Details for: ALOX12

Gene ID: 239

Symbol: ALOX12

Ensembl ID: ENSG00000108839

Description: arachidonate 12-lipoxygenase, 12S type

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 10.73
    Marker Score: 34368
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.81
    Marker Score: 19851
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.91
    Marker Score: 17526
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.51
    Marker Score: 4322
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 4.11
    Marker Score: 34729
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.85
    Marker Score: 11051
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.41
    Marker Score: 9731
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.67
    Marker Score: 697
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.42
    Marker Score: 2935
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.02
    Marker Score: 6748
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5340
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.79
    Marker Score: 1044
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 424
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6
    Marker Score: 1146
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 474
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.57
    Marker Score: 4922
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.52
    Marker Score: 4057
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.5
    Marker Score: 317
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5
    Marker Score: 291
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 405
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.41
    Marker Score: 202
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 102
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.38
    Marker Score: 321
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 118.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.35
    Marker Score: 569
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.35
    Marker Score: 706
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5371
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.31
    Marker Score: 737
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.3
    Marker Score: 123
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.26
    Marker Score: 132
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.26
    Marker Score: 1560
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.25
    Marker Score: 105
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.25
    Marker Score: 192
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 138
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.24
    Marker Score: 109
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.23
    Marker Score: 291
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.22
    Marker Score: 107
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.22
    Marker Score: 199
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.22
    Marker Score: 298
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.22
    Marker Score: 105
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.21
    Marker Score: 369
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2
    Marker Score: 243
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.17
    Marker Score: 256
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.16
    Marker Score: 663.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.15
    Marker Score: 41
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 102
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 78
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.14
    Marker Score: 39
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.14
    Marker Score: 2957
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.12
    Marker Score: 108
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.12
    Marker Score: 85
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 136
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.12
    Marker Score: 89
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.11
    Marker Score: 275
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 105
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.11
    Marker Score: 74
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 888
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 185
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.1
    Marker Score: 410
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1
    Marker Score: 213
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.1
    Marker Score: 39
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.09
    Marker Score: 71
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.09
    Marker Score: 892
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.09
    Marker Score: 243
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 31.5
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.09
    Marker Score: 18
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.09
    Marker Score: 5385

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Other Information

**Key characteristics:** - The protein is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is localized to the endoplasmic reticulum. - It is a homotrimer, meaning that it consists of four identical subunits that are held together by disulfide bonds. **Pathways and functions:** The ALOX12 gene is involved in a variety of pathways, including: - Arachidonate 12(s)-lipoxygenase activity: The protein is involved in the biosynthesis of 12-eicosatetraenoic acid derivatives, which are important mediators of inflammation and pain. - Arachidonic acid metabolism: The protein is involved in the metabolism of arachidonic acid and related compounds, including the synthesis of hepoxilins and trioxilins. - Biosynthesis of spms: The protein is involved in the biosynthesis of specialized proresolving mediators (spms), which are involved in the resolution of inflammation. - Fatty acid metabolism: The protein is involved in the metabolism of fatty acids, including the synthesis of 12-eicosatetraenoic acid derivatives. - Hepoxilin-epoxide hydrolase activity: The protein is involved in the metabolism of hepoxilins and trioxilins, which are involved in the detoxification of reactive oxygen species. - Iron ion binding: The protein is involved in the binding of iron ions, which is essential for its activity. **Clinical significance:** Mutations in the ALOX12 gene have been linked to a number of human diseases, including atherosclerosis, rheumatoid arthritis, and inflammatory bowel disease. These diseases are characterized by the accumulation of a variety of lipid mediators in the blood, which can lead to inflammation and damage to tissues. The ALOX12 gene is a promising target for the treatment of these diseases.

Genular Protein ID: 2812426038

Symbol: LOX12_HUMAN

Name: Lipoxin synthase 12-LO

UniProtKB Accession Codes:

P18054 O95569 Q6ISF8 Q9UQM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 74 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 10 EMDB 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 25 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 5 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 44 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2244907

Title: Molecular cloning and expression of human arachidonate 12-lipoxygenase.

PubMed ID: 2244907

DOI: 10.1016/0006-291x(90)91580-l

PubMed ID: 2377602

Title: Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

PubMed ID: 2377602

DOI: 10.1073/pnas.87.15.5638

PubMed ID: 2217179

Title: Cloning of the cDNA for human 12-lipoxygenase.

