KIF4A | ENSG00000090889 | NCBI 24137

Details for: KIF4A

Gene ID: 24137

Symbol: KIF4A

Ensembl ID: ENSG00000090889

Description: kinesin family member 4A

Associated with

Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Developmental biology
(R-HSA-1266738)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Nervous system development
(R-HSA-9675108)
Recycling pathway of l1
(R-HSA-437239)
Vesicle-mediated transport
(R-HSA-5653656)
Anterograde axonal transport
(GO:0008089)
Atp binding
(GO:0005524)
Axon cytoplasm
(GO:1904115)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Iron-sulfur cluster binding
(GO:0051536)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Microtubule associated complex
(GO:0005875)
Microtubule binding
(GO:0008017)
Microtubule motor activity
(GO:0003777)
Midbody
(GO:0030496)
Mitotic cytokinesis
(GO:0000281)
Mitotic spindle midzone assembly
(GO:0051256)
Mitotic spindle organization
(GO:0007052)
Nuclear matrix
(GO:0016363)
Nucleoplasm
(GO:0005654)
Organelle organization
(GO:0006996)
Protein binding
(GO:0005515)
Spindle elongation
(GO:0051231)
Spindle microtubule
(GO:0005876)

Other Information

Proteins

Chromosome-associated kinesin KIF4A
Q59HG1_HUMAN

Genular Protein ID: 3567494722

Symbol: KIF4A_HUMAN

Name: Chromosome-associated kinesin KIF4A

UniProtKB Accession Codes:

O95239 B2R7V5 D3DVU4 Q86TN3 Q86XX7 Q9NNY6 Q9NY24 Q9UMW3

Database IDs:

Citations:

PubMed ID: 10978527

Title: Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein.

PubMed ID: 10978527

DOI: 10.1016/s0167-4781(00)00151-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9168136

Title: Increased chromokinesin immunoreactivity in retinoblastoma cells.

PubMed ID: 9168136

DOI: 10.1016/s0378-1119(96)00860-8

PubMed ID: 11736643

Title: Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis.

PubMed ID: 11736643

DOI: 10.1042/0264-6021:3600549

PubMed ID: 15297875

Title: Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.

PubMed ID: 15297875

DOI: 10.1038/sj.emboj.7600347

PubMed ID: 15625105

Title: Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis.

PubMed ID: 15625105

DOI: 10.1073/pnas.0408438102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24812067

Title: Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function.

PubMed ID: 24812067

DOI: 10.1136/jmedgenet-2013-102182

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29848660

Title: Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis.

PubMed ID: 29848660

DOI: 10.1242/jcs.211433

Sequence Information:

Length: 1232
Mass: 139881
Checksum: AD1B7C2A10AB24DB
Sequence:

MKEEVKGIPV RVALRCRPLV PKEISEGCQM CLSFVPGEPQ VVVGTDKSFT YDFVFDPSTE 
QEEVFNTAVA PLIKGVFKGY NATVLAYGQT GSGKTYSMGG AYTAEQENEP TVGVIPRVIQ 
LLFKEIDKKS DFEFTLKVSY LEIYNEEILD LLCPSREKAQ INIREDPKEG IKIVGLTEKT 
VLVALDTVSC LEQGNNSRTV ASTAMNSQSS RSHAIFTISL EQRKKSDKNS SFRSKLHLVD 
LAGSERQKKT KAEGDRLKEG ININRGLLCL GNVISALGDD KKGGFVPYRD SKLTRLLQDS 
LGGNSHTLMI ACVSPADSNL EETLNTLRYA DRARKIKNKP IVNIDPQTAE LNHLKQQVQQ 
LQVLLLQAHG GTLPGSITVE PSENLQSLME KNQSLVEENE KLSRGLSEAA GQTAQMLERI 
ILTEQANEKM NAKLEELRQH AACKLDLQKL VETLEDQELK ENVEIICNLQ QLITQLSDET 
VACMAAAIDT AVEQEAQVET SPETSRSSDA FTTQHALRQA QMSKELVELN KALALKEALA 
RKMTQNDSQL QPIQYQYQDN IKELELEVIN LQKEKEELVL ELQTAKKDAN QAKLSERRRK 
RLQELEGQIA DLKKKLNEQS KLLKLKESTE RTVSKLNQEI RMMKNQRVQL MRQMKEDAEK 
FRQWKQKKDK EVIQLKERDR KRQYELLKLE RNFQKQSNVL RRKTEEAAAA NKRLKDALQK 
QREVADKRKE TQSRGMEGTA ARVKNWLGNE IEVMVSTEEA KRHLNDLLED RKILAQDVAQ 
LKEKKESGEN PPPKLRRRTF SLTEVRGQVS ESEDSITKQI ESLETEMEFR SAQIADLQQK 
LLDAESEDRP KQRWENIATI LEAKCALKYL IGELVSSKIQ VSKLESSLKQ SKTSCADMQK 
MLFEERNHFA EIETELQAEL VRMEQQHQEK VLYLLSQLQQ SQMAEKQLEE SVSEKEQQLL 
STLKCQDEEL EKMREVCEQN QQLLRENEII KQKLTLLQVA SRQKHLPKDT LLSPDSSFEY 
VPPKPKPSRV KEKFLEQSMD IEDLKYCSEH SVNEHEDGDG DDDEGDDEEW KPTKLVKVSR 
KNIQGCSCKG WCGNKQCGCR KQKSDCGVDC CCDPTKCRNR QQGKDSLGTV ERTQDSEGSF 
KLEDPTEVTP GLSFFNPVCA TPNSKILKEM CDVEQVLSKK TPPAPSPFDL PELKHVATEY 
QENKAPGKKK KRALASNTSF FSGCSPIEEE AH

