Details for: ALOX5AP

Gene ID: 241

Symbol: ALOX5AP

Ensembl ID: ENSG00000132965

Description: arachidonate 5-lipoxygenase activating protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basophil (CL0000767)
    Fold Change: 3.42
    Marker Score: 1623
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.41
    Marker Score: 33749
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.23
    Marker Score: 3586
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.03
    Marker Score: 3466
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.97
    Marker Score: 76183
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.82
    Marker Score: 8227
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.81
    Marker Score: 1650
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.78
    Marker Score: 8779
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.75
    Marker Score: 1121
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.73
    Marker Score: 1984
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.45
    Marker Score: 2178
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.41
    Marker Score: 14672
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.38
    Marker Score: 1223.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.36
    Marker Score: 4109
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.33
    Marker Score: 1420
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.25
    Marker Score: 495
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.21
    Marker Score: 6198
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.15
    Marker Score: 13736
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.12
    Marker Score: 1166
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.11
    Marker Score: 5479
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.09
    Marker Score: 24297
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.08
    Marker Score: 930.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.07
    Marker Score: 1019
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.02
    Marker Score: 621
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.01
    Marker Score: 8598
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.99
    Marker Score: 5493
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.97
    Marker Score: 5840
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.87
    Marker Score: 802
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.85
    Marker Score: 2621
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.82
    Marker Score: 1536
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.79
    Marker Score: 555
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.71
    Marker Score: 1602
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.71
    Marker Score: 4252
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.7
    Marker Score: 939
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.64
    Marker Score: 943
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.64
    Marker Score: 91612
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.63
    Marker Score: 3185
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 1.62
    Marker Score: 3656
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.58
    Marker Score: 1337.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.57
    Marker Score: 679
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.56
    Marker Score: 1367.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.54
    Marker Score: 2644
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.54
    Marker Score: 1128
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.52
    Marker Score: 3698.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.49
    Marker Score: 1328
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.48
    Marker Score: 908
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.47
    Marker Score: 77938
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167265
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.45
    Marker Score: 368.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.45
    Marker Score: 933
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.45
    Marker Score: 470
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.42
    Marker Score: 327
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.38
    Marker Score: 1147
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.38
    Marker Score: 1665
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.38
    Marker Score: 1481
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.37
    Marker Score: 590
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.35
    Marker Score: 5587
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.34
    Marker Score: 353
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.3
    Marker Score: 981
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.29
    Marker Score: 1249.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.26
    Marker Score: 846
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.24
    Marker Score: 1495
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.24
    Marker Score: 439
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.23
    Marker Score: 894.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.23
    Marker Score: 2002
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.23
    Marker Score: 2326
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.23
    Marker Score: 1324
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.22
    Marker Score: 1443
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.22
    Marker Score: 716
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 1.21
    Marker Score: 939
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 1.21
    Marker Score: 1569
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.19
    Marker Score: 1121
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.19
    Marker Score: 725
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.19
    Marker Score: 282
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.17
    Marker Score: 849
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.16
    Marker Score: 767
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.15
    Marker Score: 11630
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.13
    Marker Score: 2020.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4732
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.12
    Marker Score: 254
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 670
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.11
    Marker Score: 252
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.11
    Marker Score: 553
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.09
    Marker Score: 1505
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.08
    Marker Score: 1973
  • Cell Name: mast cell (CL0000097)
    Fold Change: 1.05
    Marker Score: 611
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.05
    Marker Score: 1169
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.04
    Marker Score: 1050
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.04
    Marker Score: 264
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.04
    Marker Score: 1525
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.03
    Marker Score: 810
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.03
    Marker Score: 554
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.03
    Marker Score: 1045
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.02
    Marker Score: 617
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.02
    Marker Score: 368
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.02
    Marker Score: 351
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.01
    Marker Score: 964
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 682
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1
    Marker Score: 1109
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 1
    Marker Score: 883

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Other Information

**Key characteristics:** - It is a protein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is expressed in both the nucleus and cytoplasm. - It is a key regulator of inflammation and immune responses. **Pathways and functions:** - AL5AP is involved in the regulation of arachidonic acid metabolism, a process involved in the production of proresolving mediators (spms). - It also plays a role in the regulation of leukotriene production, which are signaling molecules involved in inflammation. - It is involved in the regulation of acute inflammatory response and tissue repair. **Clinical significance:** - Mutations in the ALOX5AP gene have been linked to several inflammatory diseases, including rheumatoid arthritis, asthma, and inflammatory bowel disease. - Targeting AL5AP has been explored as a therapeutic strategy for these diseases. **Additional points:** - AL5AP is a highly conserved protein, with similar sequences found in mammals, birds, and insects. - It is a potential therapeutic target for inflammatory diseases. - Further research is needed to understand the role of AL5AP in inflammation and to develop novel therapeutic strategies.

Genular Protein ID: 4285660111

Symbol: AL5AP_HUMAN

Name: Arachidonate 5-lipoxygenase-activating protein

UniProtKB Accession Codes:

P20292 Q5VV04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EMBL 8 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2300173

Title: Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.

PubMed ID: 2300173

DOI: 10.1038/343282a0

PubMed ID: 1673682

Title: Gene characterization and promoter analysis of the human 5-lipoxygenase-activating protein (FLAP).

PubMed ID: 1673682

DOI: 10.1016/s0021-9258(18)93004-8

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8440384

Title: 5-lipoxygenase-activating protein is an arachidonate binding protein.

PubMed ID: 8440384

DOI: 10.1016/0014-5793(93)80528-3

PubMed ID: 8245774

Title: 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes.

PubMed ID: 8245774

DOI: 10.1084/jem.178.6.1935

PubMed ID: 14770184

Title: The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.

PubMed ID: 14770184

DOI: 10.1038/ng1311

PubMed ID: 17304054

Title: No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population.

PubMed ID: 17304054

DOI: 10.1097/gim.0b013e318030c9c5

PubMed ID: 19233132

Title: Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein.

PubMed ID: 19233132

DOI: 10.1016/j.bbrc.2009.02.074

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 17600184

Title: Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein.

PubMed ID: 17600184

DOI: 10.1126/science.1144346

Sequence Information:

  • Length: 161
  • Mass: 18157
  • Checksum: 2625F8081B9E1BAA
  • Sequence:
    • MDQETVGNVV LLAIVTLISV VQNGFFAHKV EHESRTQNGR SFQRTGTLAF ERVYTANQNC 
VDAYPTFLAV LWSAGLLCSQ VPAAFAGLMY LFVRQKYFVG YLGERTQSTP GYIFGKRIIL 
FLFLMSVAGI FNYYLIFFFG SDFENYIKTI STTISPLLLI P

Genular Protein ID: 3523534267

Symbol: A0A087WW23_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WW23

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 218
  • Mass: 24208
  • Checksum: 2777A03A09233785
  • Sequence:
    • MLTFNHDAPW HTQKTLKTSE FGKSFGTLGH IGNISHQCWA GCAAGGRAVL SGEPEANMDQ 
ETVGNVVLLA IVTLISVVQN GFFAHKVEHE SRTQNGRSFQ RTGTLAFERV YTANQNCVDA 
YPTFLAVLWS AGLLCSQVPA AFAGLMYLFV RQKYFVGYLG ERTQSTPGYI FGKRIILFLF 
LMSVAGIFNY YLIFFFGSDF ENYIKTISTT ISPLLLIP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.