Genular: Defining Cellular Identity and Function

Details for: Pin1

Gene ID: 23988

Symbol: Pin1

Ensembl ID: ENSMUSG00000032171

Description: peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1

Associated with

Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Negative regulators of ddx58/ifih1 signaling
(R-MMU-936440)
Pi5p regulates tp53 acetylation
(R-MMU-6811555)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by tp53
(R-MMU-3700989)
Beta-catenin binding
(GO:0008013)
Cell cycle
(GO:0007049)
Ciliary basal body
(GO:0036064)
Cis-trans isomerase activity
(GO:0016859)
Cytoplasm
(GO:0005737)
Cytoskeletal motor activity
(GO:0003774)
Cytosol
(GO:0005829)
Glutamatergic synapse
(GO:0098978)
Gtpase activating protein binding
(GO:0032794)
Isomerase activity
(GO:0016853)
Midbody
(GO:0030496)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of protein catabolic process
(GO:0042177)
Negative regulation of smad protein signal transduction
(GO:0060392)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-prolyl cis-trans isomerase activity
(GO:0003755)
Phosphoprotein binding
(GO:0051219)
Phosphoserine residue binding
(GO:0050815)
Phosphothreonine residue binding
(GO:0050816)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell growth involved in cardiac muscle cell development
(GO:0061051)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein dephosphorylation
(GO:0035307)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynapse
(GO:0098794)
Postsynaptic cytosol
(GO:0099524)
Protein binding
(GO:0005515)
Protein peptidyl-prolyl isomerization
(GO:0000413)
Protein stabilization
(GO:0050821)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cytokinesis
(GO:0032465)
Regulation of gene expression
(GO:0010468)
Regulation of protein localization to nucleus
(GO:1900180)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of protein stability
(GO:0031647)
Regulation protein catabolic process at postsynapse
(GO:0140252)
Response to hypoxia
(GO:0001666)
Synapse
(GO:0045202)
Synapse organization
(GO:0050808)
Ubiquitin ligase activator activity
(GO:1990757)

Other Information

Proteins

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Genular Protein ID: 67819368

Symbol: PIN1_MOUSE

Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

UniProtKB Accession Codes:

Q9QUR7 Q543B3

Database IDs:

Citations:

PubMed ID: 10600477

Title: Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest.

PubMed ID: 10600477

DOI: 10.1006/bbrc.1999.1736

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16024801

Title: Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint.

PubMed ID: 16024801

DOI: 10.1128/mcb.25.15.6660-6672.2005

PubMed ID: 17828269

Title: Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

PubMed ID: 17828269

DOI: 10.1038/ni1508

PubMed ID: 19367327

Title: Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development.

PubMed ID: 19367327

DOI: 10.1038/ki.2009.95

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 29686383

Title: The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation.

PubMed ID: 29686383

DOI: 10.1038/s41467-018-03886-6

Sequence Information:

Length: 165
Mass: 18370
Checksum: 188E95F009176B1F
Sequence:

MADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGG STVGGSSKNG QGEPAKVRCS 
HLLVKHSQSR RPSSWRQEKI TRSKEEALEL INGYIQKIKS GEEDFESLAS QFSDCSSAKA 
RGDLGPFSRG QMQKPFEDAS FALRTGEMSG PVFTDSGIHI ILRTE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pin1

Associated with

Other Information

Mice lacking Pin1 develop normally, but are defective in entering cell cycle from G0 arrest. PubMed ID: 10600477

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. PubMed ID: 16024801

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells. PubMed ID: 17828269

Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development. PubMed ID: 19367327

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation. PubMed ID: 29686383