Genular Protein ID: 2763708203

Symbol: Q59HG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59HG1

Database IDs:

Sequence Information:

Length: 1235
Mass: 140339
Checksum: D9D236876A5C3218
Sequence:

DRIMKEEVKG IPVRVALRCR PLVPKEISEG CQMCLSFVPG EPQVVVGTDK SFTYDFVFDP 
STEQEEVFNT AVAPLIKGVF KGYNATVLAY GQTGSGKTYS MGGAYTAEQE NEPTVGVIPR 
VIQLLFKEID KKSDFEFTLK VSYLEIYNEE ILDLLCPSRE KAQINIREDP KEGIKIVGLT 
EKTVLVALDT VSCLEQGNNS RTVASTAMNS QSSRSHAIFT ISLEQRKKSD KNSSFRSKLH 
LVDLAGSERQ KKTKAEGDRL KEGININRGL LCLGNVISAL GDDKKGGFVP YRDSKLTRLL 
QDSLGGNSHT LMIACVSPAD SNLEETLNTL RYADRARKIK NKPIVNIDPQ TAELNHLKQQ 
VQQLQVLLLQ AHGGTLPGSI TVEPSENLQS LMEKNQSLVE ENEKLSRGLS EAAGQTAQML 
ERIIWTEQAN EKMNAKLEEL RQHAACKLDL QKLVETLEDQ ELKENVEIIC NLQQLITQLS 
DETVACMAAA IDTAVEQEAQ VETSPETSRS SDAFTTQHAL RQAQMSKELV ELNKALALKE 
ALARKMTQND SQLQPIQYQY QDNIKELELE VINLQKEKEE LVLELQTAKK DANQAKLSER 
RRKRLQELEG QIADLKKKLN EQSKLLKLKE STERTVSKLN QEIRMMKNQR VQLMRQMKED 
AEKFRQWKQK KDKEVIQLKE RDRKRQYELL KLERNFQKQS NVLRRKTEEA AAANKRLKDA 
LQKQREVADK RKETQSRGME GTAARVKNWL GNEIEVMVST EEAKRHLNDL LEDRKILAQD 
VAQLKEKKES GENPPPKLRR RTFSLTEVRG QVSESEDSIT KQIESLETEM EFRSAQIADL 
QQKLLDAESE DRPKQRWENI ATILEAKCAL KYLIGELVSS KIQVSKLESS LKQSKTSCAD 
MQKMLFEERN HFAEIETELQ AELVRMEQQH QEKVLYLLSQ LQQSQMAEKQ LEESVSEKEQ 
QLLSTLKCQD EELEKMREVC EQNQQLLREN EIIKQKLTLL QVASRQKHLP KDTLLSPDSS 
FEYVPPKPKP SRVKEKFLEQ SMDIEDLKYC SEHSVNEHED GDGDDDEGDD EEWKPTKLVK 
VSRKNIQGCS CKGWCGNKQC GCRKQKSDCG VDCCCDPTKC RNRQQGKDSL GTVERTQDSE 
GSFKLEDPTE VTPGLSFFNP VCATPNSKIL KEMCDVEQVL SKKTPPAPSP FDLPELKHVA 
TEYQENKAPG KKKKRALASN TSFFSGCSPI EEEAH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: KIF4A

Associated with

Other Information

Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein. PubMed ID: 10978527

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of the human X chromosome. PubMed ID: 15772651

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Increased chromokinesin immunoreactivity in retinoblastoma cells. PubMed ID: 9168136

Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis. PubMed ID: 11736643

Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. PubMed ID: 15297875

Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. PubMed ID: 15625105

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography. PubMed ID: 18318008

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Involvement of the kinesin family members KIF4A and KIF5C in intellectual disability and synaptic function. PubMed ID: 24812067

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Fe-S cluster coordination of the chromokinesin KIF4A alters its subcellular localization during mitosis. PubMed ID: 29848660