Genular: Defining Cellular Identity and Function

Details for: Nr0b2

Gene ID: 23957

Symbol: Nr0b2

Ensembl ID: ENSMUSG00000037583

Description: nuclear receptor subfamily 0, group B, member 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Nuclear receptor transcription pathway
(R-MMU-383280)
Rna polymerase ii transcription
(R-MMU-73857)
Chromatin
(GO:0000785)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Cytoplasm
(GO:0005737)
Intracellular membrane-bounded organelle
(GO:0043231)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nuclear retinoic acid receptor binding
(GO:0042974)
Nuclear retinoid x receptor binding
(GO:0046965)
Nuclear thyroid hormone receptor binding
(GO:0046966)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion
(GO:0032024)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Response to glucose
(GO:0009749)
Rhythmic process
(GO:0048511)
Transcription corepressor activity
(GO:0003714)
Transcription factor binding
(GO:0008134)
Transcription regulator inhibitor activity
(GO:0140416)

Other Information

Proteins

Nuclear receptor subfamily 0 group B member 2

Genular Protein ID: 3824267056

Symbol: NR0B2_MOUSE

Name: Nuclear receptor subfamily 0 group B member 2

UniProtKB Accession Codes:

Q62227 Q53Z53

Database IDs:

Citations:

PubMed ID: 8650544

Title: An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors.

PubMed ID: 8650544

DOI: 10.1126/science.272.5266.1336

PubMed ID: 12949731

Title: FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice.

PubMed ID: 12949731

DOI: 10.1016/s0016-5085(03)01053-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11964378

Title: A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP.

PubMed ID: 11964378

DOI: 10.1093/embo-reports/kvf087

PubMed ID: 14752053

Title: Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD.

PubMed ID: 14752053

DOI: 10.1210/me.2003-0311

PubMed ID: 21262773

Title: Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.

PubMed ID: 21262773

DOI: 10.1128/mcb.01212-10

PubMed ID: 25212631

Title: Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism.

PubMed ID: 25212631

DOI: 10.1002/hep.27437

PubMed ID: 30555544

Title: Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity.

PubMed ID: 30555544

DOI: 10.7150/thno.28676

PubMed ID: 15707893

Title: Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

PubMed ID: 15707893

DOI: 10.1016/j.cell.2005.01.024

Sequence Information:

Length: 260
Mass: 28763
Checksum: 7B859325AA73DCA1
Sequence:

MSSGQSGVCP CQGSAGRPTI LYALLSPSPR TRPVAPASHS HCLCQQQRPV RLCAPHRTCR 
EALDVLAKTV AFLRNLPSFC HLPHEDQRRL LECCWGPLFL LGLAQDAVTF EVAEAPVPSI 
LKKILLEEAS SGTQGAQPSD RPQPSLAAVQ WLQRCLESFW SLELGPKEYA YLKGTILFNP 
DVPGLRASCH IAHLQQEAHW ALCEVLEPWY PASQGRLARI LLMASTLKNI PGTLLVDLFF 
RPIMGDVDIT ELLEDMLLLR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr0b2

Associated with

Other Information

An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. PubMed ID: 8650544

FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. PubMed ID: 12949731

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. PubMed ID: 11964378

Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. PubMed ID: 14752053

Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner. PubMed ID: 21262773

Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. PubMed ID: 25212631

Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity. PubMed ID: 30555544

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. PubMed ID: 15707893