Details for: ALOX12
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 27.2590
Cell Significance Index: -4.2400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 16.7164
Cell Significance Index: -4.2400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 9.6815
Cell Significance Index: -4.9800 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: 0.7367
Cell Significance Index: 10.3400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1781
Cell Significance Index: 35.3500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.1326
Cell Significance Index: 91.7200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1023
Cell Significance Index: 1.2200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0520
Cell Significance Index: 10.4300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0434
Cell Significance Index: 0.4000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0416
Cell Significance Index: 2.5600 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.0414
Cell Significance Index: 0.2800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0273
Cell Significance Index: 4.9300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0195
Cell Significance Index: 1.2300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.0190
Cell Significance Index: 0.3700 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.0186
Cell Significance Index: 0.2800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0156
Cell Significance Index: 21.2600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.0147
Cell Significance Index: 0.6500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0111
Cell Significance Index: 3.9800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0097
Cell Significance Index: 17.8300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0094
Cell Significance Index: 14.4000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0081
Cell Significance Index: 0.1100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0075
Cell Significance Index: 3.3100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0061
Cell Significance Index: 0.7500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0059
Cell Significance Index: 11.1300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.0021
Cell Significance Index: 0.0800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0019
Cell Significance Index: -0.1000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0038
Cell Significance Index: -2.4200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0054
Cell Significance Index: -0.1400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0056
Cell Significance Index: -0.8100 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0062
Cell Significance Index: -2.8300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0064
Cell Significance Index: -4.7500 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0066
Cell Significance Index: -3.6100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0084
Cell Significance Index: -4.7100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0110
Cell Significance Index: -3.1700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0140
Cell Significance Index: -0.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0214
Cell Significance Index: -1.6400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0226
Cell Significance Index: -3.8600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0255
Cell Significance Index: -5.3800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0273
Cell Significance Index: -1.9300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0277
Cell Significance Index: -1.4400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0286
Cell Significance Index: -3.9300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.0315
Cell Significance Index: -0.6900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0343
Cell Significance Index: -0.9200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0356
Cell Significance Index: -3.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0358
Cell Significance Index: -2.0100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0381
Cell Significance Index: -4.3700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0427
Cell Significance Index: -5.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0436
Cell Significance Index: -5.0800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0497
Cell Significance Index: -3.3400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0505
Cell Significance Index: -1.4100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0564
Cell Significance Index: -1.2100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0584
Cell Significance Index: -2.7300 - Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: -0.0605
Cell Significance Index: -0.4400 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0621
Cell Significance Index: -2.2800 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0659
Cell Significance Index: -2.8700 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.0683
Cell Significance Index: -0.9700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0685
Cell Significance Index: -3.2200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0716
Cell Significance Index: -1.9500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0724
Cell Significance Index: -1.2400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0772
Cell Significance Index: -1.8700 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0791
Cell Significance Index: -4.1200 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0801
Cell Significance Index: -1.9200 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.0832
Cell Significance Index: -1.1100 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0853
Cell Significance Index: -2.1300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0863
Cell Significance Index: -3.9100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0912
Cell Significance Index: -1.9100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0920
Cell Significance Index: -2.9300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0953
Cell Significance Index: -3.3400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0955
Cell Significance Index: -2.5500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0990
Cell Significance Index: -3.2400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1013
Cell Significance Index: -2.9200 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1145
Cell Significance Index: -1.9800 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1152
Cell Significance Index: -2.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1266
Cell Significance Index: -4.4500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.1268
Cell Significance Index: -4.0100 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.1275
Cell Significance Index: -1.5900 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.1362
Cell Significance Index: -2.2900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1364
Cell Significance Index: -4.7400 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.1364
Cell Significance Index: -1.9400 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1391
Cell Significance Index: -3.4700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.1427
Cell Significance Index: -2.4600 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.1442
Cell Significance Index: -1.8200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1461
Cell Significance Index: -3.1000 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1493
Cell Significance Index: -6.1200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.1535
Cell Significance Index: -4.5200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1547
Cell Significance Index: -3.2100 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.1566
Cell Significance Index: -4.1900 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.1569
Cell Significance Index: -3.1500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1571
Cell Significance Index: -2.3200 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1586
Cell Significance Index: -4.0400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1591
Cell Significance Index: -4.5600 - Cell Name: neuron (CL0000540)
Fold Change: -0.1604
Cell Significance Index: -1.5200 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.1632
Cell Significance Index: -2.3700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1666
Cell Significance Index: -3.3000 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.1672
Cell Significance Index: -1.9700 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.1675
Cell Significance Index: -3.5000 - Cell Name: primitive red blood cell (CL0002355)
Fold Change: -0.1687
Cell Significance Index: -1.9100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1689
Cell Significance Index: -4.8200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1693
Cell Significance Index: -1.8400 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.1700
Cell Significance Index: -3.4600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2812426038
Symbol: LOX12_HUMAN
Name: Lipoxin synthase 12-LO
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2244907
Title: Molecular cloning and expression of human arachidonate 12-lipoxygenase.
