Genular: Defining Cellular Identity and Function

Details for: Grem2

Gene ID: 23893

Symbol: Grem2

Ensembl ID: ENSMUSG00000050069

Description: gremlin 2, DAN family BMP antagonist

Associated with

Signaling by bmp
(R-MMU-201451)
Signaling by tgfb family members
(R-MMU-9006936)
Signal transduction
(R-MMU-162582)
Animal organ morphogenesis
(GO:0009887)
Bmp binding
(GO:0036122)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Determination of dorsal identity
(GO:0048263)
Embryonic body morphogenesis
(GO:0010172)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
Multicellular organism development
(GO:0007275)
Negative regulation of bmp signaling pathway
(GO:0030514)
Receptor ligand activity
(GO:0048018)
Regulation of cytokine activity
(GO:0060300)
Sequestering of bmp from receptor via bmp binding
(GO:0038098)

Other Information

Proteins

Gremlin-2

Genular Protein ID: 3266831082

Symbol: GREM2_MOUSE

Name: Gremlin-2

UniProtKB Accession Codes:

O88273

Database IDs:

Citations:

PubMed ID: 9639362

Title: Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach.

PubMed ID: 9639362

DOI: 10.1046/j.1440-169x.1998.t01-1-00010.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15039429

Title: Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation.

PubMed ID: 15039429

DOI: 10.1074/jbc.m402376200

PubMed ID: 23063586

Title: Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers.

PubMed ID: 23063586

DOI: 10.1016/j.jmb.2012.10.003

PubMed ID: 26416033

Title: GREMLIN 2 mutations and dental anomalies.

PubMed ID: 26416033

DOI: 10.1177/0022034515608168

PubMed ID: 23850456

Title: Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism.

PubMed ID: 23850456

DOI: 10.1016/j.str.2013.06.005

Sequence Information:

Length: 168
Mass: 19334
Checksum: 6361C1581D49C281
Sequence:

MFWKLSLTLL LVAVLVKVAE TRKNRPAGAI PSPYKDGSSN NSERWHHQIK EVLASSQEAL 
VVTERKYLKS DWCKTQPLRQ TVSEEGCRSR TILNRFCYGQ CNSFYIPRHV KKEEDSFQSC 
AFCKPQRVTS VIVELECPGL DPPFRIKKIQ KVKHCRCMSV NLSDSDKQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Grem2

Associated with

Other Information

Sequence and expression of a novel mouse gene PRDC (protein related to DAN and cerberus) identified by a gene trap approach. PubMed ID: 9639362

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. PubMed ID: 15039429

Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. PubMed ID: 23063586

GREMLIN 2 mutations and dental anomalies. PubMed ID: 26416033