PubMed ID: 2217179

DOI: 10.1073/pnas.87.19.7477

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1447217

Title: Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

PubMed ID: 1447217

DOI: 10.1016/s0021-9258(18)35835-6

PubMed ID: 1570320

Title: Characterization of human 12-lipoxygenase genes.

PubMed ID: 1570320

DOI: 10.1073/pnas.89.9.3962

PubMed ID: 8304420

Title: Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.

PubMed ID: 8304420

DOI: 10.1152/ajpcell.1994.266.1.c243

PubMed ID: 1851637

Title: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins.

PubMed ID: 1851637

DOI: 10.1016/0005-2760(91)90128-5

PubMed ID: 8250832

Title: Lipoxin synthase activity of human platelet 12-lipoxygenase.

PubMed ID: 8250832

DOI: 10.1042/bj2960127

PubMed ID: 8319693

Title: Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.

PubMed ID: 8319693

DOI: 10.1111/j.1432-1033.1993.tb17988.x

PubMed ID: 8500694

Title: Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies.

PubMed ID: 8500694

DOI: 10.1096/fasebj.7.8.8500694

PubMed ID: 8912711

Title: 12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.

PubMed ID: 8912711

DOI: 10.1006/excr.1996.0317

PubMed ID: 9751607

Title: Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

PubMed ID: 9751607

PubMed ID: 16638750

Title: Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.

PubMed ID: 16638750

DOI: 10.1074/jbc.m601887200

PubMed ID: 17493578

Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.

PubMed ID: 17493578

DOI: 10.1016/j.abb.2007.04.007

PubMed ID: 18311922

Title: Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.

PubMed ID: 18311922

DOI: 10.1021/bi702530z

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 22237009

Title: Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.

PubMed ID: 22237009

DOI: 10.1016/j.yexcr.2011.12.017

PubMed ID: 23578768

Title: 12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival.

PubMed ID: 23578768

DOI: 10.1016/j.yexcr.2013.04.001

PubMed ID: 22984144

Title: Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.

PubMed ID: 22984144

DOI: 10.1194/jlr.m026385

PubMed ID: 23504711

Title: The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.

PubMed ID: 23504711

DOI: 10.1096/fj.13-227728

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 25036362

Title: Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.

PubMed ID: 25036362

DOI: 10.1371/journal.pone.0102362

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 15308583

Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.

PubMed ID: 15308583

DOI: 10.1093/carcin/bgh260

PubMed ID: 17151091

Title: Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.

PubMed ID: 17151091

DOI: 10.1093/carcin/bgl242

PubMed ID: 17460548

Title: Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.

PubMed ID: 17460548

DOI: 10.1097/fpc.0b013e328010bda1

Sequence Information:

  • Length: 663
  • Mass: 75694
  • Checksum: C4D6D5B320666A77
  • Sequence:
    • MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL 
QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA 
LDMFQKHREK ELKDRQQIYC WATWKEGLPL TIAADRKDDL PPNMRFHEEK RLDFEWTLKA 
GALEMALKRV YTLLSSWNCL EDFDQIFWGQ KSALAEKVRQ CWQDDELFSY QFLNGANPML 
LRRSTSLPSR LVLPSGMEEL QAQLEKELQN GSLFEADFIL LDGIPANVIR GEKQYLAAPL 
VMLKMEPNGK LQPMVIQIQP PNPSSPTPTL FLPSDPPLAW LLAKSWVRNS DFQLHEIQYH 
LLNTHLVAEV IAVATMRCLP GLHPIFKFLI PHIRYTMEIN TRARTQLISD GGIFDKAVST 
GGGGHVQLLR RAAAQLTYCS LCPPDDLADR GLLGLPGALY AHDALRLWEI IARYVEGIVH 
LFYQRDDIVK GDPELQAWCR EITEVGLCQA QDRGFPVSFQ SQSQLCHFLT MCVFTCTAQH 
AAINQGQLDW YAWVPNAPCT MRMPPPTTKE DVTMATVMGS LPDVRQACLQ MAISWHLSRR 
QPDMVPLGHH KEKYFSGPKP KAVLNQFRTD LEKLEKEITA RNEQLDWPYE YLKPSCIENS 
VTI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.