Details for: EML2

Gene ID: 24139

Symbol: EML2

Ensembl ID: ENSG00000125746

Description: EMAP like 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.84
    Marker Score: 67,812
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.82
    Marker Score: 18,771
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.67
    Marker Score: 63,285
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.66
    Marker Score: 12,758
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.63
    Marker Score: 6,296
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.6
    Marker Score: 23,945
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.57
    Marker Score: 6,520
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.54
    Marker Score: 14,511
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.53
    Marker Score: 641
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5
    Marker Score: 92,310
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.49
    Marker Score: 1,641
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.46
    Marker Score: 29,135
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,904
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.44
    Marker Score: 2,223
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.38
    Marker Score: 13,099
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.34
    Marker Score: 11,481
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3
    Marker Score: 5,126
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.28
    Marker Score: 5,195
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.25
    Marker Score: 341
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.24
    Marker Score: 2,962
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.24
    Marker Score: 1,822
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.23
    Marker Score: 2,039
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.23
    Marker Score: 366
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.2
    Marker Score: 3,437
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.16
    Marker Score: 1,217
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.14
    Marker Score: 9,833
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.07
    Marker Score: 9,334
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.04
    Marker Score: 958
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.01
    Marker Score: 319
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,707
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,931
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,394
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.97
    Marker Score: 1,724
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14,974
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.95
    Marker Score: 7,088
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,401
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 434
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.92
    Marker Score: 689
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,704
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.9
    Marker Score: 719
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.87
    Marker Score: 1,459
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.87
    Marker Score: 1,831
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5,234
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4,858
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 306
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.82
    Marker Score: 5,269
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.82
    Marker Score: 686
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.82
    Marker Score: 1,023
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.81
    Marker Score: 920
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.8
    Marker Score: 835
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.8
    Marker Score: 380
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.79
    Marker Score: 1,020
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.78
    Marker Score: 158
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,265
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 582
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.76
    Marker Score: 375
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.76
    Marker Score: 1,441
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.76
    Marker Score: 399
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.75
    Marker Score: 235
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.73
    Marker Score: 256
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.73
    Marker Score: 1,490
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.73
    Marker Score: 883
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,058
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.73
    Marker Score: 2,078
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.71
    Marker Score: 493
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.7
    Marker Score: 5,465
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.7
    Marker Score: 2,402
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.7
    Marker Score: 572
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.69
    Marker Score: 655
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.69
    Marker Score: 543
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.68
    Marker Score: 787
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.68
    Marker Score: 278
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.68
    Marker Score: 4,321
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 612
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.67
    Marker Score: 248
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.66
    Marker Score: 674
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.66
    Marker Score: 1,619
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.66
    Marker Score: 878
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.66
    Marker Score: 2,071
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 436
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.66
    Marker Score: 1,445
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.64
    Marker Score: 749
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.64
    Marker Score: 1,014
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 383
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.63
    Marker Score: 1,498
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.63
    Marker Score: 295
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.63
    Marker Score: 13,404
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.63
    Marker Score: 1,207
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.63
    Marker Score: 887
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.62
    Marker Score: 620
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 395
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.62
    Marker Score: 1,398
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.62
    Marker Score: 664
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.61
    Marker Score: 257
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.61
    Marker Score: 867
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.61
    Marker Score: 7,077

