Genular: Defining Cellular Identity and Function

Details for: Rnasel

Gene ID: 24014

Symbol: Rnasel

Ensembl ID: ENSMUSG00000066800

Description: ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Interferon alpha/beta signaling
(R-MMU-909733)
Interferon signaling
(R-MMU-913531)
Oas antiviral response
(R-MMU-8983711)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Defense response to virus
(GO:0051607)
Endonuclease activity
(GO:0004519)
Fat cell differentiation
(GO:0045444)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mrna processing
(GO:0006397)
Negative regulation of viral genome replication
(GO:0045071)
Nuclear matrix
(GO:0016363)
Nuclease activity
(GO:0004518)
Nucleotide binding
(GO:0000166)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Regulation of mrna stability
(GO:0043488)
Ribonucleoprotein complex binding
(GO:0043021)
Rna binding
(GO:0003723)
Rna nuclease activity
(GO:0004540)
Rna processing
(GO:0006396)
Rrna binding
(GO:0019843)
Rrna processing
(GO:0006364)

Other Information

Proteins

2-5A-dependent ribonuclease

Genular Protein ID: 3045900922

Symbol: RN5A_MOUSE

Name: 2-5A-dependent ribonuclease

UniProtKB Accession Codes:

Q05921 Q9ERU7

Database IDs:

Citations:

PubMed ID: 11063255

Title: Analysis and origins of the human and mouse RNase L genes: mediators of interferon action.

PubMed ID: 11063255

DOI: 10.1007/s003350010194

PubMed ID: 7680958

Title: Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action.

PubMed ID: 7680958

DOI: 10.1016/0092-8674(93)90403-d

PubMed ID: 11585831

Title: The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells.

PubMed ID: 11585831

DOI: 10.1074/jbc.m107482200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23825954

Title: Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L.

PubMed ID: 23825954

DOI: 10.1371/journal.ppat.1003474

PubMed ID: 29652922

Title: A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

PubMed ID: 29652922

DOI: 10.1371/journal.ppat.1006989

Sequence Information:

Length: 735
Mass: 83275
Checksum: B6632F4A5B50F711
Sequence:

METPDYNTPQ GGTPSAGSQR TVVEDDSSLI KAVQKGDVVR VQQLLEKGAD ANACEDTWGW 
TPLHNAVQAG RVDIVNLLLS HGADPHRRKK NGATPFIIAG IQGDVKLLEI LLSCGADVNE 
CDENGFTAFM EAAERGNAEA LRFLFAKGAN VNLRRQTTKD KRRLKQGGAT ALMSAAEKGH 
LEVLRILLND MKAEVDARDN MGRNALIRTL LNWDCENVEE ITSILIQHGA DVNVRGERGK 
TPLIAAVERK HTGLVQMLLS REGINIDARD NEGKTALLIA VDKQLKEIVQ LLLEKGADKC 
DDLVWIARRN HDYHLVKLLL PYVANPDTDP PAGDWSPHSS RWGTALKSLH SMTRPMIGKL 
KIFIHDDYKI AGTSEGAVYL GIYDNREVAV KVFRENSPRG CKEVSCLRDC GDHSNLVAFY 
GREDDKGCLY VCVSLCEWTL EEFLRLPREE PVENGEDKFA HSILLSIFEG VQKLHLHGYS 
HQDLQPQNIL IDSKKAVRLA DFDQSIRWMG ESQMVRRDLE DLGRLVLYVV MKGEIPFETL 
KTQNDEVLLT MSPDEETKDL IHCLFSPGEN VKNCLVDLLG HPFFWTWENR YRTLRNVGNE 
SDIKVRKCKS DLLRLLQHQT LEPPRSFDQW TSKIDKNVMD EMNHFYEKRK KNPYQDTVGD 
LLKFIRNIGE HINEEKKRGM KEILGDPSRY FQETFPDLVI YIYKKLKETE YRKHFPQPPP 
RLSVPEAVGP GGIQS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rnasel

Associated with

Other Information

Analysis and origins of the human and mouse RNase L genes: mediators of interferon action. PubMed ID: 11063255

Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. PubMed ID: 7680958

The 2-5A/RNase L/RNase L inhibitor (RNI) pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. PubMed ID: 11585831

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Evasion of Antiviral Innate Immunity by Theiler's Virus L* Protein through Direct Inhibition of RNase L. PubMed ID: 23825954