Genular: Defining Cellular Identity and Function

Details for: Sufu

Gene ID: 24069

Symbol: Sufu

Ensembl ID: ENSMUSG00000025231

Description: SUFU negative regulator of hedgehog signaling

Associated with

Degradation of gli1 by the proteasome
(R-MMU-5610780)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Hedgehog 'off' state
(R-MMU-5610787)
Hedgehog 'on' state
(R-MMU-5632684)
Signaling by hedgehog
(R-MMU-5358351)
Signal transduction
(R-MMU-162582)
Aorta development
(GO:0035904)
Beta-catenin binding
(GO:0008013)
Cilium
(GO:0005929)
Coronary vasculature development
(GO:0060976)
Cytoplasm
(GO:0005737)
Cytoplasmic sequestering of transcription factor
(GO:0042994)
Cytosol
(GO:0005829)
Determination of left/right symmetry
(GO:0007368)
Gli-sufu complex
(GO:1990788)
Heart looping
(GO:0001947)
Multicellular organism development
(GO:0007275)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of ubiquitin-dependent protein catabolic process
(GO:2000059)
Neural tube closure
(GO:0001843)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Skin development
(GO:0043588)
Smoothened signaling pathway
(GO:0007224)
Smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
(GO:0021776)
Smoothened signaling pathway involved in ventral spinal cord interneuron specification
(GO:0021775)
Spinal cord dorsal/ventral patterning
(GO:0021513)
Transcription factor binding
(GO:0008134)
Ventricular septum development
(GO:0003281)

Other Information

Proteins

SUFU_MOUSE
Q3U0Z8_MOUSE

Genular Protein ID: 3962357586

Symbol: SUFU_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9Z0P7 Q8C8B4 Q99JG0 Q9D521 Q9JLU1

Database IDs:

Citations:

PubMed ID: 10531011

Title: Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1.

PubMed ID: 10531011

DOI: 10.1016/s0960-9822(99)80482-5

PubMed ID: 11252182

Title: Suppressor of fused gene involved in hedgehog signal transduction in Drosophila melanogaster is conserved in mammals.

PubMed ID: 11252182

DOI: 10.1007/s004270050255

PubMed ID: 11557033

Title: Genomic organization and embryonic expression of suppressor of fused, a candidate gene for the split-hand/split-foot malformation type 3.

PubMed ID: 11557033

DOI: 10.1016/s0014-5793(01)02682-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11477086

Title: Suppressor of fused negatively regulates beta-catenin signaling.

PubMed ID: 11477086

DOI: 10.1074/jbc.m105317200

PubMed ID: 11960000

Title: Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.

PubMed ID: 11960000

DOI: 10.1073/pnas.082096999

PubMed ID: 16155214

Title: Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused.

PubMed ID: 16155214

DOI: 10.1242/dev.02021

PubMed ID: 16459298

Title: Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

PubMed ID: 16459298

DOI: 10.1016/j.devcel.2005.12.013

PubMed ID: 19592253

Title: The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development.

PubMed ID: 19592253

DOI: 10.1016/j.cub.2009.06.046

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20360384

Title: The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins.

PubMed ID: 20360384

DOI: 10.1101/gad.1902910

PubMed ID: 23034632

Title: Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis.

PubMed ID: 23034632

DOI: 10.1242/dev.081190

Sequence Information:

Length: 484
Mass: 53957
Checksum: 6ED5666BC4D4AFB5
Sequence:

MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY 
WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL 
TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT 
EDPQMQPVRT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR 
GETIFEIDPH LQERVDKGIE TDGSNLSGVS AKCAWDDLSR PPEDEEDSRS ICLGTQPRRL 
SGKDTEQIRE TLRRGLEINS KPVLPPINSQ RQNGLTHDRA PSRKDSLGSD SSTAIIPHEL 
IRTRQLESVH LKFNQESGAL IPLCLRGRLL HGRHFTYKSI TGDMAITFVS TGVEGAFATE 
EHPYAAHGPW LQILLTEEFV EKMLEDLEDL TSPEEFKLPK EYSWPEKKLK VSILPDVVFD 
SPLH

Genular Protein ID: 608894083

Symbol: Q3U0Z8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U0Z8

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 485
Mass: 54085
Checksum: F9387714357EC8E4
Sequence:

MAELRPSVAP GPAAPPASGP SAPPAFASLF PPGLHAIYGE CRRLYPDQPN PLQVTAIVKY 
WLGGPDPLDY VSMYRNMGSP SANIPEHWHY ISFGLSDLYG DNRVHEFTGT DGPSGFGFEL 
TFRLKRETGE SAPPTWPAEL MQGLARYVFQ SENTFCSGDH VSWHSPLDNS ESRIQHMLLT 
EDPQMQPVRT PFGVVTFLQI VGVCTEELHS AQQWNGQGIL ELLRTVPIAG GPWLITDMRR 
GETIFEIDPH LQQERVDKGI ETDGSNLSGV SAKCAWDDLS RPPEDEEDSR SICLGTQPRR 
LSGKDTEQIR ETLRRGLEIN SKPVLPPINS QRQNGLTHDR APSRKDSLGS DSSTAIIPHE 
LIRTRQLESV HLKFNQESGA LIPLCLRGRL LHGRHFTYKS ITGDMAITFV STGVEGAFAT 
EEHPYAAHGP WLQILLTEEF VEKMLEDLED LTSPEEFKLP KEYSWPEKKL KVSILPDVVF 
DSPLH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sufu

Associated with

Other Information

Mouse suppressor of fused is a negative regulator of sonic hedgehog signaling and alters the subcellular distribution of Gli1. PubMed ID: 10531011

Suppressor of fused gene involved in hedgehog signal transduction in Drosophila melanogaster is conserved in mammals. PubMed ID: 11252182

Genomic organization and embryonic expression of suppressor of fused, a candidate gene for the split-hand/split-foot malformation type 3. PubMed ID: 11557033

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Suppressor of fused negatively regulates beta-catenin signaling. PubMed ID: 11477086

Suppressor of fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex. PubMed ID: 11960000

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused. PubMed ID: 16155214

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. PubMed ID: 16459298

The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. PubMed ID: 19592253

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. PubMed ID: 20360384

Kif7 regulates Gli2 through Sufu-dependent and -independent functions during skin development and tumorigenesis. PubMed ID: 23034632

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073