Genular: Defining Cellular Identity and Function

Details for: Tlr2

Gene ID: 24088

Symbol: Tlr2

Ensembl ID: ENSMUSG00000027995

Description: toll-like receptor 2

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Beta defensins
(R-MMU-1461957)
Defensins
(R-MMU-1461973)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Regulation of tlr by endogenous ligand
(R-MMU-5686938)
Toll-like receptor cascades
(R-MMU-168898)
Amyloid-beta binding
(GO:0001540)
Cell surface pattern recognition receptor signaling pathway
(GO:0002752)
Cellular response to bacterial lipopeptide
(GO:0071221)
Central nervous system myelin formation
(GO:0032289)
Chemokine production
(GO:0032602)
Defense response
(GO:0006952)
Defense response to gram-positive bacterium
(GO:0050830)
Detection of diacyl bacterial lipopeptide
(GO:0042496)
Detection of triacyl bacterial lipopeptide
(GO:0042495)
Diacyl lipopeptide binding
(GO:0042498)
Erk1 and erk2 cascade
(GO:0070371)
I-kappab phosphorylation
(GO:0007252)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Interleukin-6 production
(GO:0032635)
Interleukin-17 production
(GO:0032620)
Learning
(GO:0007612)
Leukocyte migration
(GO:0050900)
Leukotriene metabolic process
(GO:0006691)
Lipopeptide binding
(GO:0071723)
Lipopolysaccharide binding
(GO:0001530)
Lipoteichoic acid binding
(GO:0070891)
Macrophage cytokine production
(GO:0010934)
Microglia development
(GO:0014005)
Microglial cell activation
(GO:0001774)
Myd88-dependent toll-like receptor signaling pathway
(GO:0002755)
Negative regulation of actin filament polymerization
(GO:0030837)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of phagocytosis
(GO:0050765)
Negative regulation of synapse assembly
(GO:0051964)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide metabolic process
(GO:0046209)
Pattern recognition receptor activity
(GO:0038187)
Peptidoglycan binding
(GO:0042834)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of interleukin-18 production
(GO:0032741)
Positive regulation of leukocyte migration
(GO:0002687)
Positive regulation of macrophage cytokine production
(GO:0060907)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of oligodendrocyte differentiation
(GO:0048714)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of wnt signaling pathway
(GO:0030177)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of dendritic cell cytokine production
(GO:0002730)
Response to bacterial lipoprotein
(GO:0032493)
Response to bacterium
(GO:0009617)
Response to fatty acid
(GO:0070542)
Response to molecule of fungal origin
(GO:0002238)
Response to peptidoglycan
(GO:0032494)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Toll-like receptor 2 signaling pathway
(GO:0034134)
Toll-like receptor binding
(GO:0035325)
Toll-like receptor signaling pathway
(GO:0002224)
Toll-like receptor tlr6:tlr2 signaling pathway
(GO:0038124)
Transmembrane signaling receptor activity
(GO:0004888)
Triacyl lipopeptide binding
(GO:0042497)
Tumor necrosis factor production
(GO:0032640)

Other Information

Proteins

Toll-like receptor 2
G3X8Y8_MOUSE

Genular Protein ID: 927950322

Symbol: TLR2_MOUSE

Name: Toll-like receptor 2

UniProtKB Accession Codes:

Q9QUN7 Q3U400 Q9DBC4

Database IDs:

Citations:

PubMed ID: 10548109

Title: The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

PubMed ID: 10548109

DOI: 10.1038/44605

PubMed ID: 10358136

Title: Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin.

PubMed ID: 10358136

PubMed ID: 10666214

Title: Gene expressions of lipopolysaccharide receptors, Toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes.

PubMed ID: 10666214

PubMed ID: 10823826

Title: The lipopolysaccharide-activated Toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes.

PubMed ID: 10823826

DOI: 10.1074/jbc.m002137200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11095740

Title: The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors.

PubMed ID: 11095740

DOI: 10.1073/pnas.250476497

PubMed ID: 15690042

Title: CD36 is a sensor of diacylglycerides.

PubMed ID: 15690042

DOI: 10.1038/nature03253

PubMed ID: 17486091

Title: Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.

PubMed ID: 17486091

DOI: 10.1038/ni1468

PubMed ID: 25689444

Title: Corrigendum: Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages.

PubMed ID: 25689444

DOI: 10.1038/ni0315-326b

PubMed ID: 18780723

Title: A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors.

PubMed ID: 18780723

DOI: 10.1093/intimm/dxn098

PubMed ID: 19362712

Title: TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.

