Genular: Defining Cellular Identity and Function

Details for: Map2k5

Gene ID: 23938

Symbol: Map2k5

Ensembl ID: ENSMUSG00000058444

Description: mitogen-activated protein kinase kinase 5

Associated with

Atp binding
(GO:0005524)
Cellular response to growth factor stimulus
(GO:0071363)
Cytoplasm
(GO:0005737)
Erk5 cascade
(GO:0070375)
Heart development
(GO:0007507)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Kinase activity
(GO:0016301)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Metal ion binding
(GO:0046872)
Negative regulation of cell migration involved in sprouting angiogenesis
(GO:0090051)
Negative regulation of chemokine (c-x-c motif) ligand 2 production
(GO:2000342)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of heterotypic cell-cell adhesion
(GO:0034115)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of response to cytokine stimulus
(GO:0060761)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleotide binding
(GO:0000166)
Phosphorylation
(GO:0016310)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein tyrosine kinase activity
(GO:0004713)
Spindle
(GO:0005819)
Transferase activity
(GO:0016740)

Other Information

Proteins

Dual specificity mitogen-activated protein kinase kinase 5

Genular Protein ID: 4282285030

Symbol: MP2K5_MOUSE

Name: Dual specificity mitogen-activated protein kinase kinase 5

UniProtKB Accession Codes:

Q9WVS7 Q8CFM3 Q8K360 Q9D222

Database IDs:

Citations:

PubMed ID: 10473620

Title: Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus.

PubMed ID: 10473620

DOI: 10.1074/jbc.274.37.26563

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12813044

Title: Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.

PubMed ID: 12813044

DOI: 10.1074/jbc.m303221200

PubMed ID: 16507987

Title: PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation.

PubMed ID: 16507987

DOI: 10.1128/mcb.26.6.2065-2079.2006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 448
Mass: 50105
Checksum: 50C50E8F0F712BE7
Sequence:

MLWLALGPFC AMENQVLVIR IKIPNSGAVD WTVHSGPQLL FRDVLDVIGQ VLPEATTTAF 
EYEDEDGDRI TVRSDEEMKA MLSYYYSTVM EQQVNGQLIE PLQIFPRACK PPGERNIHGL 
KVNTRAGPSQ HTSPVVSDSL PSNSLKKSSA ELRKILANGQ MNEQDIRYRD TLGHGNGGTV 
YKAHHVPSGK ILAVKVILLD ITLELQKQIM SELEILYKCD SSYIIGFYGA FFVENRISIC 
TEFMDGGSLD VYRKIPEHVL GRIAVAVVKG LTYLWSLKIL HRDVKPSNML VNTGGQVKLC 
DFGVSTQLVN SIAKTYVGTN AYMAPERISG EQYGIHSDVW SLGISFMELA LGRFPYPQIQ 
KNQGSLMPLQ LLQCIVDEDS PVLPLGEFSE PFVHFITQCM RKQPKERPAP EELMGHPFIV 
QFNDGNSTVV SMWVCRALEE RRSQQGPP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map2k5

Associated with

Other Information

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. PubMed ID: 10473620

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. PubMed ID: 12813044

PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. PubMed ID: 16507987