Genular: Defining Cellular Identity and Function

Details for: Mta2

Gene ID: 23942

Symbol: Mta2

Ensembl ID: ENSMUSG00000071646

Description: metastasis-associated gene family, member 2

Associated with

Chromatin modifying enzymes
(R-MMU-3247509)
Chromatin organization
(R-MMU-4839726)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdacs deacetylate histones
(R-MMU-3214815)
Intracellular signaling by second messengers
(R-MMU-9006925)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten gene transcription
(R-MMU-8943724)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i transcription
(R-MMU-73864)
Rna polymerase i transcription initiation
(R-MMU-73762)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by tp53
(R-MMU-3700989)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Chromosome, telomeric region
(GO:0000781)
Chromosome organization
(GO:0051276)
Dna binding
(GO:0003677)
Dna methylation
(GO:0006306)
Histone deacetylase activity
(GO:0004407)
Histone deacetylase binding
(GO:0042826)
Histone deacetylase complex
(GO:0000118)
Metal ion binding
(GO:0046872)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Nurd complex
(GO:0016581)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of cell fate specification
(GO:0042659)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of fibroblast migration
(GO:0010762)
Regulation of stem cell differentiation
(GO:2000736)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Sequence-specific dna binding
(GO:0043565)
Transcription coactivator activity
(GO:0003713)
Transcription coregulator activity
(GO:0003712)
Transcription corepressor activity
(GO:0003714)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Metastasis-associated protein MTA2

Genular Protein ID: 14311993

Symbol: MTA2_MOUSE

Name: Metastasis-associated protein MTA2

UniProtKB Accession Codes:

Q9R190 Q3TVT8

Database IDs:

Citations:

PubMed ID: 10444591

Title: Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.

PubMed ID: 10444591

DOI: 10.1101/gad.13.15.1924

PubMed ID: 11368903

Title: Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression.

PubMed ID: 11368903

DOI: 10.1016/s0378-1119(01)00429-2

PubMed ID: 11749719

Title: Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor.

PubMed ID: 11749719

DOI: 10.1089/104454901753340596

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10984530

Title: Identification of a nuclear domain with deacetylase activity.

PubMed ID: 10984530

DOI: 10.1073/pnas.97.19.10330

PubMed ID: 12124384

Title: The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2.

PubMed ID: 12124384

DOI: 10.1074/jbc.m203455200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 27806305

Title: A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.

PubMed ID: 27806305

DOI: 10.1016/j.celrep.2016.10.022

PubMed ID: 34180153

Title: PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

PubMed ID: 34180153

DOI: 10.1002/advs.202102060

Sequence Information:

Length: 668
Mass: 75030
Checksum: 88996F779BA6F4D1
Sequence:

MAANMYRVGD YVYFENSSSN PYLVRRIEEL NKTANGNVEA KVVCLFRRRD ISSSLNSLAD 
SNAREFEEES KQPGVSEQQR HQLKHRELFL SRQFESLPAT HIRGKCSVTL LNETDILNQY 
LDKEDCFFYS LVFDPVQKTL LADQGEIRVG CKFQAEIPDR LAEGESDNRN QQKMEMKVWD 
PDNPLTDRQI DQFLVVARAV GTFARALDCS SSIRQPSLHM SAAAASRDIT LFHAMDTLQR 
NGYDLAKAMS TLVPQGGPVL CRDEMEEWSA SEAMLFEEAL EKYGKDFNDI RQDFLPWKSL 
ASIVQFYYMW KTTDRYIQQK RLKAAEADSK LKQVYIPTYT KPNPNQIISV GSKPGMNGAG 
FQKGLTCESC HTTQSAQWYA WGPPNMQCRL CASCWIYWKK YGGLKTPTQL EGAARGTTEP 
HSRGHLSRPE AQSLSPYTTS ANRAKLLAKN RQTFLLQTTK LTRLARRMCR DLLQPRRAAR 
RPYAPINANA IKAECSIRLP KAAKTPLKIH PLVRLPLATI VKDLVAQAPL KPKTPRGTKT 
PINRNQLTQN RGLGGIMVKR SYETMAGAGV PFSANGRPLA SGIRSSSQPA AKRQKLNPAD 
APNPVVFVAT KDTRALRKAL THLEMRRAAR RPNLPLKVKP TLMTVRPPVP LPASSHPAST 
NEPIVLED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mta2

Associated with

Other Information

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. PubMed ID: 10444591

Sp1 and ETS family transcription factors regulate the mouse Mta2 gene expression. PubMed ID: 11368903

Characterization of mouse metastasis-associated gene 2: genomic structure, nuclear localization signal, and alternative potentials as transcriptional activator and repressor. PubMed ID: 11749719

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a nuclear domain with deacetylase activity. PubMed ID: 10984530

The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. PubMed ID: 12124384

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development. PubMed ID: 27806305

PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex. PubMed ID: 34180153