Details for: ALOX12

Gene ID: 239

Symbol: ALOX12

Ensembl ID: ENSG00000108839

Description: arachidonate 12-lipoxygenase, 12S type

Associated with

Other Information

Genular Protein ID: 2812426038

Symbol: LOX12_HUMAN

Name: Lipoxin synthase 12-LO

UniProtKB Accession Codes:

P18054 O95569 Q6ISF8 Q9UQM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 74 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 10 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 44 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2244907

Title: Molecular cloning and expression of human arachidonate 12-lipoxygenase.

PubMed ID: 2244907

DOI: 10.1016/0006-291x(90)91580-l

PubMed ID: 2377602

Title: Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

PubMed ID: 2377602

DOI: 10.1073/pnas.87.15.5638

PubMed ID: 2217179

Title: Cloning of the cDNA for human 12-lipoxygenase.

PubMed ID: 2217179

DOI: 10.1073/pnas.87.19.7477

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1447217

Title: Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

PubMed ID: 1447217

DOI: 10.1016/s0021-9258(18)35835-6

PubMed ID: 1570320

Title: Characterization of human 12-lipoxygenase genes.

PubMed ID: 1570320

DOI: 10.1073/pnas.89.9.3962

PubMed ID: 8304420

Title: Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.

PubMed ID: 8304420

DOI: 10.1152/ajpcell.1994.266.1.c243

PubMed ID: 1851637

Title: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins.

PubMed ID: 1851637

DOI: 10.1016/0005-2760(91)90128-5

PubMed ID: 8250832

Title: Lipoxin synthase activity of human platelet 12-lipoxygenase.

PubMed ID: 8250832

DOI: 10.1042/bj2960127

PubMed ID: 8319693

Title: Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.

PubMed ID: 8319693

DOI: 10.1111/j.1432-1033.1993.tb17988.x

PubMed ID: 8500694

Title: Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies.

PubMed ID: 8500694

DOI: 10.1096/fasebj.7.8.8500694

PubMed ID: 8912711

Title: 12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.

PubMed ID: 8912711

DOI: 10.1006/excr.1996.0317

PubMed ID: 9751607

Title: Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

PubMed ID: 9751607

PubMed ID: 16638750

Title: Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.

PubMed ID: 16638750

DOI: 10.1074/jbc.m601887200

PubMed ID: 17493578

Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.

PubMed ID: 17493578

DOI: 10.1016/j.abb.2007.04.007

PubMed ID: 18311922

Title: Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.

PubMed ID: 18311922

DOI: 10.1021/bi702530z

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 22237009

Title: Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.

PubMed ID: 22237009

DOI: 10.1016/j.yexcr.2011.12.017

PubMed ID: 23578768

Title: 12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival.

PubMed ID: 23578768

DOI: 10.1016/j.yexcr.2013.04.001

PubMed ID: 22984144

Title: Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.

PubMed ID: 22984144

DOI: 10.1194/jlr.m026385

PubMed ID: 23504711

Title: The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.

PubMed ID: 23504711

DOI: 10.1096/fj.13-227728

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 25036362

Title: Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.

PubMed ID: 25036362

DOI: 10.1371/journal.pone.0102362

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

PubMed ID: 17151091

Title: Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.

PubMed ID: 17151091

DOI: 10.1093/carcin/bgl242

PubMed ID: 17460548

Title: Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.

PubMed ID: 17460548

DOI: 10.1097/fpc.0b013e328010bda1

Sequence Information:

  • Length: 663
  • Mass: 75694
  • Checksum: C4D6D5B320666A77
  • Sequence:
    • MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL 
QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA 
LDMFQKHREK ELKDRQQIYC WATWKEGLPL TIAADRKDDL PPNMRFHEEK RLDFEWTLKA 
GALEMALKRV YTLLSSWNCL EDFDQIFWGQ KSALAEKVRQ CWQDDELFSY QFLNGANPML 
LRRSTSLPSR LVLPSGMEEL QAQLEKELQN GSLFEADFIL LDGIPANVIR GEKQYLAAPL 
VMLKMEPNGK LQPMVIQIQP PNPSSPTPTL FLPSDPPLAW LLAKSWVRNS DFQLHEIQYH 
LLNTHLVAEV IAVATMRCLP GLHPIFKFLI PHIRYTMEIN TRARTQLISD GGIFDKAVST 
GGGGHVQLLR RAAAQLTYCS LCPPDDLADR GLLGLPGALY AHDALRLWEI IARYVEGIVH 
LFYQRDDIVK GDPELQAWCR EITEVGLCQA QDRGFPVSFQ SQSQLCHFLT MCVFTCTAQH 
AAINQGQLDW YAWVPNAPCT MRMPPPTTKE DVTMATVMGS LPDVRQACLQ MAISWHLSRR 
QPDMVPLGHH KEKYFSGPKP KAVLNQFRTD LEKLEKEITA RNEQLDWPYE YLKPSCIENS 
VTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.