Details for: ALOX5AP

Gene ID: 241

Symbol: ALOX5AP

Ensembl ID: ENSG00000132965

Description: arachidonate 5-lipoxygenase activating protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 147.8348
    Cell Significance Index: -23.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 95.8038
    Cell Significance Index: -24.3000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.7802
    Cell Significance Index: -30.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 61.2770
    Cell Significance Index: -31.5200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 57.3897
    Cell Significance Index: -27.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.1238
    Cell Significance Index: -30.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.5895
    Cell Significance Index: -22.9200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 18.1494
    Cell Significance Index: 48.6200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.8460
    Cell Significance Index: -27.1700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 7.5902
    Cell Significance Index: 31.5900
  • Cell Name: centroblast (CL0009112)
    Fold Change: 6.4679
    Cell Significance Index: 15.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2442
    Cell Significance Index: -24.6400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.8423
    Cell Significance Index: 90.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.6064
    Cell Significance Index: 135.2900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2234
    Cell Significance Index: 219.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0454
    Cell Significance Index: 241.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.6440
    Cell Significance Index: 30.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1537
    Cell Significance Index: 187.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0446
    Cell Significance Index: 67.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9550
    Cell Significance Index: 103.8800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.7189
    Cell Significance Index: 12.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4417
    Cell Significance Index: 9.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3688
    Cell Significance Index: 70.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3409
    Cell Significance Index: 23.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2982
    Cell Significance Index: 17.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0906
    Cell Significance Index: 2.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0700
    Cell Significance Index: 7.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0484
    Cell Significance Index: 1.3000
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0376
    Cell Significance Index: 0.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0159
    Cell Significance Index: -11.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0162
    Cell Significance Index: -10.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0164
    Cell Significance Index: -30.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0190
    Cell Significance Index: -29.2600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0217
    Cell Significance Index: -29.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0291
    Cell Significance Index: -16.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0309
    Cell Significance Index: -0.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0373
    Cell Significance Index: -20.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0410
    Cell Significance Index: -30.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0461
    Cell Significance Index: -2.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0467
    Cell Significance Index: -29.6900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0534
    Cell Significance Index: -23.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0620
    Cell Significance Index: -17.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0654
    Cell Significance Index: -29.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0678
    Cell Significance Index: -24.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0779
    Cell Significance Index: -16.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0874
    Cell Significance Index: -14.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0934
    Cell Significance Index: -18.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1016
    Cell Significance Index: -20.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1165
    Cell Significance Index: -21.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1457
    Cell Significance Index: -7.3600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1540
    Cell Significance Index: -2.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1615
    Cell Significance Index: -22.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1777
    Cell Significance Index: -7.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1923
    Cell Significance Index: -27.9600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1947
    Cell Significance Index: -22.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1955
    Cell Significance Index: -24.0400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2073
    Cell Significance Index: -3.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2143
    Cell Significance Index: -24.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2177
    Cell Significance Index: -28.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2272
    Cell Significance Index: -23.6600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2297
    Cell Significance Index: -3.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2395
    Cell Significance Index: -30.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2400
    Cell Significance Index: -11.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2584
    Cell Significance Index: -29.6000
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2632
    Cell Significance Index: -1.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2808
    Cell Significance Index: -7.0200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3293
    Cell Significance Index: -14.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3442
    Cell Significance Index: -24.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3645
    Cell Significance Index: -27.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3777
    Cell Significance Index: -28.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3850
    Cell Significance Index: -12.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3908
    Cell Significance Index: -26.2800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3920
    Cell Significance Index: -31.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4333
    Cell Significance Index: -26.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4362
    Cell Significance Index: -27.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4459
    Cell Significance Index: -27.3400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4832
    Cell Significance Index: -3.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5045
    Cell Significance Index: -28.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5071
    Cell Significance Index: -26.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5299
    Cell Significance Index: -14.1500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.5448
    Cell Significance Index: -4.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5527
    Cell Significance Index: -25.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5706
    Cell Significance Index: -29.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5719
    Cell Significance Index: -29.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5768
    Cell Significance Index: -16.1200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6303
    Cell Significance Index: -22.0800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.6406
    Cell Significance Index: -4.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6690
    Cell Significance Index: -17.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6781
    Cell Significance Index: -30.0000
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.6960
    Cell Significance Index: -8.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6985
    Cell Significance Index: -22.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7112
    Cell Significance Index: -22.6500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7216
    Cell Significance Index: -26.4900
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.7836
    Cell Significance Index: -7.3300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7925
    Cell Significance Index: -30.0100
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.8058
    Cell Significance Index: -7.6400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.8060
    Cell Significance Index: -10.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ALOX5AP is a protein with several key characteristics that make it an important player in the immune system. Some of these characteristics include: 1. **Enzyme activator**: ALOX5AP acts as an enzyme activator, increasing the activity of 5-lipoxygenase, which is essential for the synthesis of leukotrienes. 2. **Cell-type specific expression**: ALOX5AP is expressed in various cell types, including immune cells, such as basophils, T cells, and macrophages, which suggests that it plays a role in specific immune responses. 3. **Involvement in inflammatory responses**: Leukotrienes synthesized through the 5-lipoxygenase pathway, with the help of ALOX5AP, are known to mediate inflammatory responses, including those involved in asthma, allergy, and autoimmune diseases. 4. **Regulation of cellular processes**: ALOX5AP is involved in the regulation of various cellular processes, including cellular oxidant detoxification, glutathione peroxidase activity, and glutathione transferase activity. **Pathways and Functions** ALOX5AP is involved in several pathways and functions, including: 1. **Arachidonate 5-lipoxygenase activity**: ALOX5AP acts as an enzyme activator, increasing the activity of 5-lipoxygenase, which is essential for the synthesis of leukotrienes. 2. **Arachidonic acid binding**: ALOX5AP binds to arachidonic acid, facilitating its conversion into leukotriene A4. 3. **Biosynthesis of specialized proresolving mediators (spms)**: ALOX5AP is involved in the biosynthesis of spms, which are specialized proresolving mediators that play a role in resolving inflammation. 4. **Cellular response to calcium ion**: ALOX5AP is involved in the regulation of cellular responses to calcium ions, which is essential for the activation of various cellular processes. **Clinical Significance** ALOX5AP has significant clinical implications, particularly in the context of inflammatory diseases. Some of the clinical significance of ALOX5AP includes: 1. **Asthma**: Leukotrienes synthesized through the 5-lipoxygenase pathway, with the help of ALOX5AP, are known to mediate asthma, a common chronic respiratory disease. 2. **Allergy**: ALOX5AP is involved in the regulation of allergic responses, including those involved in atopic dermatitis, rhinitis, and allergic asthma. 3. **Autoimmune diseases**: Leukotrienes synthesized through the 5-lipoxygenase pathway, with the help of ALOX5AP, are known to mediate autoimmune responses, including those involved in rheumatoid arthritis, lupus, and multiple sclerosis. 4. **Cancer**: ALOX5AP is involved in the regulation of cancer-related inflammation, including the promotion of tumor growth and metastasis. In conclusion, ALOX5AP is a critical protein involved in the regulation of inflammatory responses, and its dysregulation has significant clinical implications in various diseases, including asthma, allergy, autoimmune diseases, and cancer. Further research is needed to fully understand the mechanisms of ALOX5AP and its potential therapeutic applications.

