Details for: FTSJ1

Gene ID: 24140

Symbol: FTSJ1

Ensembl ID: ENSG00000068438

Description: FtsJ RNA 2'-O-methyltransferase 1

Associated with

Other Information

Genular Protein ID: 3156261230

Symbol: TRM7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15162322

Title: Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation.

PubMed ID: 15162322

DOI: 10.1086/422507

PubMed ID: 15342698

Title: A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9).

PubMed ID: 15342698

DOI: 10.1136/jmg.2004.019000

PubMed ID: 18081026

Title: A loss-of-function mutation in the FTSJ1 gene causes nonsyndromic X-linked mental retardation in a Japanese family.

PubMed ID: 18081026

DOI: 10.1002/ajmg.b.30638

PubMed ID: 18401546

Title: Positive association of the FTSJ1 gene polymorphisms with nonsyndromic X-linked mental retardation in young Chinese male subjects.

PubMed ID: 18401546

DOI: 10.1007/s10038-008-0287-x

PubMed ID: 19012053

Title: Genetic variations in FTSJ1 influence cognitive ability in young males in the Chinese Han population.

PubMed ID: 19012053

DOI: 10.1080/01677060802337299

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25404562

Title: Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes.

PubMed ID: 25404562

DOI: 10.1261/rna.047639.114

PubMed ID: 32393790

Title: FTSJ1 regulates tRNA 2'-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression.

PubMed ID: 32393790

DOI: 10.1038/s41419-020-2525-x

PubMed ID: 32488007

Title:

PubMed ID: 32488007

DOI: 10.1038/s41419-020-2623-9

PubMed ID: 32558197

Title: Intellectual disability-associated gene ftsj1 is responsible for 2'-O-methylation of specific tRNAs.

PubMed ID: 32558197

DOI: 10.15252/embr.202050095

PubMed ID: 32198346

Title: 2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations.

PubMed ID: 32198346

DOI: 10.1038/s41467-020-15140-z

PubMed ID: 33771871

Title: Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability.

PubMed ID: 33771871

DOI: 10.1126/sciadv.abf3072

PubMed ID: 26310293

Title: Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1.

PubMed ID: 26310293

DOI: 10.1002/humu.22897

PubMed ID: 36720500

Title: The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance.

PubMed ID: 36720500

DOI: 10.26508/lsa.202201877

Sequence Information:

  • Length: 329
  • Mass: 36079
  • Checksum: 9A85D63A4FA80615
  • Sequence:
  • MGRTSKDKRD VYYRLAKENG WRARSAFKLL QLDKEFQLFQ GVTRAVDLCA APGSWSQVLS 
    QKIGGQGSGH VVAVDLQAMA PLPGVVQIQG DITQLSTAKE IIQHFKGCPA DLVVCDGAPD 
    VTGLHDVDEY MQAQLLLAAL NIATHVLKPG GCFVAKIFRG RDVTLLYSQL QVFFSSVLCA 
    KPRSSRNSSI EAFAVCQGYD PPEGFIPDLS KPLLDHSYDP DFNQLDGPTR IIVPFVTCGD 
    LSSYDSDRSY PLDLEGGSEY KYTPPTQPPI SPPYQEACTL KRKGQLAKEI RPQDCPISRV 
    DTFPQPLAAP QCHTLLAPEM EDNEMSCSP

Genular Protein ID: 1313796041

Symbol: B7Z4K4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 192
  • Mass: 21231
  • Checksum: B1691B8E11B3CFD6
  • Sequence:
  • MALNIATHVL KPGGCFVAKI FRGRDVTLLY SQLQVFFSSV LCAKPRSSRN SSIEAFAVCQ 
    GYDPPEGFIP DLSKPLLDHS YDPDFNQLDG PTRIIVPFVT CGDLSSYDSD RSYPLDLEGG 
    SEYKYTPPTQ PPISPPYQEA CTLKRKGQLA KEIRPQDCPI SRVDTFPQPL AAPQCHTLLA 
    PEMEDNEMSC SP

Genular Protein ID: 3619318356

Symbol: B3KN91_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 327
  • Mass: 35895
  • Checksum: 97417C32D8515DF7
  • Sequence:
  • MGRTSKDKRD VYYRLAKENG WRARSAFKLL QLDKEFQLFQ GVTRAVDLCA APGSWSQVLS 
    RKIGGQGSGH VVAVDLQAMA PLPGVVQIQG DITQLSTAKE IIQHFKGCPA DLVVCDGAPD 
    VTGLHDVDEY MQAQLLLAAL NIATHVLKPG GCFVAKIFRG RDVTLLYSQL QVFFSSVLCA 
    KPRSSRNSSI EAFAVCQGYD PPEGFIPDLS KPLLDHSYDF NQLDGPTRII VPFVTCGDLS 
    SYDSDRSYPL DLEGGSEYKY TPPTQPPISP PYQEACTLKR KGQLAKEIRP QDCPISRVDT 
    FPQPLAAPQC HTLLAPEMED NEMSCSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.