Genular: Defining Cellular Identity and Function

Details for: Spry1

Gene ID: 24063

Symbol: Spry1

Ensembl ID: ENSMUSG00000037211

Description: sprouty RTK signaling antagonist 1

Associated with

Egfr downregulation
(R-MMU-182971)
Signaling by egfr
(R-MMU-177929)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Animal organ development
(GO:0048513)
Bud elongation involved in lung branching
(GO:0060449)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Epithelial to mesenchymal transition involved in cardiac fibroblast development
(GO:0060940)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of mitotic spindle orientation
(GO:0000132)
Golgi apparatus
(GO:0005794)
Membrane
(GO:0016020)
Metanephros development
(GO:0001656)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of gtpase activity
(GO:0034260)
Negative regulation of lens fiber cell differentiation
(GO:1902747)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of neurotrophin trk receptor signaling pathway
(GO:0051387)
Negative regulation of ras protein signal transduction
(GO:0046580)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Nucleoplasm
(GO:0005654)
Organ induction
(GO:0001759)
Positive regulation of apoptotic process
(GO:0043065)
Protein binding
(GO:0005515)
Regulation of signal transduction
(GO:0009966)
Ureteric bud development
(GO:0001657)

Other Information

Proteins

Protein sprouty homolog 1

Genular Protein ID: 1765195607

Symbol: SPY1_MOUSE

Name: Protein sprouty homolog 1

UniProtKB Accession Codes:

Q9QXV9

Database IDs:

Citations:

PubMed ID: 10498682

Title: Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

PubMed ID: 10498682

DOI: 10.1242/dev.126.20.4465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16877379

Title: A functional interaction between sprouty proteins and caveolin-1.

PubMed ID: 16877379

DOI: 10.1074/jbc.m603921200

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 25576668

Title: Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.

PubMed ID: 25576668

DOI: 10.1016/j.exer.2015.01.001

PubMed ID: 29501879

Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.

PubMed ID: 29501879

DOI: 10.1016/j.exer.2018.02.025

Sequence Information:

Length: 313
Mass: 34004
Checksum: CD3C27F7022C0B99
Sequence:

MDSPSQHGSH TSLVVIQPPA VEGRQRLDYD RDTQPATILS LDQIKAIRGS NEYTEGPSVA 
RRPAPRTAPR PEKQERTHEI IPANVNSSYE HRPASHPGNA RGSVLSRSTS TGSAASSGSS 
SSVSSEQGLL GRSPPTRPIP GHRSDRVIRT QPKQLLVEDL KASLKEDPTQ HKFICEQCGK 
CKCGECTAPR ALPSCLACDR QCLCSAESMV EYGTCMCLVK GIFYHCSNDD DGGSYSDNPC 
SCSQSHCCSR YLCMGALSLC LPCLLCYPPA KGCLKLCRGC YDWTHRPGCR CRNSNTVYCK 
LESCPSRAQG KLS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Spry1

Associated with

Other Information

Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. PubMed ID: 10498682

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A functional interaction between sprouty proteins and caveolin-1. PubMed ID: 16877379

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. PubMed ID: 25576668