PubMed ID: 19362712

DOI: 10.1016/j.cellimm.2009.03.008

PubMed ID: 22665377

Title: Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages.

PubMed ID: 22665377

DOI: 10.1128/iai.00399-12

PubMed ID: 22174456

Title: Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2.

PubMed ID: 22174456

DOI: 10.4049/jimmunol.1102177

PubMed ID: 27220037

Title: LppM impact on the colonization of macrophages by Mycobacterium tuberculosis.

PubMed ID: 27220037

DOI: 10.1111/cmi.12619

PubMed ID: 27805901

Title: RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity.

PubMed ID: 27805901

DOI: 10.7554/elife.18496

PubMed ID: 17889651

Title: Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide.

PubMed ID: 17889651

DOI: 10.1016/j.cell.2007.09.008

PubMed ID: 19931471

Title: Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.

PubMed ID: 19931471

DOI: 10.1016/j.immuni.2009.09.018

PubMed ID: 26283364

Title: Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3).

PubMed ID: 26283364

DOI: 10.1073/pnas.1502026112

Sequence Information:

Length: 784
Mass: 89449
Checksum: 606D56BF85F320A2
Sequence:

MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL TAAMKSLDLS 
FNKITYIGHG DLRACANLQV LILKSSRINT IEGDAFYSLG SLEHLDLSDN HLSSLSSSWF 
GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN LQTLRIGNVE TFSEIRRIDF AGLTSLNELE 
IKALSLRNYQ SQSLKSIRDI HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS 
PLPVDEVSSP MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCSFSQHLK 
SLEFLDLSEN LMVEEYLKNS ACKGAWPSLQ TLVLSQNHLR SMQKTGEILL TLKNLTSLDI 
SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ 
ELYISRNKLK TLPDASLFPV LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE 
LLSFTMETPA LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ DSHWVENLMV 
QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV FVLSENFVRS EWCKYELDFS 
HFRLFDENND AAILVLLEPI ERKAIPQRFC KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT 
AIKS

Genular Protein ID: 1720631580

Symbol: G3X8Y8_MOUSE

Name: N/A

UniProtKB Accession Codes:

G3X8Y8

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 784
Mass: 89467
Checksum: BCBE96FCB988D858
Sequence:

MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL TAAMKSLDLS 
FNKITYIGHG DLRACANLQV LMLKSSRINT IEGDAFYSLG SLEHLDLSDN HLSSLSSSWF 
GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN LQTLRIGNVE TFSEIRRIDF AGLTSLNELE 
IKALSLRNYQ SQSLKSIRDI HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS 
PLPVDEVSSP MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCSFSQHLK 
SLEFLDLSEN LMVEEYLKNS ACKGAWPSLQ TLVLSQNHLR SMQKTGEILL TLKNLTSLDI 
SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ 
ELYISRNKLK TLPDASLFPV LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE 
LLSFTMETPA LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ DSHWVENLMV 
QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV FVLSENFVRS EWCKYELDFS 
HFRLFDENND AAILVLLEPI ERKAIPQRFC KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT 
AIKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tlr2

Associated with

Other Information

The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. PubMed ID: 10548109

Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin. PubMed ID: 10358136

Gene expressions of lipopolysaccharide receptors, Toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes. PubMed ID: 10666214

The lipopolysaccharide-activated Toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. PubMed ID: 10823826

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. PubMed ID: 11095740

CD36 is a sensor of diacylglycerides. PubMed ID: 15690042

Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. PubMed ID: 17486091

Corrigendum: Direct extracellular interaction between the early secreted antigen ESAT-6 of Mycobacterium tuberculosis and TLR2 inhibits TLR signaling in macrophages. PubMed ID: 25689444

A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors. PubMed ID: 18780723

TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. PubMed ID: 19362712

Staphylococcal superantigen-like protein 3 binds to the Toll-like receptor 2 extracellular domain and inhibits cytokine production induced by Staphylococcus aureus, cell wall component, or lipopeptides in murine macrophages. PubMed ID: 22665377

Recombinant MPT83 derived from Mycobacterium tuberculosis induces cytokine production and upregulates the function of mouse macrophages through TLR2. PubMed ID: 22174456

LppM impact on the colonization of macrophages by Mycobacterium tuberculosis. PubMed ID: 27220037

RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. PubMed ID: 27805901

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. PubMed ID: 17889651

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. PubMed ID: 19931471

Structural basis for inhibition of TLR2 by staphylococcal superantigen-like protein 3 (SSL3). PubMed ID: 26283364

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303