Details for: ALOX5AP
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 147.8348
Cell Significance Index: -23.0000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 95.8038
Cell Significance Index: -24.3000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 74.7802
Cell Significance Index: -30.3800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 61.2770
Cell Significance Index: -31.5200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 57.3897
Cell Significance Index: -27.1000 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 32.1238
Cell Significance Index: -30.6700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 18.5895
Cell Significance Index: -22.9200 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 18.1494
Cell Significance Index: 48.6200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 8.8460
Cell Significance Index: -27.1700 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 7.5902
Cell Significance Index: 31.5900 - Cell Name: centroblast (CL0009112)
Fold Change: 6.4679
Cell Significance Index: 15.0900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.2442
Cell Significance Index: -24.6400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 5.8423
Cell Significance Index: 90.3900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 4.6064
Cell Significance Index: 135.2900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.2234
Cell Significance Index: 219.9500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.0454
Cell Significance Index: 241.2200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.6440
Cell Significance Index: 30.3900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1537
Cell Significance Index: 187.6500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.0446
Cell Significance Index: 67.4000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9550
Cell Significance Index: 103.8800 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.7189
Cell Significance Index: 12.3500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4417
Cell Significance Index: 9.4100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3688
Cell Significance Index: 70.1800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3409
Cell Significance Index: 23.5800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2982
Cell Significance Index: 17.9100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0906
Cell Significance Index: 2.6100 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0700
Cell Significance Index: 7.1500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0484
Cell Significance Index: 1.3000 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.0376
Cell Significance Index: 0.5500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0080
Cell Significance Index: 0.2800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0070
Cell Significance Index: -5.2700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0097
Cell Significance Index: -18.2500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0159
Cell Significance Index: -11.7900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0162
Cell Significance Index: -10.1000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0164
Cell Significance Index: -30.2600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0190
Cell Significance Index: -29.2600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0217
Cell Significance Index: -29.5400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0291
Cell Significance Index: -16.4000 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0309
Cell Significance Index: -0.6700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0373
Cell Significance Index: -20.3500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0410
Cell Significance Index: -30.0300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0461
Cell Significance Index: -2.0900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0467
Cell Significance Index: -29.6900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0534
Cell Significance Index: -23.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0620
Cell Significance Index: -17.8400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0654
Cell Significance Index: -29.6800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0678
Cell Significance Index: -24.3400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0779
Cell Significance Index: -16.4000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0874
Cell Significance Index: -14.9200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0934
Cell Significance Index: -18.7300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.1016
Cell Significance Index: -20.1700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1165
Cell Significance Index: -21.0000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1457
Cell Significance Index: -7.3600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1540
Cell Significance Index: -2.3200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1615
Cell Significance Index: -22.1800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1777
Cell Significance Index: -7.2800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1923
Cell Significance Index: -27.9600 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1947
Cell Significance Index: -22.2300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1955
Cell Significance Index: -24.0400 - Cell Name: leukocyte (CL0000738)
Fold Change: -0.2073
Cell Significance Index: -3.5200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2143
Cell Significance Index: -24.9700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2177
Cell Significance Index: -28.1300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2272
Cell Significance Index: -23.6600 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.2297
Cell Significance Index: -3.9600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2395
Cell Significance Index: -30.7000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2400
Cell Significance Index: -11.2800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2584
Cell Significance Index: -29.6000 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -0.2632
Cell Significance Index: -1.4400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.2808
Cell Significance Index: -7.0200 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3293
Cell Significance Index: -14.3200 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3442
Cell Significance Index: -24.3400 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3645
Cell Significance Index: -27.9700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3777
Cell Significance Index: -28.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3850
Cell Significance Index: -12.3300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3908
Cell Significance Index: -26.2800 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3920
Cell Significance Index: -31.0500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4333
Cell Significance Index: -26.6300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4362
Cell Significance Index: -27.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.4459
Cell Significance Index: -27.3400 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.4832
Cell Significance Index: -3.9400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5045
Cell Significance Index: -28.3100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5071
Cell Significance Index: -26.3400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5299
Cell Significance Index: -14.1500 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: -0.5448
Cell Significance Index: -4.8000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5527
Cell Significance Index: -25.7700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5706
Cell Significance Index: -29.9600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5719
Cell Significance Index: -29.7900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5768
Cell Significance Index: -16.1200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6303
Cell Significance Index: -22.0800 - Cell Name: late promyelocyte (CL0002151)
Fold Change: -0.6406
Cell Significance Index: -4.2500 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6690
Cell Significance Index: -17.0900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6781
Cell Significance Index: -30.0000 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: -0.6960
Cell Significance Index: -8.8200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.6985
Cell Significance Index: -22.8700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7112
Cell Significance Index: -22.6500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.7216
Cell Significance Index: -26.4900 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: -0.7836
Cell Significance Index: -7.3300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.7925
Cell Significance Index: -30.0100 - Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: -0.8058
Cell Significance Index: -7.6400 - Cell Name: myeloid cell (CL0000763)
Fold Change: -0.8060
Cell Significance Index: -10.7100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4285660111
Symbol: AL5AP_HUMAN
Name: Arachidonate 5-lipoxygenase-activating protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2300173
Title: Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.
PubMed ID: 2300173
DOI: 10.1038/343282a0
PubMed ID: 1673682
Title: Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP).
PubMed ID: 1673682
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8440384
Title: 5-lipoxygenase-activating protein is an arachidonate binding protein.
PubMed ID: 8440384
PubMed ID: 8245774
Title: 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.
PubMed ID: 8245774
PubMed ID: 14770184
Title: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.
PubMed ID: 14770184
DOI: 10.1038/ng1311
PubMed ID: 17304054
Title: No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population.
PubMed ID: 17304054
PubMed ID: 19233132
Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.
PubMed ID: 19233132
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 17600184
Title: Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.
PubMed ID: 17600184
Sequence Information:
- Length: 161
- Mass: 18157
- Checksum: 2625F8081B9E1BAA
- Sequence:
MDQETVGNVV LLAIVTLISV VQNGFFAHKV EHESRTQNGR SFQRTGTLAF ERVYTANQNC VDAYPTFLAV LWSAGLLCSQ VPAAFAGLMY LFVRQKYFVG YLGERTQSTP GYIFGKRIIL FLFLMSVAGI FNYYLIFFFG SDFENYIKTI STTISPLLLI P
Genular Protein ID: 3523534267
Symbol: A0A087WW23_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 218
- Mass: 24208
- Checksum: 2777A03A09233785
- Sequence:
MLTFNHDAPW HTQKTLKTSE FGKSFGTLGH IGNISHQCWA GCAAGGRAVL SGEPEANMDQ ETVGNVVLLA IVTLISVVQN GFFAHKVEHE SRTQNGRSFQ RTGTLAFERV YTANQNCVDA YPTFLAVLWS AGLLCSQVPA AFAGLMYLFV RQKYFVGYLG ERTQSTPGYI FGKRIILFLF LMSVAGIFNY YLIFFFGSDF ENYIKTISTT ISPLLLIP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.