The role of a novel p97/valosin-containing protein-interacting motif of gp78 in endoplasmic reticulum-associated degradation. PubMed ID: 16987818

The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. PubMed ID: 16709668

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. PubMed ID: 17114649

Gp78 cooperates with RMA1 in endoplasmic reticulum-associated degradation of CFTRDeltaF508. PubMed ID: 18216283

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. PubMed ID: 22863805

LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling. PubMed ID: 31073040

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073