Genular: Defining Cellular Identity and Function

Details for: Fyb1

Gene ID: 23880

Symbol: Fyb1

Ensembl ID: ENSMUSG00000022148

Description: FYN binding protein 1

Associated with

Adaptive immune system
(R-MMU-1280218)
Cell-cell communication
(R-MMU-1500931)
Generation of second messenger molecules
(R-MMU-202433)
Immune system
(R-MMU-168256)
Signal regulatory protein family interactions
(R-MMU-391160)
Tcr signaling
(R-MMU-202403)
Anchoring junction
(GO:0070161)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Integrin-mediated signaling pathway
(GO:0007229)
Lipid binding
(GO:0008289)
Mast cell activation
(GO:0045576)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to plasma membrane
(GO:0072659)
T cell receptor signaling pathway
(GO:0050852)

Other Information

Proteins

FYN-binding protein 1

Genular Protein ID: 1901781092

Symbol: FYB1_MOUSE

Name: FYN-binding protein 1

UniProtKB Accession Codes:

O35601 Q9Z2H3

Database IDs:

Citations:

PubMed ID: 9207119

Title: Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production.

PubMed ID: 9207119

DOI: 10.1073/pnas.94.14.7493

PubMed ID: 10497204

Title: Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production.

PubMed ID: 10497204

DOI: 10.1074/jbc.274.40.28427

PubMed ID: 12681493

Title: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells(1).

PubMed ID: 12681493

DOI: 10.1016/s0014-5793(03)00234-5

PubMed ID: 10469599

Title: SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages.

PubMed ID: 10469599

DOI: 10.1016/s0960-9822(99)80401-1

PubMed ID: 11207596

Title: The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages.

PubMed ID: 11207596

DOI: 10.1046/j.1462-5822.2000.00061.x

PubMed ID: 17003372

Title: ADAP is required for normal alphaIIb-beta3 activation by VWF/GP Ib-IX-V and other agonists.

PubMed ID: 17003372

DOI: 10.1182/blood-2006-05-022301

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21881001

Title: TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation.

PubMed ID: 21881001

DOI: 10.1152/ajpcell.00166.2011

Sequence Information:

Length: 819
Mass: 90055
Checksum: 6222CC7EF1CA2BBD
Sequence:

MAKFNTGSNP TEEAATSSRP FKVAGQSSPS GIQSRKNLFD NQGNASPPAG PSSMPKFGTT 
KPPLAAKPTY EEKPEKEPKP PFLKPTGGSP RFGTQPNSVS RDPEVKVGFL KPVSPKPTSL 
TKEDSKPVVL RPPGNKLHNL NQESDLKTPG PKPGPAPPVP ENELKPGFSK VAGAKSKFMP 
AAQDTDSKPR FPRHTFGQKP SLSTEDSQEE NTSKNVPVQK GSPVQLGAKS KGAPFKPPKE 
DPEDKDHGAP SSPFPGVVLK PAASRGSPGL SKNFEEKKED RKTDLAKNIF LNKLNQEEPA 
RFPKAPSKLT AGTPWGQSQE KEGDKNSATP KQKALPPLSV LGPPPPKPNR PPNVDLTRFR 
KADSANSATK SQTPYSTTSL PPPPPTHPAS QPPLPASHPA HPPVPSLPPR NIKPPLDLKH 
PINDENQDGV MHSDGTGNLE EEQESEGETY EDIDSSKERD KKREKEEKKR LELERKEQKE 
REKKEQELKK KFKLTGPIQV IHHAKACCDV KGGKNELSFK QGEDIEIIRI TDNPEGKWLG 
RTARGSYGYI KTTAVEIDYD SLKRKKNSLN AVPPRLVEDD QDVYDDVAEQ DAPNSHGQSG 
SGGMFPPPPT DDEIYDGIEE EDDDDGSVPQ VDEKTNAWSW GILKMLKGKD DRKKSIREKP 
KVSESDNNEG SSLPSQHKQL DVGEEVYDDV DASDFPPPPA EMSQGMSVGR AKTEEKDPKK 
LKKQEKEEKD LRKKFKYDGE IRVLYSTKVA SSLTSKKWGA RDLQIKPGES LEVIQSTDDT 
KVLCRNEEGK YGYVLRSYLV DNDGEIYDDI ADGCIYDND

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Fyb1

Associated with

Other Information

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. PubMed ID: 9207119

Novel isoform of lymphoid adaptor FYN-T-binding protein (FYB-130) interacts with SLP-76 and up-regulates interleukin 2 production. PubMed ID: 10497204

Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells(1). PubMed ID: 12681493

SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. PubMed ID: 10469599

The Yersinia tyrosine phosphatase YopH targets a novel adhesion-regulated signalling complex in macrophages. PubMed ID: 11207596

ADAP is required for normal alphaIIb-beta3 activation by VWF/GP Ib-IX-V and other agonists. PubMed ID: 17003372

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

TM4SF10 and ADAP interaction in podocytes: role in Fyn activity and nephrin phosphorylation. PubMed ID: 21881001