Details for: Oas1b

Gene ID: 23961

Symbol: Oas1b

Ensembl ID: ENSMUSG00000029605

Description: 2'-5' oligoadenylate synthetase 1B

Associated with

Other Information

Genular Protein ID: 1139097249

Symbol: OAS1B_MOUSE

Name: Inactive 2'-5'-oligoadenylate synthase 1B

UniProtKB Accession Codes:

Q60856 A8YPE5 A8YPE7 A8YPE8 A8YPE9 E9QKP6 Q78ZX0 Q8JZN0 Q8JZN4 Q8VI98

Database IDs:

AlphaFoldDB 1 BRENDA 1 BioGRID 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 15 GO 30 Gene3D 2 InParanoid 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMR 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 12396720

Title: Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family.

PubMed ID: 12396720

DOI: 10.1089/10799900260286696

PubMed ID: 12080145

Title: Positional cloning of the murine flavivirus resistance gene.

PubMed ID: 12080145

DOI: 10.1073/pnas.142287799

PubMed ID: 12186974

Title: A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.

PubMed ID: 12186974

DOI: 10.1073/pnas.172195399

PubMed ID: 18460447

Title: Long-term balancing selection at the west nile virus resistance gene, Oas1b, maintains transspecific polymorphisms in the house mouse.

PubMed ID: 18460447

DOI: 10.1093/molbev/msn106

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 1709495

Title: The murine 2-5A synthetase locus: three distinct transcripts from two linked genes.

PubMed ID: 1709495

DOI: 10.1093/nar/19.8.1917

PubMed ID: 16371364

Title: The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells.

PubMed ID: 16371364

DOI: 10.1074/jbc.m508649200

PubMed ID: 17024523

Title: The mammalian 2'-5' oligoadenylate synthetase gene family: evidence for concerted evolution of paralogous Oas1 genes in Rodentia and Artiodactyla.

PubMed ID: 17024523

DOI: 10.1007/s00239-006-0073-3

PubMed ID: 17904183

Title: Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype.

PubMed ID: 17904183

DOI: 10.1016/j.virol.2007.08.017

PubMed ID: 22623793

Title: Identification of novel host cell binding partners of Oas1b, the protein conferring resistance to flavivirus-induced disease in mice.

PubMed ID: 22623793

DOI: 10.1128/jvi.00333-12

PubMed ID: 22305621

Title: Activation of Oas1a gene expression by type I IFN requires both STAT1 and STAT2 while only STAT2 is required for Oas1b activation.

PubMed ID: 22305621

DOI: 10.1016/j.virol.2011.11.025

PubMed ID: 27663720

Title: The role of mouse 2',5'-oligoadenylate synthetase 1 paralogs.

PubMed ID: 27663720

DOI: 10.1016/j.meegid.2016.09.018

Sequence Information:

  • Length: 376
  • Mass: 43620
  • Checksum: 0733589FC702D4C7
  • Sequence:
    • MEQDLRSIPA SKLDKFIENH LPDTSFCADL REVIDALCAL LKDRSFRGPV RRMRASKGVK 
GKGTTLKGRS DADLVVFLNN LTSFEDQLNQ QGVLIKEIKK QLCEVQHERR CGVKFEVHSL 
RSPNSRALSF KLSAPDLLKE VKFDVLPAYD LLDHLNILKK PNQQFYANLI SGRTPPGKEG 
KLSICFMGLR KYFLNCRPTK LKRLIRLVTH WYQLCKEKLG DPLPPQYALE LLTVYAWEYG 
SRVTKFNTAQ GFRTVLELVT KYKQLQIYWT VYYDFRHQEV SEYLHQQLKK DRPVILDPAD 
PTRNIAGLNP KDWRRLAGEA AAWLQYPCFK YRDGSSVCSW EVPTEVGVPM KYLLCRIFWL 
LFWSLFHFIF GKTSSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.