Details for: IFIT5

Gene ID: 24138

Symbol: IFIT5

Ensembl ID: ENSG00000152778

Description: interferon induced protein with tetratricopeptide repeats 5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.7
    Marker Score: 6,598
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.65
    Marker Score: 1,320
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,754
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,979
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 483
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,715
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,255
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,915
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 309
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.81
    Marker Score: 796
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,260
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.74
    Marker Score: 1,297
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 642
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.7
    Marker Score: 1,427
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.7
    Marker Score: 1,713
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,867
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.63
    Marker Score: 629
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9,883
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.61
    Marker Score: 293
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.6
    Marker Score: 668
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.58
    Marker Score: 1,032
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.57
    Marker Score: 388
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.57
    Marker Score: 1,333
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.56
    Marker Score: 582
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.55
    Marker Score: 289
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 433
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.54
    Marker Score: 13,858
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.54
    Marker Score: 2,329
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.53
    Marker Score: 1,088
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.53
    Marker Score: 1,002
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.52
    Marker Score: 355
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.52
    Marker Score: 211
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.52
    Marker Score: 6,066
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.52
    Marker Score: 119
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.51
    Marker Score: 739
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 208
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.51
    Marker Score: 122
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.5
    Marker Score: 363
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.5
    Marker Score: 2,079
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.5
    Marker Score: 123
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.5
    Marker Score: 283
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5
    Marker Score: 5,117
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 327
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.49
    Marker Score: 383
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.48
    Marker Score: 585
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.48
    Marker Score: 457
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.48
    Marker Score: 3,141
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.48
    Marker Score: 1,221
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.48
    Marker Score: 207
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.48
    Marker Score: 160
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.46
    Marker Score: 415
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.46
    Marker Score: 130
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.46
    Marker Score: 104
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.46
    Marker Score: 463
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.45
    Marker Score: 476
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.45
    Marker Score: 737
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.45
    Marker Score: 15,212
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 186
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.44
    Marker Score: 5,006
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.44
    Marker Score: 116
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.43
    Marker Score: 668
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.43
    Marker Score: 462
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.43
    Marker Score: 135
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.43
    Marker Score: 370
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.43
    Marker Score: 286
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.43
    Marker Score: 802
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.42
    Marker Score: 267
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.42
    Marker Score: 99
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.42
    Marker Score: 843
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.42
    Marker Score: 231
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.42
    Marker Score: 223
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.42
    Marker Score: 601
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 180
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.41
    Marker Score: 237
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.41
    Marker Score: 251
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.41
    Marker Score: 857
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.41
    Marker Score: 659
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.41
    Marker Score: 21,638
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.41
    Marker Score: 90
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.41
    Marker Score: 169
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.41
    Marker Score: 92
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.41
    Marker Score: 272
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.4
    Marker Score: 81
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.4
    Marker Score: 184
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4
    Marker Score: 166
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4
    Marker Score: 973
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.4
    Marker Score: 236
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.4
    Marker Score: 243
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.4
    Marker Score: 165
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.39
    Marker Score: 211
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.39
    Marker Score: 473

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFIT5 is a member of the interferon-induced protein family, characterized by the presence of tetratricopeptide repeats. These repeats are essential for its interaction with other proteins, influencing its localization, stability, and function. IFIT5 is primarily induced by interferons, particularly interferon-alpha and interferon-beta, which are key players in the antiviral response. Its expression is tightly regulated, with significant fluctuations in response to viral infections, cellular stress, and tissue damage. **Pathways and Functions:** IFIT5 is involved in various signaling pathways that regulate immune responses, including: 1. **Interferon signaling:** IFIT5 is a key component of the interferon-induced antiviral response, acting as a negative regulator of viral genome replication. 2. **Cytokine signaling:** IFIT5 modulates cytokine signaling, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **Immune cell regulation:** IFIT5 affects the function and differentiation of immune cells, including T cells, B cells, and dendritic cells. 4. **Apoptosis regulation:** IFIT5 has been implicated in the regulation of apoptosis, influencing the survival and death of cells in response to stress and damage. **Clinical Significance:** IFIT5 has been implicated in various diseases, including: 1. **Cancer:** IFIT5 has been identified as a tumor suppressor gene, with its expression reduced in several types of cancer, including lung, breast, and colon cancer. 2. **Autoimmune disorders:** IFIT5 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where its dysregulation contributes to immune dysbalance. 3. **Neurological conditions:** IFIT5 has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where its expression is altered in response to cellular stress and damage. In conclusion, IFIT5 is a multifaceted gene that plays a crucial role in regulating immune responses, cellular stress, and tissue damage. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying its function and its potential as a therapeutic target.

Genular Protein ID: 2441577733

Symbol: IFIT5_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 5

UniProtKB Accession Codes:

Q13325 B2R5X9 B4DDV1 Q5T7I9 Q6IAX3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9398535

Title: A novel interferon-inducible gene expressed during myeloid differentiation.

PubMed ID: 9398535

DOI: 10.1006/bcmd.1997.0151

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 25092312

Title: Broad and adaptable RNA structure recognition by the human interferon-induced tetratricopeptide repeat protein IFIT5.

PubMed ID: 25092312

DOI: 10.1073/pnas.1412842111

PubMed ID: 26334375

Title: IFIT5 positively regulates NF-kappaB signaling through synergizing the recruitment of IkappaB kinase (IKK) to TGF-beta-activated kinase 1 (TAK1).

PubMed ID: 26334375

DOI: 10.1016/j.cellsig.2015.08.018

PubMed ID: 23774268

Title: Crystal structure and nucleotide selectivity of human IFIT5/ISG58.

PubMed ID: 23774268

DOI: 10.1038/cr.2013.80

PubMed ID: 23317505

Title: tRNA binding, structure, and localization of the human interferon-induced protein IFIT5.

PubMed ID: 23317505

DOI: 10.1016/j.molcel.2012.12.015

PubMed ID: 23334420

Title: Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.

PubMed ID: 23334420

DOI: 10.1038/nature11783

Sequence Information:

  • Length: 482
  • Mass: 55847
  • Checksum: 8045BC100384BE05
  • Sequence:
    • MSEIRKDTLK AILLELECHF TWNLLKEDID LFEVEDTIGQ QLEFLTTKSR LALYNLLAYV 
KHLKGQNKDA LECLEQAEEI IQQEHSDKEE VRSLVTWGNY AWVYYHMDQL EEAQKYTGKI 
GNVCKKLSSP SNYKLECPET DCEKGWALLK FGGKYYQKAK AAFEKALEVE PDNPEFNIGY 
AITVYRLDDS DREGSVKSFS LGPLRKAVTL NPDNSYIKVF LALKLQDVHA EAEGEKYIEE 
ILDQISSQPY VLRYAAKFYR RKNSWNKALE LLKKALEVTP TSSFLHHQMG LCYRAQMIQI 
KKATHNRPKG KDKLKVDELI SSAIFHFKAA MERDSMFAFA YTDLANMYAE GGQYSNAEDI 
FRKALRLENI TDDHKHQIHY HYGRFQEFHR KSENTAIHHY LEALKVKDRS PLRTKLTSAL 
KKLSTKRLCH NALDVQSLSA LGFVYKLEGE KRQAAEYYEK AQKIDPENAE FLTALCELRL 
SI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.