Details for: Sigirr

Gene ID: 24058

Symbol: Sigirr

Ensembl ID: ENSMUSG00000025494

Description: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Associated with

Other Information

Genular Protein ID: 1380999877

Symbol: SIGIR_MOUSE

Name: Single Ig IL-1-related receptor

UniProtKB Accession Codes:

Q9JLZ8 Q52L48

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 3 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 6 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 14993616

Title: Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family.

PubMed ID: 14993616

DOI: 10.1073/pnas.0308680101

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10346978

Title: Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily.

PubMed ID: 10346978

DOI: 10.1006/cyto.1998.0452

PubMed ID: 12925853

Title: SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.

PubMed ID: 12925853

DOI: 10.1038/ni968

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21077278

Title: Down-regulation of single immunoglobulin interleukin-1R-related molecule (SIGIRR)/TIR8 expression in intestinal epithelial cells during inflammation.

PubMed ID: 21077278

DOI: 10.1111/j.1365-2249.2010.04254.x

Sequence Information:

  • Length: 409
  • Mass: 46159
  • Checksum: 9D175DC27AAFBE18
  • Sequence:
    • MAGVCDMAPN FLSPSEDQAL GLALGREVAL NCTAWVFSRP QCPQPSVQWL KDGLALGNGS 
HFSLHEDFWV SANFSEIVSS VLVLNLTNAE DYGTFTCSVW NVSSHSFTLW RAGPAGHVAA 
VLASLLVLVV LLLVALLYVK CRLNMLLWYQ DTYGEVEMND GKLYDAYVSY SDCPEDRKFV 
NFILKPQLER RRGYKLFLED RDLLPRAEPS ADLLVNLSRC RRLIVVLSDA FLSRPWCSQS 
FREGLCRLLE LTRRPIFITF EGQRREPIHP ALRLLRQHRH LVTLVLWKPG SVTPSSDFWK 
ELQLALPRKV QYRPVEGDPQ TRLQDDKDPM LIVRGRAAQG RGMESELDPD PEGDLGVRGP 
VFGEPPTPLQ ETRICIGESH GSEMDVSDLG SRNYSARTDF YCLVSEDDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.