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EML2 is a member of the echinoderm microtubule-associated protein (EMAP) family, which is characterized by their ability to interact with microtubules and regulate their dynamics. The EML2 protein is specifically involved in the negative regulation of microtubule polymerization and the regulation of microtubule nucleation. This suggests that EML2 plays a critical role in maintaining the balance between microtubule growth and depolymerization, which is essential for maintaining cellular homeostasis and proper neuronal function. **Pathways and Functions:** The EML2 protein is involved in several key pathways, including: 1. **Microtubule organization and cytoskeleton dynamics:** EML2 regulates microtubule polymerization and nucleation, which is essential for maintaining the structural integrity of the cytoskeleton and ensuring proper neuronal function. 2. **Sensory perception of sound:** EML2 has been implicated in the regulation of microtubule dynamics in auditory neurons, suggesting a role in the sensory processing of sound. 3. **Visual perception:** EML2 is also expressed in retinal ganglion cells, where it may play a role in the regulation of microtubule dynamics and the processing of visual information. 4. **Protein binding and self-association:** EML2 interacts with other proteins to regulate microtubule dynamics, including tubulin and microtubule-associated proteins. **Clinical Significance:** The EML2 gene's involvement in microtubule dynamics and neuronal function has significant implications for understanding neurological disorders, particularly those related to neurodegeneration. Mutations in the EML2 gene have been implicated in several neurodegenerative diseases, including: 1. **Neurodegenerative disorders:** EML2's role in regulating microtubule dynamics suggests that mutations in the gene may contribute to the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Neuronal development and function:** EML2's expression in various neuronal populations suggests that the gene plays a critical role in the development and function of the nervous system, particularly in the regulation of microtubule dynamics and cytoskeleton organization. 3. **Therapeutic potential:** Understanding the role of EML2 in microtubule dynamics and neuronal function may provide new therapeutic targets for the treatment of neurodegenerative disorders and other neurological diseases. In conclusion, the EML2 gene is a critical component of the microtubule dynamics machinery, and its dysregulation has significant implications for understanding neurological function and disease. Further research is needed to fully elucidate the role of EML2 in microtubule dynamics and its potential therapeutic applications.

Genular Protein ID: 2577245995

Symbol: EMAL2_HUMAN

Name: Echinoderm microtubule-associated protein-like 2

UniProtKB Accession Codes:

O95834 B7Z3I2 B7Z3Q9 K7ERL7 Q59EN8 Q8N5A2 Q9UG50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10521658

Title: Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).

PubMed ID: 10521658

DOI: 10.1016/s0378-1119(99)00335-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11694528

Title: The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus.

PubMed ID: 11694528

DOI: 10.1074/jbc.m106628200

PubMed ID: 24706829

Title: Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical beta-propeller domain.

PubMed ID: 24706829

DOI: 10.1073/pnas.1322892111

PubMed ID: 25740311

Title: Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

PubMed ID: 25740311

DOI: 10.1042/bj20150039

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 649
  • Mass: 70679
  • Checksum: F356D3D974D208C9
  • Sequence:
    • MSSFGAGKTK EVIFSVEDGS VKMFLRGRPV PMMIPDELAP TYSLDTRSEL PSCRLKLEWV 
YGYRGRDCRA NLYLLPTGEI VYFVASVAVL YSVEEQRQRH YLGHNDDIKC LAIHPDMVTI 
ATGQVAGTTK EGKPLPPHVR IWDSVSLSTL HVLGLGVFDR AVCCVGFSKS NGGNLLCAVD 
ESNDHMLSVW DWAKETKVVD VKCSNEAVLV ATFHPTDPTV LITCGKSHIY FWTLEGGSLS 
KRQGLFEKHE KPKYVLCVTF LEGGDVVTGD SGGNLYVWGK GGNRITQAVL GAHDGGVFGL 
CALRDGTLVS GGGRDRRVVL WGSDYSKLQE VEVPEDFGPV RTVAEGHGDT LYVGTTRNSI 
LQGSVHTGFS LLVQGHVEEL WGLATHPSRA QFVTCGQDKL VHLWSSDSHQ PLWSRIIEDP 
ARSAGFHPSG SVLAVGTVTG RWLLLDTETH DLVAIHTDGN EQISVVSFSP DGAYLAVGSH 
DNLVYVYTVD QGGRKVSRLG KCSGHSSFIT HLDWAQDSSC FVTNSGDYEI LYWDPATCKQ 
ITSADAVRNM EWATATCVLG FGVFGIWSEG ADGTDINAVA RSHDGKLLAS ADDFGKVHLF 
SYPCCQPRAL SHKYGGHSSH VTNVAFLWDD SMALTTGGKD TSVLQWRVV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.