Details for: ALOX12

Gene ID: 239

Symbol: ALOX12

Ensembl ID: ENSG00000108839

Description: arachidonate 12-lipoxygenase, 12S type

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.2590
    Cell Significance Index: -4.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.7164
    Cell Significance Index: -4.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 9.6815
    Cell Significance Index: -4.9800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.7367
    Cell Significance Index: 10.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1781
    Cell Significance Index: 35.3500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1326
    Cell Significance Index: 91.7200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1023
    Cell Significance Index: 1.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0520
    Cell Significance Index: 10.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0434
    Cell Significance Index: 0.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0416
    Cell Significance Index: 2.5600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0414
    Cell Significance Index: 0.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0273
    Cell Significance Index: 4.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0195
    Cell Significance Index: 1.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0190
    Cell Significance Index: 0.3700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0186
    Cell Significance Index: 0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0156
    Cell Significance Index: 21.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0147
    Cell Significance Index: 0.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0111
    Cell Significance Index: 3.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0097
    Cell Significance Index: 17.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0094
    Cell Significance Index: 14.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0081
    Cell Significance Index: 0.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0075
    Cell Significance Index: 3.3100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0061
    Cell Significance Index: 0.7500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0059
    Cell Significance Index: 11.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0021
    Cell Significance Index: 0.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0019
    Cell Significance Index: -0.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.4200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0054
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0056
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0062
    Cell Significance Index: -2.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0064
    Cell Significance Index: -4.7500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0066
    Cell Significance Index: -3.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0110
    Cell Significance Index: -3.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0140
    Cell Significance Index: -0.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0214
    Cell Significance Index: -1.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0226
    Cell Significance Index: -3.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0273
    Cell Significance Index: -1.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0277
    Cell Significance Index: -1.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0286
    Cell Significance Index: -3.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0315
    Cell Significance Index: -0.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0343
    Cell Significance Index: -0.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0356
    Cell Significance Index: -3.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0358
    Cell Significance Index: -2.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0381
    Cell Significance Index: -4.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0427
    Cell Significance Index: -5.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0436
    Cell Significance Index: -5.0800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0497
    Cell Significance Index: -3.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0505
    Cell Significance Index: -1.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0564
    Cell Significance Index: -1.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0584
    Cell Significance Index: -2.7300
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0605
    Cell Significance Index: -0.4400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0621
    Cell Significance Index: -2.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0659
    Cell Significance Index: -2.8700
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0683
    Cell Significance Index: -0.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0685
    Cell Significance Index: -3.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0716
    Cell Significance Index: -1.9500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0724
    Cell Significance Index: -1.2400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0772
    Cell Significance Index: -1.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0791
    Cell Significance Index: -4.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0801
    Cell Significance Index: -1.9200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0832
    Cell Significance Index: -1.1100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0853
    Cell Significance Index: -2.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0863
    Cell Significance Index: -3.9100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0912
    Cell Significance Index: -1.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0920
    Cell Significance Index: -2.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0953
    Cell Significance Index: -3.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0955
    Cell Significance Index: -2.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0990
    Cell Significance Index: -3.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1013
    Cell Significance Index: -2.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1145
    Cell Significance Index: -1.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1152
    Cell Significance Index: -2.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1266
    Cell Significance Index: -4.4500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1268
    Cell Significance Index: -4.0100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1275
    Cell Significance Index: -1.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1362
    Cell Significance Index: -2.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1364
    Cell Significance Index: -4.7400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1364
    Cell Significance Index: -1.9400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1391
    Cell Significance Index: -3.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1427
    Cell Significance Index: -2.4600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1442
    Cell Significance Index: -1.8200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1461
    Cell Significance Index: -3.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1493
    Cell Significance Index: -6.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1535
    Cell Significance Index: -4.5200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1547
    Cell Significance Index: -3.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1566
    Cell Significance Index: -4.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1569
    Cell Significance Index: -3.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1571
    Cell Significance Index: -2.3200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1586
    Cell Significance Index: -4.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1591
    Cell Significance Index: -4.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1604
    Cell Significance Index: -1.5200
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1632
    Cell Significance Index: -2.3700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1666
    Cell Significance Index: -3.3000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1672
    Cell Significance Index: -1.9700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1675
    Cell Significance Index: -3.5000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1687
    Cell Significance Index: -1.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1689
    Cell Significance Index: -4.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1693
    Cell Significance Index: -1.8400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1700
    Cell Significance Index: -3.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALOX12 is a member of the lipoxygenase family, which catalyzes the oxidation of polyunsaturated fatty acids to form hydroperoxides. The 12S type of ALOX12 is specifically involved in the metabolism of arachidonic acid, producing 12-eicosatetraenoic acid (12-ETE) and other 12-LO derivatives. ALOX12 is predominantly expressed in cells of the immune system, including megakaryocytes, erythrocytes, and epithelial cells of the kidney and retina. **Pathways and Functions:** The ALOX12 enzyme is involved in several critical pathways, including: 1. **Arachidonic acid metabolic process**: ALOX12 converts arachidonic acid into 12-ETE, which is further metabolized to form lipoxins, hepoxilins, and trioxilins. 2. **Lipid metabolic process**: ALOX12 is responsible for the oxidation of polyunsaturated fatty acids, leading to the production of hydroperoxides and other lipid derivatives. 3. **Immune regulation**: Lipoxins, hepoxilins, and trioxilins produced by ALOX12 have anti-inflammatory properties and are involved in the regulation of immune responses, including the suppression of leukotriene B4 production and platelet aggregation. **Clinical Significance:** Dysregulation of ALOX12 has been implicated in various diseases, including: 1. **Inflammatory disorders**: ALOX12 has been shown to play a role in the pathogenesis of inflammatory conditions, such as arthritis, asthma, and allergies. 2. **Cancer**: Alterations in ALOX12 expression have been observed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: ALOX12 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, ALOX12 is a critical enzyme involved in the metabolism of arachidonic acid and the biosynthesis of bioactive lipid mediators. Its dysregulation has been implicated in various diseases, highlighting the importance of ALOX12 in maintaining immune homeostasis and cellular balance. Further research is needed to fully elucidate the functional significance of ALOX12 and its role in human disease.

