Genular: Defining Cellular Identity and Function

Details for: Usp18

Gene ID: 24110

Symbol: Usp18

Ensembl ID: ENSMUSG00000030107

Description: ubiquitin specific peptidase 18

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cytokine signaling in immune system
(R-MMU-1280215)
Deubiquitination
(R-MMU-5688426)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon alpha/beta signaling
(R-MMU-909733)
Interferon signaling
(R-MMU-913531)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Isg15 antiviral mechanism
(R-MMU-1169408)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Post-translational protein modification
(R-MMU-597592)
Regulation of ifna/ifnb signaling
(R-MMU-912694)
Regulation of nf-kappa b signaling
(R-MMU-9758274)
Signaling by interleukins
(R-MMU-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type peptidase activity
(GO:0008234)
Cytosol
(GO:0005829)
Hydrolase activity
(GO:0016787)
Intracellular membrane-bounded organelle
(GO:0043231)
Isg15-specific peptidase activity
(GO:0019785)
Molecular adaptor activity
(GO:0060090)
Nucleus
(GO:0005634)
Peptidase activity
(GO:0008233)
Protein binding
(GO:0005515)
Protein deubiquitination
(GO:0016579)
Proteolysis
(GO:0006508)
Response to bacterium
(GO:0009617)
Response to stilbenoid
(GO:0035634)

Other Information

Proteins

Ubl carboxyl-terminal hydrolase 18
Q3UAR6_MOUSE

Genular Protein ID: 3908961199

Symbol: UBP18_MOUSE

Name: Ubl carboxyl-terminal hydrolase 18

UniProtKB Accession Codes:

Q9WTV6 Q3U7P3

Database IDs:

Citations:

PubMed ID: 10082570

Title: A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation.

PubMed ID: 10082570

DOI: 10.1128/mcb.19.4.3029

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11788588

Title: UBP43 (USP18) specifically removes ISG15 from conjugated proteins.

PubMed ID: 11788588

DOI: 10.1074/jbc.m109078200

Sequence Information:

Length: 368
Mass: 42472
Checksum: 19A4458FEB44CC22
Sequence:

MGKGFGLLRK PCQSVVAEPQ QYSALEEERT MKRKRVLSRD LCSAWDSPHG LVGLHNIGQT 
CCLNSLLQVF MMNMDFRMIL KRITVPRSAE ERKRSVPFQL LLLLEKMQDS RQKAVLPTEL 
VQCLQKYNVP LFVQHDAAQL YLTIWNLTKD QITDTDLTER LQGLFTIWTQ ESLICVGCTA 
ESSRRSKLLT LSLPLFDKDA KPLKTLEDAL RCFVQPKELA SSDMCCESCG EKTPWKQVLK 
LTHLPQTLTI HLMRFSARNS RTEKICHSVN FPQSLDFSQV LPTEEDLGDT KEQSEIHYEL 
FAVIAHVGMA DFGHYCAYIR NPVDGKWFCF NDSHVCWVTW KDVQCTYGNH RYRWRETAYL 
LVYTKTGS

Genular Protein ID: 1197963107

Symbol: Q3UAR6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UAR6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 368
Mass: 42474
Checksum: 75A4419CD605CC2E
Sequence:

MGKGFGLLRK PCQSVVAEPQ QYSALEEERT MKRKRVLSRD LCSAWDSPHG LVGLHNIGQT 
CCLNSLLQVF MMNMDFRMIL KRITVPRSAE ERKRSVPFQL LLLLEKMQDS RQKAVLLTEL 
VQCLQKYNVP LFVQHDAAQL YLTIWNLTKD QITDTDLTER LQGLFTIWTQ ESLICVGCTA 
ESSRRSKLLT LSLPLFDKDA KPLKTLEDAL RCFVQPKELA SSDMCCESCG EKTPWKQVLK 
LTHLPQTLTI HLMRFSARNS RTEKICHSVN FPQSLDFSQV LPTEEDLGDT KEQSEIHYEL 
FAVIAHVGMA DFGHYCAYIR NPVDGNWFCF NDSHVCWVTW KDVQCTYGNH RYRWRETAYL 
LVYTKTGS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Usp18

Associated with

Other Information

A novel ubiquitin-specific protease, UBP43, cloned from leukemia fusion protein AML1-ETO-expressing mice, functions in hematopoietic cell differentiation. PubMed ID: 10082570

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

UBP43 (USP18) specifically removes ISG15 from conjugated proteins. PubMed ID: 11788588

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073