Genular Protein ID: 4285660111

Symbol: AL5AP_HUMAN

Name: Arachidonate 5-lipoxygenase-activating protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2300173

Title: Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.

PubMed ID: 2300173

DOI: 10.1038/343282a0

PubMed ID: 1673682

Title: Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP).

PubMed ID: 1673682

DOI: 10.1016/s0021-9258(18)93004-8

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8440384

Title: 5-lipoxygenase-activating protein is an arachidonate binding protein.

PubMed ID: 8440384

DOI: 10.1016/0014-5793(93)80528-3

PubMed ID: 8245774

Title: 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

PubMed ID: 8245774

DOI: 10.1084/jem.178.6.1935

PubMed ID: 14770184

Title: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.

PubMed ID: 14770184

DOI: 10.1038/ng1311

PubMed ID: 17304054

Title: No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population.

PubMed ID: 17304054

DOI: 10.1097/gim.0b013e318030c9c5

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17600184

Title: Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.

PubMed ID: 17600184

DOI: 10.1126/science.1144346

Sequence Information:

  • Length: 161
  • Mass: 18157
  • Checksum: 2625F8081B9E1BAA
  • Sequence:
  • MDQETVGNVV LLAIVTLISV VQNGFFAHKV EHESRTQNGR SFQRTGTLAF ERVYTANQNC 
    VDAYPTFLAV LWSAGLLCSQ VPAAFAGLMY LFVRQKYFVG YLGERTQSTP GYIFGKRIIL 
    FLFLMSVAGI FNYYLIFFFG SDFENYIKTI STTISPLLLI P

Genular Protein ID: 3523534267

Symbol: A0A087WW23_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 218
  • Mass: 24208
  • Checksum: 2777A03A09233785
  • Sequence:
  • MLTFNHDAPW HTQKTLKTSE FGKSFGTLGH IGNISHQCWA GCAAGGRAVL SGEPEANMDQ 
    ETVGNVVLLA IVTLISVVQN GFFAHKVEHE SRTQNGRSFQ RTGTLAFERV YTANQNCVDA 
    YPTFLAVLWS AGLLCSQVPA AFAGLMYLFV RQKYFVGYLG ERTQSTPGYI FGKRIILFLF 
    LMSVAGIFNY YLIFFFGSDF ENYIKTISTT ISPLLLIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.