Genular: Defining Cellular Identity and Function

Details for: Spry2

Gene ID: 24064

Symbol: Spry2

Ensembl ID: ENSMUSG00000022114

Description: sprouty RTK signaling antagonist 2

Associated with

Egfr downregulation
(R-MMU-182971)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Signaling by egfr
(R-MMU-177929)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Spry regulation of fgf signaling
(R-MMU-1295596)
Actin cytoskeleton
(GO:0015629)
Animal organ development
(GO:0048513)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Bud elongation involved in lung branching
(GO:0060449)
Cell fate commitment
(GO:0045165)
Cell projection
(GO:0042995)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of mitotic spindle orientation
(GO:0000132)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Inner ear morphogenesis
(GO:0042472)
Lung development
(GO:0030324)
Lung growth
(GO:0060437)
Lung morphogenesis
(GO:0060425)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule cytoskeleton
(GO:0015630)
Microtubule end
(GO:1990752)
Molecular function inhibitor activity
(GO:0140678)
Multicellular organism development
(GO:0007275)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cell projection organization
(GO:0031345)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of gtpase activity
(GO:0034260)
Negative regulation of lens fiber cell differentiation
(GO:1902747)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of neurotrophin trk receptor signaling pathway
(GO:0051387)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of ras protein signal transduction
(GO:0046580)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Negative regulation of vascular endothelial growth factor signaling pathway
(GO:1900747)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of signal transduction
(GO:0009966)
Respiratory system development
(GO:0060541)
Sensory perception of sound
(GO:0007605)
Ubiquitin-protein transferase inhibitor activity
(GO:0055105)

Other Information

Proteins

Protein sprouty homolog 2

Genular Protein ID: 2997999441

Symbol: SPY2_MOUSE

Name: Protein sprouty homolog 2

UniProtKB Accession Codes:

Q9QXV8 Q9WUQ9

Database IDs:

Citations:

PubMed ID: 10498682

Title: Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

PubMed ID: 10498682

DOI: 10.1242/dev.126.20.4465

PubMed ID: 10074434

Title: Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis.

PubMed ID: 10074434

DOI: 10.1016/s0960-9822(99)80094-3

PubMed ID: 16877379

Title: A functional interaction between sprouty proteins and caveolin-1.

PubMed ID: 16877379

DOI: 10.1074/jbc.m603921200

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

PubMed ID: 25576668

Title: Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists.

PubMed ID: 25576668

DOI: 10.1016/j.exer.2015.01.001

PubMed ID: 29501879

Title: Negative regulation of lens fiber cell differentiation by RTK antagonists Spry and Spred.

PubMed ID: 29501879

DOI: 10.1016/j.exer.2018.02.025

Sequence Information:

Length: 315
Mass: 34623
Checksum: 81514698EAD809A7
Sequence:

MEARAQSGNG SQPLLQTAHD SGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT 
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQPSQVH SSRAPLSRSI STVSSGSRSS 
TRTSTSSSSS EQRLLGPSFS HGPAAADGII RVQPKSELKP GDVKPLSKDD LGLHAYRCED 
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN 
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC 
CKVPTVPPRN FEKPT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Spry2

Associated with

Other Information

Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. PubMed ID: 10498682

Conserved function of mSpry-2, a murine homolog of Drosophila sprouty, which negatively modulates respiratory organogenesis. PubMed ID: 10074434

A functional interaction between sprouty proteins and caveolin-1. PubMed ID: 16877379

Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. PubMed ID: 17974561

Negative regulation of TGFbeta-induced lens epithelial to mesenchymal transition (EMT) by RTK antagonists. PubMed ID: 25576668