Genular: Defining Cellular Identity and Function

Details for: Pacsin2

Gene ID: 23970

Symbol: Pacsin2

Ensembl ID: ENSMUSG00000016664

Description: protein kinase C and casein kinase substrate in neurons 2

Associated with

Clathrin-mediated endocytosis
(R-MMU-8856828)
Membrane trafficking
(R-MMU-199991)
Vesicle-mediated transport
(R-MMU-5653656)
Actin cytoskeleton organization
(GO:0030036)
Caveola
(GO:0005901)
Caveola assembly
(GO:0070836)
Caveolin-mediated endocytosis
(GO:0072584)
Cell-cell junction
(GO:0005911)
Cell projection
(GO:0042995)
Cell projection morphogenesis
(GO:0048858)
Centriolar satellite
(GO:0034451)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoskeletal protein binding
(GO:0008092)
Cytoskeleton
(GO:0005856)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Endocytosis
(GO:0006897)
Endosome
(GO:0005768)
Glutamatergic synapse
(GO:0098978)
Identical protein binding
(GO:0042802)
Intracellular membrane-bounded organelle
(GO:0043231)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of endocytosis
(GO:0045806)
Nuclear speck
(GO:0016607)
Phosphatidic acid binding
(GO:0070300)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Plasma membrane tubulation
(GO:0097320)
Protein binding
(GO:0005515)
Protein localization to endosome
(GO:0036010)
Recycling endosome membrane
(GO:0055038)
Regulation of endocytosis
(GO:0030100)
Signal transduction
(GO:0007165)
Trans-golgi network
(GO:0005802)

Other Information

Proteins

Protein kinase C and casein kinase substrate in neurons protein 2
Q8BNK9_MOUSE

Genular Protein ID: 176347638

Symbol: PACN2_MOUSE

Name: Protein kinase C and casein kinase substrate in neurons protein 2

UniProtKB Accession Codes:

Q9WVE8

Database IDs:

Citations:

PubMed ID: 10431838

Title: PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins.

PubMed ID: 10431838

DOI: 10.1016/s0014-5793(99)00830-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11082044

Title: All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.

PubMed ID: 11082044

DOI: 10.1242/jcs.113.24.4511

PubMed ID: 15930129

Title: EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.

PubMed ID: 15930129

DOI: 10.1091/mbc.e05-01-0076

PubMed ID: 16627472

Title: PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.

PubMed ID: 16627472

DOI: 10.1074/jbc.m602452200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20188097

Title: Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II.

PubMed ID: 20188097

DOI: 10.1016/j.febslet.2010.02.058

PubMed ID: 21610094

Title: Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting.

PubMed ID: 21610094

DOI: 10.1242/jcs.086264

PubMed ID: 21693584

Title: The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration.

PubMed ID: 21693584

DOI: 10.1242/jcs.080630

PubMed ID: 21807942

Title: Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis.

PubMed ID: 21807942

DOI: 10.1242/jcs.084319

PubMed ID: 23129763

Title: The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.

PubMed ID: 23129763

DOI: 10.1074/jbc.m112.391078

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 26092940

Title: Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane.

PubMed ID: 26092940

DOI: 10.1242/jcs.167775

PubMed ID: 20471395

Title: A hinge in the distal end of the PACSIN 2 F-BAR domain may contribute to membrane-curvature sensing.

PubMed ID: 20471395

DOI: 10.1016/j.jmb.2010.05.008

Sequence Information:

Length: 486
Mass: 55833
Checksum: 66C17ECCC767E0E7
Sequence:

MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCGD LMNCLHERAR IEKAYAQQLT 
EWARRWRQLV EKGPQYGTVE KAWIAVMSEA ERVSELHLEV KASLMNEDFE KIKNWQKEAF 
HKQMMGGFKE TKEAEDGFRK AQKPWAKKLK EVEAAKKAHH TACKEEKLAI SREANSKADP 
SLNPEQLKKL QDKIEKCKQD VLKTKDKYEK SLKELDQTTP QYMENMEQVF EQCQQFEEKR 
LRFFREVLLE VQKHLDLSNV ASYKTIYREL EQSIKAADAV EDLRWFRANH GPGMAMNWPQ 
FEEWSADLNR TLSRREKKKA VDGVTLTGIN QTGDQSGQNK PGSNLSVPSN PAQSTQLQSS 
YNPFEDEDDT GSSISEKEDI KAKNVSSYEK TQTYPTDWSD DESNNPFSST DANGDSNPFD 
EDTTSGTEVR VRALYDYEGQ EHDELSFKAG DELTKIEDED EQGWCKGRLD SGQVGLYPAN 
YVEAIQ

Genular Protein ID: 1218446246

Symbol: Q8BNK9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BNK9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 122
Mass: 13649
Checksum: 975E111A0B5A9FF5
Sequence:

EDEDDTGSSI SEKEDIKAKN VSSYEKTQTY PTDWSDDESN NPFSSTDANG DSNPFDEDTT 
SGTEVRVRAL YDYEGQEHDE LSFKAGDELT KIEDEDEQGW CKGRLDSGQV GLYPANYVEA 
IQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pacsin2

Associated with

Other Information

PACSIN 2, a novel member of the PACSIN family of cytoplasmic adapter proteins. PubMed ID: 10431838

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis. PubMed ID: 11082044

EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. PubMed ID: 15930129

PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. PubMed ID: 16627472

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II. PubMed ID: 20188097

Essential role of PACSIN2/syndapin-II in caveolae membrane sculpting. PubMed ID: 21610094

The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration. PubMed ID: 21693584

Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. PubMed ID: 21807942

The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization. PubMed ID: 23129763

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Phosphorylation of PACSIN2 by protein kinase C triggers the removal of caveolae from the plasma membrane. PubMed ID: 26092940

A hinge in the distal end of the PACSIN 2 F-BAR domain may contribute to membrane-curvature sensing. PubMed ID: 20471395

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073