Genular: Defining Cellular Identity and Function

Details for: Spry4

Gene ID: 24066

Symbol: Spry4

Ensembl ID: ENSMUSG00000024427

Description: sprouty RTK signaling antagonist 4

Associated with

Animal organ development
(GO:0048513)
Cell projection
(GO:0042995)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of ras protein signal transduction
(GO:0046580)
Negative regulation of substrate adhesion-dependent cell spreading
(GO:1900025)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein kinase inhibitor activity
(GO:0004860)
Regulation of signal transduction
(GO:0009966)

Other Information

Proteins

Protein sprouty homolog 4

Genular Protein ID: 2990756205

Symbol: SPY4_MOUSE

Name: Protein sprouty homolog 4

UniProtKB Accession Codes:

Q9WTP2 Q543R1 Q9QXV7

Database IDs:

Citations:

PubMed ID: 10330503

Title: Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo.

PubMed ID: 10330503

DOI: 10.1016/s0925-4773(98)00241-x

PubMed ID: 10498682

Title: Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed.

PubMed ID: 10498682

DOI: 10.1242/dev.126.20.4465

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16877379

Title: A functional interaction between sprouty proteins and caveolin-1.

PubMed ID: 16877379

DOI: 10.1074/jbc.m603921200

PubMed ID: 17974561

Title: Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.

PubMed ID: 17974561

DOI: 10.1074/jbc.m705457200

Sequence Information:

Length: 300
Mass: 32523
Checksum: DA963036EFC0E73F
Sequence:

MEPPVPQSSV PVNPSSVMVQ PLLDSRAPHS RLQHPLTILP IDQMKTSHVE NDYIDNPSLA 
PATGPKRPRG GPPELAPTPA RCDQDITHHW ISFSGRPSSV SSSSSTSSDQ RLLDHMAPPP 
VAEQASPRAV RLQPKVVHCK PLDLKGPTAP PELDKHFLLC EACGKCKCKE CASPRTLPSC 
WVCNQECLCS AQTLVNYGTC MCLVQGIFYH CTNEDDEGSC ADHPCSCSGS NCCARWSFMG 
ALSVVLPCLL CYLPATGCVK LAQRGYDRLR RPGCRCKHTN SVICKAASGD TKTSRSDKPF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Spry4

Associated with

Other Information

Cloning and expression pattern of a mouse homologue of Drosophila sprouty in the mouse embryo. PubMed ID: 10330503

Vertebrate sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. PubMed ID: 10498682

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A functional interaction between sprouty proteins and caveolin-1. PubMed ID: 16877379