Genular: Defining Cellular Identity and Function

Details for: Mapk7

Gene ID: 23939

Symbol: Mapk7

Ensembl ID: ENSMUSG00000001034

Description: mitogen-activated protein kinase 7

Associated with

Axon guidance
(R-MMU-422475)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Erk/mapk targets
(R-MMU-198753)
Erks are inactivated
(R-MMU-202670)
G alpha (q) signalling events
(R-MMU-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-MMU-881907)
Gpcr downstream signalling
(R-MMU-388396)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-MMU-450282)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nervous system development
(R-MMU-9675108)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Ret signaling
(R-MMU-8853659)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signaling by gpcr
(R-MMU-372790)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signalling to erk5
(R-MMU-198765)
Signal transduction
(R-MMU-162582)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Atp binding
(GO:0005524)
Calcineurin-nfat signaling cascade
(GO:0033173)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to laminar fluid shear stress
(GO:0071499)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Erk5 cascade
(GO:0070375)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Mapk cascade
(GO:0000165)
Map kinase activity
(GO:0004707)
Mitogen-activated protein kinase binding
(GO:0051019)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcineurin-nfat signaling cascade
(GO:0070885)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
(GO:2001240)
Negative regulation of heterotypic cell-cell adhesion
(GO:0034115)
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
(GO:1902176)
Negative regulation of response to cytokine stimulus
(GO:0060761)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Phosphorylation
(GO:0016310)
Pml body
(GO:0016605)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of angiogenesis
(GO:0045765)
Transferase activity
(GO:0016740)

Other Information

Proteins

Mitogen-activated protein kinase 7
Q5NCN8_MOUSE

Genular Protein ID: 2500802490

Symbol: MK07_MOUSE

Name: Mitogen-activated protein kinase 7

UniProtKB Accession Codes:

Q9WVS8 Q3U2N7 Q3UG52 Q497T0 Q5NCN6 Q5NCN7 Q5NCN9 Q6QLU8 Q9R1D9 Q9WVF3 Q9WVF4

Database IDs:

Citations:

PubMed ID: 10473620

Title: Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus.

PubMed ID: 10473620

DOI: 10.1074/jbc.274.37.26563

PubMed ID: 11139578

Title: Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains.

PubMed ID: 11139578

DOI: 10.1074/jbc.m009286200

PubMed ID: 15716121

Title: Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant.

PubMed ID: 15716121

DOI: 10.1016/j.gene.2004.11.011

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 11520859

Title: Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells.

PubMed ID: 11520859

DOI: 10.1093/embo-reports/kve177

PubMed ID: 11278431

Title: Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival.

PubMed ID: 11278431

DOI: 10.1074/jbc.m008748200

PubMed ID: 15085193

Title: Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.

PubMed ID: 15085193

DOI: 10.1172/jci19890

PubMed ID: 23428871

Title: Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.

PubMed ID: 23428871

DOI: 10.1128/mcb.01246-12

Sequence Information:

Length: 806
Mass: 87733
Checksum: E7CC41C4BBDE0633
Sequence:

MAEPLKEEDG EDGSGEPPGR VKAEPVHTAA SVVAKNLALL KARSFDVTFD VGDEYEIIET 
IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL RELKILKHFK HDNIIAIKDI 
LKPTVPYGEF RSVYVVLDLM ESDLHQIIHS SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH 
RDLKPSNLLV NENCELKIGD FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT 
QAIDLWSVGC IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS 
LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY HDPDDEPDCA 
PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR FQPSLQPVAS EPVCPDVEMP 
SPWAPSGDCA MESPPPALPP CSDPAPDTVD LTLQPAPPAS ELAPPKREGA ISDNTKAALK 
AALLKSLRSR LRDGPSAPLE APEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER 
KERGAGTLGG PSTDPLAGLV LSDNDRSLLE RWTRMARPPA PAPAPAPAPA PAPSSAQPTS 
TPTGPVSQST GPLQPAGSIP GPASQPVCPP PGPVPQPAGP IPAPLQTAPS TSLLASQSLV 
PPSGLPGSGA PEVLPYFPSG PPPPDPGLTP QPSTSESPDV NLVTQQLSKS QVEDPLPPVF 
SGTPKGSGAG YGVGFDLEEF LNQSFDMGVA DGPQDGQADS ASLSASLLAD WLEGHGMNPA 
DIESLQREIQ MDSPMLLSDL PDLQEP

Genular Protein ID: 4174495630

Symbol: Q5NCN8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5NCN8

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 703
Mass: 76766
Checksum: 88B2A5E2060A74E3
Sequence:

MPFSCSPGQQ VAIKKIPNAF DVVTNAKRTL RELKILKHFK HDNIIAIKDI LKPTVPYGEF 
RSVYVVLDLM ESDLHQIIHS SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH RDLKPSNLLV 
NENCELKIGD FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT QAIDLWSVGC 
IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS LPPRQPVPWE 
TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY HDPDDEPDCA PPFDFAFDRE 
ALTRERIKEA IVAEIEDFHA RREGIRQQIR FQPSLQPVAS EPVCPDVEMP SPWAPSGDCA 
MESPPPALPP CSDPAPDTVD LTLQPAPPAN GPSAPLEAPE PRKPVTAQER QREREEKRRR 
RQERAKEREK RRQERERKER GAGTLGGPST DPLAGLVLSD NDRSLLERWT RMARPPAPAP 
APAPAPAPAP SSAQPTSTPT GPVSQSTGPL QPAGSIPGPA SQPVCPPPGP VPQPAGPIPA 
PLQTAPSTSL LASQSLVPPS GLPGSGAPEV LPYFPSGPPP PDPGLTPQPS TSESPDVNLV 
TQQLSKSQVE DPLPPVFSGT PKGSGAGYGV GFDLEEFLNQ SFDMGVADGP QDGQADSASL 
SASLLADWLE GHGMNPADIE SLQREIQMDS PMLLSDLPDL QEP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mapk7

Associated with

Other Information

Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. PubMed ID: 10473620

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains. PubMed ID: 11139578

Identification and characterization of mErk5-T, a novel Erk5/Bmk1 splice variant. PubMed ID: 15716121

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells. PubMed ID: 11520859

Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C. Regulation of cell proliferation and survival. PubMed ID: 11278431

Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. PubMed ID: 15085193

Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. PubMed ID: 23428871

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 10473620

PubMed ID: 11139578

PubMed ID: 15716121

PubMed ID: 16141072

PubMed ID: 15489334

PubMed ID: 19468303

PubMed ID: 11520859

PubMed ID: 11278431

PubMed ID: 15085193

PubMed ID: 23428871

PubMed ID: 19468303