Details for: Gdf15

Gene ID: 23886

Symbol: Gdf15

Ensembl ID: ENSMUSG00000038508

Description: growth differentiation factor 15

Associated with

Other Information

Genular Protein ID: 739244871

Symbol: GDF15_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z0J7 Q6NX63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 2 GO 16 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10779363

Title: Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury.

PubMed ID: 10779363

DOI: 10.1128/mcb.20.10.3742-3751.2000

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23468844

Title: TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator.

PubMed ID: 23468844

DOI: 10.1371/journal.pone.0055174

PubMed ID: 28572090

Title: GDF15 is a heart-derived hormone that regulates body growth.

PubMed ID: 28572090

DOI: 10.15252/emmm.201707604

PubMed ID: 28953886

Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

PubMed ID: 28953886

DOI: 10.1038/nature24042

PubMed ID: 29144449

Title: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.

PubMed ID: 29144449

DOI: 10.1038/nature24481

PubMed ID: 28846097

Title: GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates.

PubMed ID: 28846097

DOI: 10.1038/nm.4392

PubMed ID: 28846099

Title: GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.

PubMed ID: 28846099

DOI: 10.1038/nm.4394

PubMed ID: 28846098

Title: The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL.

PubMed ID: 28846098

DOI: 10.1038/nm.4393

PubMed ID: 28081177

Title: First behavioral Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-beta Superfamily Cytokine, MIC-1/GDF15.

PubMed ID: 28081177

DOI: 10.1371/journal.pone.0168416

PubMed ID: 29046435

Title: Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.

PubMed ID: 29046435

DOI: 10.1126/scitranslmed.aan8732

Sequence Information:

  • Length: 303
  • Mass: 33225
  • Checksum: CD021EBEF598D3D0
  • Sequence:
    • MAPPALQAQP PGGSQLRFLL FLLLLLLLLS WPSQGDALAM PEQRPSGPES QLNADELRGR 
FQDLLSRLHA NQSREDSNSE PSPDPAVRIL SPEVRLGSHG QLLLRVNRAS LSQGLPEAYR 
VHRALLLLTP TARPWDITRP LKRALSLRGP RAPALRLRLT PPPDLAMLPS GGTQLELRLR 
VAAGRGRRSA HAHPRDSCPL GPGRCCHLET VQATLEDLGW SDWVLSPRQL QLSMCVGECP 
HLYRSANTHA QIKARLHGLQ PDKVPAPCCV PSSYTPVVLM HRTDSGVSLQ TYDDLVARGC 
HCA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.