Genular: Defining Cellular Identity and Function

Details for: Tiam2

Gene ID: 24001

Symbol: Tiam2

Ensembl ID: ENSMUSG00000023800

Description: T cell lymphoma invasion and metastasis 2

Associated with

Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Death receptor signaling
(R-MMU-73887)
G alpha (12/13) signalling events
(R-MMU-416482)
Gpcr downstream signalling
(R-MMU-388396)
Nrage signals death through jnk
(R-MMU-193648)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
Rac1 gtpase cycle
(R-MMU-9013149)
Rho gtpase cycle
(R-MMU-9012999)
Signaling by gpcr
(R-MMU-372790)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Activation of gtpase activity
(GO:0090630)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Gtpase activator activity
(GO:0005096)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Intracellular signal transduction
(GO:0035556)
Membrane
(GO:0016020)
Positive regulation of axonogenesis
(GO:0050772)
Protein binding
(GO:0005515)
Signal transduction
(GO:0007165)
Small gtpase-mediated signal transduction
(GO:0007264)
Synapse
(GO:0045202)

Other Information

Proteins

SIF and TIAM1-like exchange factor

Genular Protein ID: 429310479

Symbol: TIAM2_MOUSE

Name: SIF and TIAM1-like exchange factor

UniProtKB Accession Codes:

Q6ZPF3 Q3TSM6 Q3TZ33 Q6AXF2 Q6NXJ2 Q9JLY2 Q9WVS3

Database IDs:

Citations:

PubMed ID: 10364228

Title: Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1.

PubMed ID: 10364228

DOI: 10.1074/jbc.274.25.17837

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10512681

Title: Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1.

PubMed ID: 10512681

DOI: 10.1006/geno.1999.5936

PubMed ID: 11707441

Title: Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.

PubMed ID: 11707441

DOI: 10.1074/jbc.m106186200

PubMed ID: 11900975

Title: Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain.

PubMed ID: 11900975

DOI: 10.1016/s0925-4773(01)00650-5

PubMed ID: 12912917

Title: The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.

PubMed ID: 12912917

DOI: 10.1093/emboj/cdg413

PubMed ID: 14550769

Title: Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.

PubMed ID: 14550769

DOI: 10.1016/s1044-7431(03)00122-2

PubMed ID: 17320046

Title: Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.

PubMed ID: 17320046

DOI: 10.1016/j.bbrc.2007.02.028

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19893486

Title: The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.

PubMed ID: 19893486

DOI: 10.1038/emboj.2009.323

Sequence Information:

Length: 1715
Mass: 192567
Checksum: 96C1E063BC6F36C0
Sequence:

MGNSESQYTF QGSKNHSNTV TGAKQKPCSL KIRSVHAKDE KSLHGWTHGS SGAGYKSRSL 
ARSCLSHFKN HQPYATRLSG PTCKVSKGTT YSKHRANTPG NDFQGNSGAF LPENGFHYVD 
RESEESHITS NGHLLTCYGR KESLASTPPG EDHRSPRVLI KTLGKLDGCL RVEFHNGGNP 
HKGTSEDPSG PVRLLRYSPT LASETCPVRE TRRHSAAGSP SSQRPSPTDS RLRSSKGSSL 
SSESSWYDSP WGNAGEVSEV EGSFLAPSTP DPSLPSSFPP SDTKKPFNQS SSLSSLRELY 
KDPNLGCRSP SGTCLSSNEY ISSQVSLNNR VSFASDMDVP SRVDHRDPLH YSSFTLPCRK 
SKALTEDAAK KDTLKARMRR FSDWTGSLSR KKRKLQEPRS MEGSEYFDSH SDGLNAEGQV 
PAQTSSLLWS GGSAQTLPHR SESTHAISVD PLRQNIYENF MRELEMSRSN TEHVETSTET 
MESSSESVSS LEQLDLLFEK EQGVVRKAGW LFFKPLVTLQ KERKLELVAR RKWKQYWVTL 
KGCTLLFYET YGKNSTEQNS APRCALFAED SIVQSVPEHP KKEHVFCLSN SCGDVYLFQA 
TSQTDLENWV TAIHSACASL FAKKHGKEDT VRLLKSQTRS LLQKIDMDSK MKKMAELQLS 
VVSDPKNRKA IENQIRQWEQ NLEKFHMDLF RMRCYLASLQ GGELPNPKSL LAATSRPSKL 
ALGRLGVLSV SSFHALVCSR DDSTLRKRTL SLTQRGKSKK GIFSSLKGLD TLARKGREKR 
ASITQMFDSS HSHGFLGTQL PQKSTNSNKA HDLHLYGSAV DSALRDSMWE VQTYVHFQDN 
EGVTVTIKPE HRVEDVLALV CKMRQLEPTH YGLQLRKVVD KSVEWCVPAL YEYMQEQVYD 
EIEVFPLSVY DVQLTKTGDM TDFGFAVTVQ VDEHQHLNRI FISDVLPDSL AYGGGLRKGN 
EITSLNGEPV SDLDIQQMEA LFSEKSVGLT LVARPVTTRR TLCASWSDSD LFSRDQKSLP 
PSPNQSQLLE EFLDNFRKTA TSDFSNVPEI TTGLKRSQTE GTLDQVPHRE KMEQTFLSAD 
QIAELCRDLN NTHTNSMEAP TESHDPPPRP LARHLSDADR LRKVIQELVD TEKSYVKDLS 
CLFELYLEPL QNETFLTQDE MESLFGSLPE MLEFQKVFLE TLEDAISASS DFSVLETPSQ 
FRKLLFSLGG SFLYYADHFK LYSGFCANHI KVQRVLERAK TDKAFKAFLD ARNPTKQHSS 
TLESYLIKPV QRVLKYPLLL KELVSLTDHE SEEHYHLTEA LKAMEKVASH INEMQKIYED 
YGMVFDQLVA EQSGTEKEVT ELSMGELLMH STVSWLNPFL SLGKARKDIE LTVFVFKRAV 
ILVYKENCKL KKKLPSNSRP AHNSADLDPF KFRWLIPISA LQVRLGNTAG TENNSTWELI 
HTKSEIEGRP ETIFQLCCSD SENKTSIVKV IRSILRENFR RHIKCELPLE KTCKDRLVPL 
KNRVPVSAKL ASSRSLKGLR TSSSSEWPSE PSKGNSLDSD ECSLSSGTQS SGCPVAESRR 
DSKSTELEKD AQEGLAEFPD GLIKESDILS DEDEDFHHPL KQGSPTKDIE IQFQRLKISE 
ESDVHPVGQQ PLTESGEQPK LVRGHFCPIK RKANSTKRGR GTLLKAQTRH QSLDSHPETA 
SIDLNLVLER EFSVQSLTSV VNEEGFYETQ SHGKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tiam2

Associated with

Other Information

Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. PubMed ID: 10364228

Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 14621295

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. PubMed ID: 10512681

Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth. PubMed ID: 11707441

Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain. PubMed ID: 11900975

The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration. PubMed ID: 12912917

Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology. PubMed ID: 14550769

Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. PubMed ID: 17320046

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module. PubMed ID: 19893486