PubMed ID: 2244907
PubMed ID: 2377602
Title: Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.
PubMed ID: 2377602
PubMed ID: 2217179
Title: Cloning of the cDNA for human 12-lipoxygenase.
PubMed ID: 2217179
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1447217
Title: Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.
PubMed ID: 1447217
PubMed ID: 1570320
Title: Characterization of human 12-lipoxygenase genes.
PubMed ID: 1570320
PubMed ID: 8304420
Title: Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis.
PubMed ID: 8304420
PubMed ID: 1851637
Title: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins.
PubMed ID: 1851637
PubMed ID: 8250832
Title: Lipoxin synthase activity of human platelet 12-lipoxygenase.
PubMed ID: 8250832
DOI: 10.1042/bj2960127
PubMed ID: 8319693
Title: Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system.
PubMed ID: 8319693
PubMed ID: 8500694
Title: Structure-function properties of human platelet 12-lipoxygenase: chimeric enzyme and in vitro mutagenesis studies.
PubMed ID: 8500694
PubMed ID: 8912711
Title: 12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization.
PubMed ID: 8912711
PubMed ID: 9751607
Title: Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
PubMed ID: 9751607
PubMed ID: 16638750
Title: Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells.
PubMed ID: 16638750
PubMed ID: 17493578
Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.
PubMed ID: 17493578
PubMed ID: 18311922
Title: Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.
PubMed ID: 18311922
DOI: 10.1021/bi702530z
PubMed ID: 18755188
Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.
PubMed ID: 18755188
PubMed ID: 22237009
Title: Up-regulation of 12(S)-lipoxygenase induces a migratory phenotype in colorectal cancer cells.
PubMed ID: 22237009
PubMed ID: 23578768
Title: 12S-Lipoxygenase is necessary for human vascular smooth muscle cell survival.
PubMed ID: 23578768
PubMed ID: 22984144
Title: Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation.
PubMed ID: 22984144
DOI: 10.1194/jlr.m026385
PubMed ID: 23504711
Title: The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.
PubMed ID: 23504711
DOI: 10.1096/fj.13-227728
PubMed ID: 24282679
Title: Functional characterization of genetic enzyme variations in human lipoxygenases.
PubMed ID: 24282679
PubMed ID: 25036362
Title: Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages.
PubMed ID: 25036362
PubMed ID: 32404334
Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.
PubMed ID: 32404334
PubMed ID: 15308583
Title: Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk.
PubMed ID: 15308583
PubMed ID: 17151091
Title: Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
PubMed ID: 17151091
PubMed ID: 17460548
Title: Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
PubMed ID: 17460548
Sequence Information:
- Length: 663
- Mass: 75694
- Checksum: C4D6D5B320666A77
- Sequence:
MGRYRIRVAT GAWLFSGSYN RVQLWLVGTR GEAELELQLR PARGEEEEFD HDVAEDLGLL QFVRLRKHHW LVDDAWFCDR ITVQGPGACA EVAFPCYRWV QGEDILSLPE GTARLPGDNA LDMFQKHREK ELKDRQQIYC WATWKEGLPL TIAADRKDDL PPNMRFHEEK RLDFEWTLKA GALEMALKRV YTLLSSWNCL EDFDQIFWGQ KSALAEKVRQ CWQDDELFSY QFLNGANPML LRRSTSLPSR LVLPSGMEEL QAQLEKELQN GSLFEADFIL LDGIPANVIR GEKQYLAAPL VMLKMEPNGK LQPMVIQIQP PNPSSPTPTL FLPSDPPLAW LLAKSWVRNS DFQLHEIQYH LLNTHLVAEV IAVATMRCLP GLHPIFKFLI PHIRYTMEIN TRARTQLISD GGIFDKAVST GGGGHVQLLR RAAAQLTYCS LCPPDDLADR GLLGLPGALY AHDALRLWEI IARYVEGIVH LFYQRDDIVK GDPELQAWCR EITEVGLCQA QDRGFPVSFQ SQSQLCHFLT MCVFTCTAQH AAINQGQLDW YAWVPNAPCT MRMPPPTTKE DVTMATVMGS LPDVRQACLQ MAISWHLSRR QPDMVPLGHH KEKYFSGPKP KAVLNQFRTD LEKLEKEITA RNEQLDWPYE YLKPSCIENS VTI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.