Details for: Grem1

Gene ID: 23892

Symbol: Grem1

Ensembl ID: ENSMUSG00000074934

Description: gremlin 1, DAN family BMP antagonist

Associated with

  • Angiogenesis
    (GO:0001525)
  • Animal organ morphogenesis
    (GO:0009887)
  • Bmp binding
    (GO:0036122)
  • Cardiac muscle cell differentiation
    (GO:0055007)
  • Cardiac muscle cell myoblast differentiation
    (GO:0060379)
  • Cell-cell signaling
    (GO:0007267)
  • Cell migration involved in sprouting angiogenesis
    (GO:0002042)
  • Cell morphogenesis
    (GO:0000902)
  • Cell surface
    (GO:0009986)
  • Collagen fibril organization
    (GO:0030199)
  • Cytokine activity
    (GO:0005125)
  • Determination of dorsal identity
    (GO:0048263)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Endothelial cell migration
    (GO:0043542)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Heparan sulfate proteoglycan binding
    (GO:0043395)
  • Limb development
    (GO:0060173)
  • Mesenchymal to epithelial transition involved in metanephros morphogenesis
    (GO:0003337)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of bone mineralization
    (GO:0030502)
  • Negative regulation of bone mineralization involved in bone maturation
    (GO:1900158)
  • Negative regulation of bone remodeling
    (GO:0046851)
  • Negative regulation of bone trabecula formation
    (GO:1900155)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of cell growth
    (GO:0030308)
  • Negative regulation of chondrocyte differentiation
    (GO:0032331)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of leukocyte chemotaxis
    (GO:0002689)
  • Negative regulation of monocyte chemotaxis
    (GO:0090027)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of osteoblast proliferation
    (GO:0033689)
  • Negative regulation of osteoclast proliferation
    (GO:0090291)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of branching involved in ureteric bud morphogenesis
    (GO:0090190)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of peptidyl-tyrosine autophosphorylation
    (GO:1900086)
  • Positive regulation of protein tyrosine kinase activity
    (GO:0061098)
  • Positive regulation of receptor internalization
    (GO:0002092)
  • Positive regulation of signaling receptor activity
    (GO:2000273)
  • Positive regulation of telomerase activity
    (GO:0051973)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein homodimerization activity
    (GO:0042803)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of epithelial to mesenchymal transition
    (GO:0010717)
  • Regulation of focal adhesion assembly
    (GO:0051893)
  • Regulation of stress-activated mapk cascade
    (GO:0032872)
  • Sequestering of bmp from receptor via bmp binding
    (GO:0038098)
  • Signal transduction
    (GO:0007165)
  • Signal transduction by p53 class mediator
    (GO:0072331)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)
  • Ureteric bud formation
    (GO:0060676)
  • Vascular endothelial growth factor receptor 2 binding
    (GO:0043184)

Other Information

Genular Protein ID: 633838186

Symbol: GREM1_MOUSE

Name: Gremlin-1

UniProtKB Accession Codes:

O70326

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9660951

Title: The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities.

PubMed ID: 9660951

DOI: 10.1016/s1097-2765(00)80067-2

PubMed ID: 10965135

Title: Cloning of the murine Drm gene (Cktsf1b1) and characterization of its oncogene suppressible promoter.

PubMed ID: 10965135

DOI: 10.1159/000015625

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12808456

Title: Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning.

PubMed ID: 12808456

DOI: 10.1038/ng1178

PubMed ID: 15133038

Title: Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin.

PubMed ID: 15133038

DOI: 10.1074/jbc.m403212200

PubMed ID: 15201225

Title: Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis.

PubMed ID: 15201225

DOI: 10.1242/dev.01251

Sequence Information:

  • Length: 184
  • Mass: 20710
  • Checksum: D1BD99783CDC0F2D
  • Sequence:
    • MNRTAYTVGA LLLLLGTLLP TAEGKKKGSQ GAIPPPDKAQ HNDSEQTQSP PQPGSRTRGR 
GQGRGTAMPG EEVLESSQEA LHVTERKYLK RDWCKTQPLK QTIHEEGCNS RTIINRFCYG 
QCNSFYIPRH IRKEEGSFQS CSFCKPKKFT TMMVTLNCPE LQPPTKKKRV TRVKQCRCIS 
IDLD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.