Genular Protein ID: 2812426038

Symbol: LOX12_HUMAN

Name: Lipoxin synthase 12-LO

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2244907

Title: Molecular cloning and expression of human arachidonate 12-lipoxygenase.

PubMed ID: 2244907

DOI: 10.1016/0006-291x(90)91580-l

PubMed ID: 2377602

Title: Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

PubMed ID: 2377602

DOI: 10.1073/pnas.87.15.5638

PubMed ID: 2217179

Title: Cloning of the cDNA for human 12-lipoxygenase.

PubMed ID: 2217179

DOI: 10.1073/pnas.87.19.7477

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1447217

Title: Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

PubMed ID: 1447217

DOI: 10.1016/s0021-9258(18)35835-6

PubMed ID: 1570320

Title: Characterization of human 12-lipoxygenase genes.

PubMed ID: 1570320

DOI: 10.1073/pnas.89.9.3962

PubMed ID: 8304420

Title: Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.

PubMed ID: 8304420

DOI: 10.1152/ajpcell.1994.266.1.c243

PubMed ID: 1851637

Title: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins.

PubMed ID: 1851637

DOI: 10.1016/0005-2760(91)90128-5

PubMed ID: 8250832

Title: Lipoxin synthase activity of human platelet 12-lipoxygenase.

PubMed ID: 8250832

DOI: 10.1042/bj2960127

PubMed ID: 8319693

Title: Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.

PubMed ID: 8319693

DOI: 10.1111/j.1432-1033.1993.tb17988.x

PubMed ID: 8500694

Title: Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies.

PubMed ID: 8500694

DOI: 10.1096/fasebj.7.8.8500694

PubMed ID: 8912711

Title: 12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.

PubMed ID: 8912711

DOI: 10.1006/excr.1996.0317

PubMed ID: 9751607

Title: Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

PubMed ID: 9751607

PubMed ID: 16638750

Title: Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.

PubMed ID: 16638750

DOI: 10.1074/jbc.m601887200

PubMed ID: 17493578

Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.

PubMed ID: 17493578

DOI: 10.1016/j.abb.2007.04.007

PubMed ID: 18311922

Title: Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.

PubMed ID: 18311922

DOI: 10.1021/bi702530z

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 22237009

Title: Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.

PubMed ID: 22237009

DOI: 10.1016/j.yexcr.2011.12.017

PubMed ID: 23578768

Title: 12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival.

PubMed ID: 23578768

DOI: 10.1016/j.yexcr.2013.04.001

PubMed ID: 22984144

Title: Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.

PubMed ID: 22984144

DOI: 10.1194/jlr.m026385

PubMed ID: 23504711

Title: The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.

PubMed ID: 23504711

DOI: 10.1096/fj.13-227728

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 25036362

Title: Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.

PubMed ID: 25036362

DOI: 10.1371/journal.pone.0102362

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

PubMed ID: 17151091

Title: Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.

PubMed ID: 17151091

DOI: 10.1093/carcin/bgl242

PubMed ID: 17460548

Title: Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.

PubMed ID: 17460548

DOI: 10.1097/fpc.0b013e328010bda1

Sequence Information:

  • Length: 663
  • Mass: 75694
  • Checksum: C4D6D5B320666A77
  • Sequence:
  • MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL 
    QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA 
    LDMFQKHREK ELKDRQQIYC WATWKEGLPL TIAADRKDDL PPNMRFHEEK RLDFEWTLKA 
    GALEMALKRV YTLLSSWNCL EDFDQIFWGQ KSALAEKVRQ CWQDDELFSY QFLNGANPML 
    LRRSTSLPSR LVLPSGMEEL QAQLEKELQN GSLFEADFIL LDGIPANVIR GEKQYLAAPL 
    VMLKMEPNGK LQPMVIQIQP PNPSSPTPTL FLPSDPPLAW LLAKSWVRNS DFQLHEIQYH 
    LLNTHLVAEV IAVATMRCLP GLHPIFKFLI PHIRYTMEIN TRARTQLISD GGIFDKAVST 
    GGGGHVQLLR RAAAQLTYCS LCPPDDLADR GLLGLPGALY AHDALRLWEI IARYVEGIVH 
    LFYQRDDIVK GDPELQAWCR EITEVGLCQA QDRGFPVSFQ SQSQLCHFLT MCVFTCTAQH 
    AAINQGQLDW YAWVPNAPCT MRMPPPTTKE DVTMATVMGS LPDVRQACLQ MAISWHLSRR 
    QPDMVPLGHH KEKYFSGPKP KAVLNQFRTD LEKLEKEITA RNEQLDWPYE YLKPSCIENS 
    VTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.