Genular: Defining Cellular Identity and Function

Details for: Impdh2

Gene ID: 23918

Symbol: Impdh2

Ensembl ID: ENSMUSG00000062867

Description: inosine monophosphate dehydrogenase 2

Associated with

Azathioprine adme
(R-MMU-9748787)
Drug adme
(R-MMU-9748784)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism
(R-MMU-1430728)
Metabolism of nucleotides
(R-MMU-15869)
Neutrophil degranulation
(R-MMU-6798695)
Nucleotide biosynthesis
(R-MMU-8956320)
Purine ribonucleoside monophosphate biosynthesis
(R-MMU-73817)
'de novo' xmp biosynthetic process
(GO:0097294)
Catalytic activity
(GO:0003824)
Cellular response to interleukin-4
(GO:0071353)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Gmp biosynthetic process
(GO:0006177)
Gmp salvage
(GO:0032263)
Gtp biosynthetic process
(GO:0006183)
Identical protein binding
(GO:0042802)
Imp dehydrogenase activity
(GO:0003938)
Lymphocyte proliferation
(GO:0046651)
Metal ion binding
(GO:0046872)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Oxidoreductase activity
(GO:0016491)
Purine nucleotide biosynthetic process
(GO:0006164)
Rna binding
(GO:0003723)

Other Information

Proteins

IMPDH-II

Genular Protein ID: 2393895453

Symbol: IMDH2_MOUSE

Name: IMPDH-II

UniProtKB Accession Codes:

P24547 Q61734 Q91Z11

Database IDs:

Citations:

PubMed ID: 1671845

Title: Isolation and sequence of a cDNA encoding mouse IMP dehydrogenase.

PubMed ID: 1671845

DOI: 10.1016/0378-1119(91)90065-j

PubMed ID: 7906545

Title: Gene amplification and dual point mutations of mouse IMP dehydrogenase associated with cellular resistance to mycophenolic acid.

PubMed ID: 7906545

DOI: 10.1016/0167-4781(94)90029-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2572589

Title: Increased activity, amount, and altered kinetic properties of IMP dehydrogenase from mycophenolic acid-resistant neuroblastoma cells.

PubMed ID: 2572589

DOI: 10.1016/s0021-9258(19)84687-2

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 514
Mass: 55815
Checksum: 17D25A5C5EBCC439
Sequence:

MADYLISGGT SYVPDDGLTA QQLFNCGDGL TYNDFLILPG YIDFTADQVD LTSALTKKIT 
LKTPLVSSPM DTVTEAGMAI AMALTGGIGF IHHNCTPEFQ ANEVRKVKKY EQGFITDPVV 
LSPKDRVRDV FEAKARHGFC GIPITDTGRM GSRLVGIISS RDIDFLKEEE HDRFLEEIMT 
KREDLVVAPA GVTLKEANEI LQRSKKGKLP IVNENDELVA IIARTDLKKN RDYPLASKDA 
KKQLLCGAAI GTHEDDKYRL DLLALAGVDV VVLDSSQGNS IFQINMIKYI KEKYPSLQVI 
GGNVVTAAQA KNLIDAGVDA LRVGMGSGSI CITQEVLACG RPQATAVYKV SEYARRFGVP 
VIADGGIQNV GHIAKALALG ASTVMMGSLL AATTEAPGEY FFSDGIRLKK YRGMGSLDAM 
DKHLSSQNRY FSEADKIKVA QGVSGAVQDK GSIHKFVPYL IAGIQHSCQD IGAKSLTQVR 
AMMYSGELKF EKRTSSAQVE GGVHSLHSYE KRLF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Impdh2

Associated with

Other Information

Isolation and sequence of a cDNA encoding mouse IMP dehydrogenase. PubMed ID: 1671845

Gene amplification and dual point mutations of mouse IMP dehydrogenase associated with cellular resistance to mycophenolic acid. PubMed ID: 7906545

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334